The assessment of lactate in experimental acute myocardial infarction

Timercan, V.; Timercan, Tatiana

doi:10.31688/abmu.2021.56.4.07

Cited by 1 publication

(2 citation statements)

References 22 publications

(58 reference statements)

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“…The enzyme reduces the need for the new synthesis of GSH from amino acids. GR function is in constant correlation with GPO and GST, enzymes that oxidize GSH in peroxide reduction processes [29,30].…”

Section: Discussionmentioning

confidence: 99%

“…Glutathione peroxidase in mitochondria and peroxisomes works in tandem with catalase, and in the cytoplasm with SOD, which ensures, together with non-enzymatic antioxidants, the protection of subcellular structures and the modulation of the oxygen activation process by deregulating the formation of the hydroxyl radical (OH•). Glutathione-S-transferase catalyzes the conjugation of GSH with electrophilic organic compounds, an important detoxification reaction of exogenous products and the neutralization of endogenous substances within the physiological processes of metabolic waste elimination [29,30].…”

Section: Discussionmentioning

confidence: 99%

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The impact of imuheptin and imupurin on cytokine profile and antioxidant status in rat model of inflammation

Gutu,

Bacinschi,

Gudumac

2023

MJHS

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Introduction. Insects, throughout evolution, have developed a huge arsenal of active compounds, which they use to defend themselves against enemies and diseases, at the same time in recent years insects have shown great interest as a source of food rich in biologically active substances. Research in recent decades has shown that insects produce a variety of proteins and peptides with antibacterial, antifungal, antiviral, immunomodulatory, anti-inflammatory, antioxidant, antitumor, hepatoprotective, antithrombotic, antihypertensive and detoxifying activity during or after contact with the microbial agent or unfavourable factor. Material and methods. The anti-inflammatory effect of imuheptin and imupurin was investigated in a rat model of subacute inflammation induced by subcutaneous implantation of felt discs. The intensity of the exudative and proliferative phase of inflammation, cytokine profile (TNFalpha, IL-6, IL-10), ceruloplasmin and antioxidant enzymes (superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione-S-transferase) in the serum of rats were evaluated. Results. Imuheptin and imupurin reduced the level of pro-inflammatory cytokines (TNF-alpha, IL-6) and increased that of the anti-inflammatory cytokine (IL-10), as well as ceruloplasmin, glutathione reductase and glutathione peroxidase in subacute inflammation. Additionally, imupurin significantly increased the level of catalase and imuheptin that of glutathioneS-transferase. Conclusions. Imuheptin and imupurin determined a moderate effect of inhibiting the exudative and proliferative processes, compared to the reference preparation - dexamethasone, but with a favourable effect on the cytokine profile, decreasing the level of pro-inflammatory cytokines (TNF-alpha, IL-6) and increasing the level the anti-inflammatory one (IL-10), as well as the modulation of antioxidant enzyme activity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%