The Assessment of Serum Endocan Levels in Children With Juvenile Idiopathic Arthritis

Yılmaz, Yasin; Durmuş, Rana Berru; Saracoglu, Basak; Şahin, Sezgin; Adroviç, Amra; Barut, Kenan; Yıldız, Sevda; Kasapçopur, Özgür; Eker, Rukiye

doi:10.5606/archrheumatol.2018.6528

Cited by 8 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, its levels were positively correlated with disease activity (DAS-28), HAQ-DI and modified Larsen score ( Table 3). This result was partially in line with others who reported the same results in juvenile RA but with lower levels in active disease than those in remission which could be secondary to drug effect or more healthy endothelial in young age and also mostly the absence of vascular disorders, mainly atherosclerosis [22]. It is suggested that serum ESM-1 levels rise in synovial tissue of rheumatoid patients and arouse mainly by adiponectin.…”

Section: Das Esm1supporting

confidence: 90%

“…Furthermore, ESM-1 can induce angiogenesis, which can elucidate pannus formation [23] and was detected in affected inflamed joints and its level was correlated with inflammation magnitude [23]. We reported a positive correlation between ESM-1 and ESR and CRP indicated that ESM-1 is linked to the inflammatory state in RA but another study failed to report such correlation [22]. Others reported that ESM-1 was elevated and correlated with ESR and CRP in Behcet's disease [14], SLE [24], SS [25] & IBD [13].…”

Section: Das Esm1mentioning

confidence: 69%

See 1 more Smart Citation

Serum Level of Endothelial Cell-Specific Molecule -1 (ESM -1) as a New Potential Biomarker for Rheumatoid Arthritis Disease Activity

Abdelsalam¹,

Mohamed²,

Abdellatif³

et al. 2018

TORJ

View full text Add to dashboard Cite

Background:Rheumatoid arthritis is a chronic inflammatory autoimmune disease characterized by destruction of the joint cartilage and bone. Endothelial dysfunction (ED) in RA may be related to disease activity. Our objective is to explore serum levels of endothelial cell-specific molecule-1 (ESM-1) as a biomarker for RA disease activity.Methods:A cross-sectional study was carried out and included 83 adult patients with RA, in addition to 20 healthy subjects (age and sex-matched) as a control group. Based on Disease Activity Score in 28 joints (DAS-28), the patient's group was subdivided into four subgroups(remission, mild, moderate and severe disease activity state). The demographic & clinical data, BMI, DAS-28 and Serological assessment [Erythrocyte Sedimentation Rate (ESR), CRP, Rheumatoid Factor (RF) and Anti-Citrullinated Peptide Antibody (ACPA)] were recorded. ESM-1was assayed for all participants.Results:Serum levels of ESM1 were significantly higher in the patient group than the control group (P< 0.0001). ESM-1 serum levels were significantly higher in patients with severe disease activity subgroup compared with patients with remission and mild disease activity subgroups (P< 0.0001). ESM-1 was positively and significantly correlated with DAS-28 score, The Health Assessment Questionnaire Disability Index (HAQ-DI) and modified Larsen score (P= 0.002, 0.0001 & 0.0001 respectively).Conclusion:ESM-1 could be a biomarker for RA disease activity.

show abstract

Section: Das Esm1supporting

confidence: 90%

Section: Das Esm1mentioning

confidence: 69%

Serum Level of Endothelial Cell-Specific Molecule -1 (ESM -1) as a New Potential Biomarker for Rheumatoid Arthritis Disease Activity

Abdelsalam¹,

Mohamed²,

Abdellatif³

et al. 2018

TORJ

View full text Add to dashboard Cite

show abstract

“…Our results coincided with those of Abdelsalam et al [23] who found serum endocan levels positively correlated with disease activity (DAS-28), HAQ-DI, ESR, CRP modified Larsen score, and RF levels. Another study reported the same results in JIA but failed to report correlation with the severity of inflammation [27]. Others reported that ESM-1 was elevated and correlated with ESR and CRP in Behcet's disease [25], systemic lupus erythematosus [21], systemic sclerosis [28] & inflammatory bowel disease [29].…”

Section: Discussionmentioning

confidence: 89%

Endocan as an Early Predictor of Endothelial Dysfunction and Atherosclerosis in Egyptian Patients with Rheumatoid Arthritis.

