The assessment of optical coherence tomographic parameters in subjects with a positive family history of glaucoma

Kartı, Ömer; Yüksel, Bora; Uzunel, Umut Duygu; Karahan, Eyyüp; Zengin, Mehmet Özgür; Küsbeci, Tuncay

doi:10.1111/cxo.12523

Cited by 9 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparable diagnostic capability of GC-IPL to that of RNFL thickness measurements has been reported for PPG. [ 16 17 ] Kim et al . reported that the inner directional angle of RNFL defects affected the diagnostic sensitivity of macular GC-IPL parameters.…”

Section: Discussionmentioning

confidence: 99%

“…[ 18 ] Recently it has been found that significantly lower RNFL and GCC measurements were present in normal looking discs of individuals with a history of POAG in their first-degree relatives, compared to individuals without a similar history. [ 16 ] Lee and associates, found that inferotemporal thickness on GC-IPL had the best AUC in a study comprising wide field RNFL maps in eyes with PPG. [ 19 ] Inuzuka studied 77 eyes of PPG and reported that GC-IPL thicknesses in the inferior and inferotemporal sectors might serve as useful parameters to track the progression of glaucomatous changes in eyes with PPG.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of ganglion cell-inner plexiform layer thickness in the diagnosis of preperimetric glaucoma and comparison to retinal nerve fiber layer

Deshpande

Gupta

Bawankule

et al. 2021

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: The aim of this study was to evaluate the diagnostic ability of optic nerve head (ONH), RNFL, and GC-IPL parameters in differentiating eyes with PPG from normals. Methods: This was a retrospective, cross-sectional, observational study. We studied 73 eyes of 41 patients and compared them to 65 eyes of 34 normal persons. Each patient underwent detailed ocular examination, standard automated perimetry, GC-IPL, ONH, and RNFL analysis. PPG was defined as eyes with normal visual field results and one or more localized RNFL defects that were associated with a glaucomatous disc appearance (e.g., notching or thinning of neuroretinal rim) and IOP more than 21 mm Hg. Diagnostic abilities of GC-IPL, ONH, and RNFL parameters were computed using area under receiver-operating curve (AUROC), sensitivity and specificity, and likelihood ratios (LRs). Results: All GC-IPL parameters differed significantly from normal. The ONH, RNFL, and GC-IPL parameters with best area under curves (AUCs) to differentiate PPG were vertical cup to disc ratio (0.76), inferior quadrant RNFL thickness (0.79), and inferotemporal quadrant GC-IPL thickness (0.73), respectively. Similarly, best LRs were found for clock hour 5, 6, and 12 thicknesses among RNFL; inferior sector and inferotemporal sector thicknesses among GC-IPL parameters. Conclusion: Diagnostic abilities of GC-IPL parameters were comparable to RNFL parameters in differentiating PPG patients from normals. The likelihood of ruling in a disease was greater with GC-IPL parameters.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of ganglion cell-inner plexiform layer thickness in the diagnosis of preperimetric glaucoma and comparison to retinal nerve fiber layer

Deshpande

Gupta

Bawankule

et al. 2021

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…The few studies that have evaluated GCA for preperimetric glaucoma diagnosis have reported comparable diagnostic capability to that of RNFL thickness measurements. [ 27 28 ] Kim et al . [ 26 ] reported that the inner directional angle of RNFL defects affected the diagnostic sensitivity of macular ganglion cell-inner plexiform layer parameters in their study.…”

Section: Discussionmentioning

confidence: 99%

“…Karti et al . [ 28 ] reported significantly lower RNFL and ganglion cell complex measurements in normal looking discs of individuals who had a history of POAG in their first-degree relatives, compared to individuals without a family history. Jung et al .,[ 29 ] in a structure-function relationship study, reported that preperimetric glaucoma patients with structural loss in the macula also had functional loss revealed by 10-2 short-wavelength automated perimetry, even though 24-2 visual fields were normal.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of macular ganglion cell analysis compared to retinal nerve fiber layer thickness for preperimetric glaucoma diagnosis

