The Assessment of Anxiety States by Rating

Hamilton, Max

doi:10.1111/j.2044-8341.1959.tb00467.x

Cited by 9,882 publications

(4,854 citation statements)

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“…Additional post hoc analyses included the assessment of functional impairment in patients with severe MDD (MADRS total score ≥30 at baseline), patients with significant functional impairment (SDS total score ≥18 at baseline), both severe MDD and significant functional impairment (MADRS total score ≥30 and SDS total score ≥18 at baseline), and high levels of anxious symptoms (Hamilton Anxiety Rating Scale [HAM‐A; Hamilton, 1959] total score ≥20 at baseline). An exploratory analysis was conducted to evaluate the achievement of double remission in patients working at study endpoint (based on the FAS using observed cases).…”

Section: Methodsmentioning

confidence: 99%

The effect of vortioxetine on overall patient functioning in patients with major depressive disorder

et al. 2017

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BackgroundThe objectives of this meta‐analysis of data from randomized, placebo‐controlled studies were to assess the effect of vortioxetine on overall functioning (primary) and functional remission (secondary) using the Sheehan Disability Scale (SDS) in adults with major depressive disorder (MDD).MethodsData from nine short‐term (6/8 weeks) pivotal studies that included patient functioning assessments were included in this random‐effects meta‐analysis, which used aggregated study‐level data for all therapeutic vortioxetine doses and a mixed‐effect model for repeated measures using the full analysis set.ResultsA total of 4,216 patients received ≥1 dose of study treatment (1,522 placebo, 2,694 vortioxetine 5–20 mg/day). At study end, the meta‐analysis showed improvement for vortioxetine versus placebo (n = 911) in SDS total score (vortioxetine 5 mg, n = 564, change from baseline versus placebo [Δ] −0.24, p = NS; 10 mg, n = 445, Δ −1.68, p ≤ .001; 15 mg, n = 204, Δ −0.91, p = NS; 20 mg, n = 340, Δ −1.94, p ≤ .01). Functional remission (SDS total score ≤6) was observed with vortioxetine 10 mg (n = 170/573; odds ratio [OR] relative to placebo 1.7, p < .001) and 20 mg (n = 144/447; OR 1.6, p < .05), but not 5 mg (n = 207/757; OR 1.1, p = NS) or 15 mg (n = 92/295; OR 1.3, p = NS).ConclusionVortioxetine 5–20 mg for 6/8 weeks improved overall patient functioning in patients with MDD. Relative to placebo, vortioxetine 10 and 20 mg demonstrated significant improvement in SDS total score and functional remission.

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Section: Methodsmentioning

confidence: 99%

The effect of vortioxetine on overall patient functioning in patients with major depressive disorder

et al. 2017

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“…Importantly, both MJ and control teens demonstrated similar levels of estimated premorbid IQ, as assessed by the Wechsler Abbreviated Scale of Intelligence Vocabulary subtest (Wechsler, 1999) and socioeconomic status (Hollingshead, 1965). MJ teens showed higher levels of depressive symptoms on the Hamilton Depression Rating Scale (Hamilton, 1960) (P < 0.05) and the Beck Depression Inventory (Beck, 1978) (P = 0.07), as well as higher levels of anxiety on the Hamilton Anxiety Rating Scale (Hamilton, 1959) (P < 0.05). MJ teens had more lifetime and recent experience with alcohol than controls (P < 0.05), yet five MJ teens reported no alcohol use in the month before the abstinence period.…”

Section: Participantsmentioning

confidence: 98%

“…Hamilton Depression Rating Scale (Hamilton, 1960), the Beck Depression Inventory (Beck, 1978), the Hamilton Anxiety Rating Scale (Hamilton, 1959), and the State scale of the Spielberger State-Trait Anxiety Inventory (Spielberger et al, 1970) assessed mood at the time of scanning. The NEO Five-Factor Inventory (NEO-FFI) (Costa and McCrae, 1992) ascertained the following characteristics according to the five-factor model of personality: degree of neuroticism, extraversion, openness, agreeableness, and conscientiousness.…”

Section: State and Behavioral Measures-thementioning

confidence: 99%

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Schweinsburg¹,

Nagel²,

Schweinsburg³

et al. 2008

Psychiatry Research: Neuroimaging

172

168

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Marijuana is the most widely used illicit substance among teenagers, yet little is known about the possible neural influence of heavy marijuana use during adolescence. We previously demonstrated an altered functional magnetic resonance imaging (fMRI) activity related to spatial working memory (SWM) among adolescents who were heavy users of after an average of 8 days of abstinence, but the persisting neural effects remain unclear. To characterize the potentially persisting neurocognitive effects of heavy marijuana use in adolescence, we examined fMRI response during SWM among abstinent marijuana-using teens. Participants were 15 MJ teens and 17 demographically similar nonusing controls, ages 16-18. Teens underwent biweekly urine toxicology screens to ensure abstinence for 28 days before fMRI acquisition. Groups performed similarly on the SWM task, but MJ teens demonstrated lower activity in right dorsolateral prefrontal and occipital cortices, yet significantly more activation in right posterior parietal cortex. MJ teens showed abnormalities in brain response during a SWM task compared with controls, even after 1 month of abstinence. The activation pattern among MJ teens may reflect different patterns of utilization of spatial rehearsal and attention strategies, and could indicate altered neurodevelopment or persisting abnormalities associated with heavy marijuana use in adolescence.

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“…In addition to the clinical interview, the Hamilton Anxiety Rating Scale (HRSA; Hamilton, 1959) was used to assess general anxiety symptomology, the Penn State Worry Questionnaire (PSWQ) was used to measure the intensity of pathological worry (Meyer et al, 1990), and the Generalized Anxiety Disorder Severity Scale (GADSS; Shear et al, 2006) was used to measure the severity of GAD-specific symptoms.…”

Section: Clinical Measuresmentioning

confidence: 99%

Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder

Mantella

Butters

Amico

et al. 2008

Psychoneuroendocrinology

191

151

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SummaryAge-associated alterations in hypothalamic-pituitary-adrenal (HPA) axis functioning may make individuals more susceptible to HPA dysregulation in the context of mood and anxiety disorders. Little to no research has been done to examine HPA axis function in generalized anxiety disorder (GAD), particularly in late-life GAD, the most prevalent anxiety disorder in the elderly. The study sample consisted of 71 GAD subjects and 40 nonanxious comparison subjects over 60 years of age. We examined the hypotheses that elderly individuals with GAD will have elevated salivary cortisol levels compared to nonanxious subjects, and that elevated cortisol levels in GAD will be associated with measures of symptom severity. We report that late-life GAD is characterized by elevated basal salivary cortisol levels, with higher peak cortisol levels and larger areas under the curve, compared to nonanxious subjects. Additionally, severity of GAD as measured by the GAD Severity Scale and the Penn State Worry Questionnaire are positively correlated with cortisol levels. These data demonstrate HPA axis dysfunction in late-life GAD and suggest the need for additional research on the influence of aging on HPA axis function in mood and anxiety disorders.

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The Assessment of Anxiety States by Rating

Cited by 9,882 publications

References 0 publications

The effect of vortioxetine on overall patient functioning in patients with major depressive disorder

The effect of vortioxetine on overall patient functioning in patients with major depressive disorder

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder

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