The Assembly of Nano-Materials Using Bio-Scaffolding

Abstract

Bio-assembly strategies may allow formation of high-density nano-electronic architectures possessing unique electronic properties. These bio-nanomaterial hybrids should exhibit bio- compatibility and bio-viability. Therefore, contingencies of maintaining tertiary structure in the presence of nanometer-sized particles are a potential fatal flaw in bio-scaffolded assemblies. In this manuscript we investigate the assembly of bio-scaffolded nanomaterial constructs, specifically polypeptides, while probing the issue of bio-compatibility and viability by TEM imaging.

Enzymatic Manipulation of DNA−Nanomaterial Constructs

“…Methyl transfer to the extra-helical adenine requires the cofactor S-adenosylmethionine. M. Hha I on the other hand, flips out its target base, 5‘-C of GCGC, but does not bend the target DNA . Using highly selective bacterial proteins that induce sequence-specific conformational perturbations within DNA, we observe the absolute maintenance of bifunction for biomaterials composed of duplex DNA appended with 1.4-nm Au particles.…”