Kaushik

Kataria

Jain

et al. 2018

Indian J Ophthalmol

View full text Add to dashboard Cite

Purpose:To compare the diagnostic ability of the ganglion cell analysis (GCA) and retinal nerve fiber layer (RNFL) protocol on optical coherence tomography (OCT), to diagnose preperimetric glaucoma.Methods:A prospective, cross-sectional study of 275 adult patients including 47 early glaucoma (mean deviation better than -6.0 D), 150 glaucoma suspects (106 with suspicious discs and 44 ocular hypertensive (OHT), and 78 normal controls was done. Eligible participants were scanned with the spectral domain Cirrus™ OCT (Carl Zeiss Meditec, Dublin, CA). Average peripapillary RNFL thickness and GCA measurements were obtained. Area under receiver operating characteristic (AROC) curves were used to evaluate discriminant value of both protocols to diagnose likely preperimetric glaucoma among glaucoma suspects.Results:Average RNFL and GCA were significantly thinner in glaucoma patients compared to glaucoma suspects and normal controls (P < 0.001). The RNFL was 92.26 ± 8.8 μ in normal controls, 87.9 ± 12.12 μ in glaucoma suspects and significantly thinner in POAG (70.29 ± 10.18 μ; P < 0.001). The GCA was 81.94 ± 6.17 μ in normal controls, 77.69 ± 9.03 μ in glaucoma suspects, and significantly thinner in POAG (69.36 ± 11.06 μ; P < 0.001). AROCs for discriminating glaucoma suspects from normal were modest, with no difference in AROC of average RNFL or GCA measurements (DeLong; P = 0.93). Average RNFL thickness had significantly greater AROC values than average GCA for discriminating glaucoma suspects (both suspicious discs and OHT) from glaucoma (P = 0.03 and 0.05, respectively. AROC for diagnosing glaucoma was significantly better (P = 0.02) for RNFL (0.88 ± 0.03) than GCA (0.77 ± 0.04).Conclusion:In the present time, GCA measurements, as provided by the SD-OCT, do not appear to outperform RNFL measurements in the diagnosis of preperimetric glaucoma.

show abstract

“…There was no significant difference in nasal quadrant RNFL thickness between POAG suspect and controls (72.93±16.69 μm versus 77.08±9.28 μm, p=0.096). Karti et al, reported significantly lower RNFL and ganglion cell complex measurements in normal looking discs of individuals who had a history of POAG in their first-degree relatives, compared to individuals without a family history 32.…”

mentioning

confidence: 99%

Evaluation of retinal nerve fibre layer, optic nerve head, and macular ganglion cell analysis measurements for early glaucoma detection using spectral domain optical coherence tomography

Bhardwaj¹,

Sharma²,

Gaur³

et al. 2020

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Glaucoma is the leading cause of irreversible blindness worldwide. It is very important to diagnose glaucoma in early stages so that timely management can be done. Spectral domain optical coherence tomography (SD-OCT), is a newer device which helps to diagnose glaucoma early. The aim of our study was to evaluate the RNFL, ONH, and mGCA (GCL+IPL) measurements for early glaucoma detection using spectral domain optical coherence tomography (SD-OCT).Methods: Total 30, POAG (primary open angle glaucoma) suspects were compared with 30 normal controls. The Cirrus HD-OCT optic disc cube 200 × 200 protocol was used to measure ONH, RNFL and macular parameters.Results: The average cpRNFL thickness of all quadrants was significantly lower in POAG suspects, (84.13±7.42 μm versus 103.85±8.95 μm, p<0.001). The superior GCL+IPL thickness of POAG suspects and controls was 75.75±2.60 μm and 80.05±1.74 μm, respectively, (p<0.001). The inferior GCL+IPL thickness of POAG suspects and controls was 75.98±2.59 μm and 80.00±1.79 μm, respectively, (p<0.001).Conclusions: The SD-OCT is an important device to diagnose POAG suspects, early. The GCA measurements and average RNFL (especially superior and inferior) measurements, both are equally good to discriminate between glaucoma suspects and normal controls.

show abstract

The assessment of optical coherence tomographic parameters in subjects with a positive family history of glaucoma

Cited by 9 publications

References 23 publications

Evaluation of ganglion cell-inner plexiform layer thickness in the diagnosis of preperimetric glaucoma and comparison to retinal nerve fiber layer

Evaluation of ganglion cell-inner plexiform layer thickness in the diagnosis of preperimetric glaucoma and comparison to retinal nerve fiber layer

Evaluation of macular ganglion cell analysis compared to retinal nerve fiber layer thickness for preperimetric glaucoma diagnosis

Evaluation of retinal nerve fibre layer, optic nerve head, and macular ganglion cell analysis measurements for early glaucoma detection using spectral domain optical coherence tomography

Contact Info

Product

Resources

About