Objective. To develop, implement, and review a competence-assessment program to identify students at risk of underperforming at advanced pharmacy practice experience (APPE) sites and to facilitate remediation before they assume responsibility for patient care. Design. As part of the standardized client program, pharmacy students were examined in realistic live client-encounter simulations. Authentic scenarios were developed, and actors were recruited and trained to portray clients so students could be examined solving multiple pharmacy problems. Evaluations of students were conducted in the broad areas of knowledge and live performance. Assessment. Measurements included student-experience survey instruments used to evaluate case realism and challenge; videos used to determine the fidelity of standardized clients, and clerkship performance predictions used to identify students who required individual attention and improvement prior to clerkship courses. Conclusions. The assessment program showed promise as a means of discriminating between students who are prepared for APPEs and those at risk for underperforming.