Gadow,

El-Banna,

Abd Elwahab

et al. 2023

RBJ

View full text Add to dashboard Cite

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Inflammation leads to endothelial cells activation. Activated endothelial cells with increased leukocytes adhesion molecules expression, which can induce endothelial dysfunction (ED) and atherosclerosis. Aim: to measure the serum level of Human endothelial cell-specific molecule-1 (endocan) in patients with rheumatoid arthritis and to evaluate its relation to endothelial dysfunction and atherosclerosis. Materials and methods: the study included 30 consecutive RA patients, and 30 healthy control subjects. RA disease activity was measured by the DAS-28 score. Serum endocan was measured by enzyme-linked immunosorbent assay (ELISA). The collected data were statistically analyzed using SPSS program version 16. Results: There was a significant elevation in Endocan level in RA patients (1.81 ± 0.66 ng/ml) compared to control group (1.41 ± 0.59ng/ml) (P= 0.012). Serum endocan levels showed significant positive correlation with disease activity score-28(DAS-28), ESR, CRP, LDL and carotid intima media thickness (cIMT) (P = 0.015, 0.004, <0.001, 0.008, 0.005 respectively). Linear regression analysis revealed that the serum endocan level, age and disease activity were independent predictors for cIMT, and atherosclerosis development in RA patients. Conclusion: Endocan is a useful marker to predict endothelial dysfunction and atherosclerosis in patients with rheumatoid arthritis.

show abstract

“…[41][42][43][44][45][46][47][48][49] In pediatric populations, recent studies reported high serum endocan levels in patients with necrotizing enterocolitis and juvenile idiopathic arthritis in the neonatal period. 50,51 But to the best of our knowledge, there is no study in a pediatric population assessing the risk of atherosclerosis in obese patients using endocan and cIMT.…”

Section: Discussionmentioning

confidence: 99%

Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children

et al. 2021

View full text Add to dashboard Cite

Obesity in children appears to be associated with increased risk of cardiovascular and metabolic diseases later in life. Early development of insulin resistance (IR) may lead to endothelial dysfunction and increased carotid intima–media thickness (cIMT) even in childhood. We compared endothelial cell-specific molecule-1 (endocan) levels in pediatric obese patients with those in healthy controls to determine whether endocan could be used as a biological marker of complications caused by endothelial damage. In 80 obese pubertal children (44 males [M] and 36 females [F], mean age: 12.8 ± 2.5 years), anthropometric measurements, cIMT, endocan levels, and IR indices (homeostasis model assessment of insulin resistance [HOMA-IR]) were evaluated and compared with 80 healthy pubertal patients (42M/38F, mean age: 12.3 ± 3.2 years). High-resolution ultrasound was used to measure the cIMT. Obese children had higher levels of endocan compared with the controls ( P < .001). Fasting insulin levels and HOMA-IR were also higher in obese children ( P < .001 for both). In addition, obese children had an increased cIMT ( P < .001). In obese children, there was a significant correlation between cIMT and HOMA-IR (β = −1.314, P = .002) and between cIMT and endocan (β = .483, P = .004). Measuring cIMT and endocan levels (noninvasive investigations) in obese children, together with early preventive measures, could significantly decrease morbidity and mortality in adulthood.

show abstract

The Assessment of Serum Endocan Levels in Children With Juvenile Idiopathic Arthritis

Cited by 8 publications

References 19 publications

Serum Level of Endothelial Cell-Specific Molecule -1 (ESM -1) as a New Potential Biomarker for Rheumatoid Arthritis Disease Activity

Serum Level of Endothelial Cell-Specific Molecule -1 (ESM -1) as a New Potential Biomarker for Rheumatoid Arthritis Disease Activity

Endocan as an Early Predictor of Endothelial Dysfunction and Atherosclerosis in Egyptian Patients with Rheumatoid Arthritis.

Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children

Contact Info

Product

Resources

About