The assessment of serum lipid profiles of children with attention deficit hyperactivity disorder

Uğur, Çağatay; Üneri, Özden Şükran; Göker, Zeynep; Sekmen, Ebru; Aydemir, Hilal; Solmaz, Esra

doi:10.1016/j.psychres.2018.04.006

Cited by 13 publications

(8 citation statements)

References 43 publications

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“…First, our study data are from the cross-sectional analysis with a large sample size. 18 , 19 The analysis of the results suggested that elevated levels of blood lipids were closely related to ADHD among nonobese children, which expands national sample research on the association. Second, our results demonstrated that obesity is an important modifying variable that affects the association between blood lipid levels and ADHD.…”

Section: Discussionmentioning

confidence: 74%

“…In the study, all children with ADHD were included if they had at least one registered diagnosis of ADHD. The diagnostic criteria for ADHD include the following: 19 1) the onset of ADHD is at or before the age of 7; 2) the symptoms of ADHD must manifest in two or more environments, such as school, workplace or home; 3) there is clear clinical impairment in social, academic or occupational functions; and 4) generalized developmental disorder, schizophrenia, emotional disorder or other mental disorders should be excluded. All included children met these 4 criteria.…”

Section: Methodsmentioning

confidence: 99%

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The Relationship Between Blood Lipid and Attention-Deficit/Hyperactivity Disorder (ADHD) in an Obese Population of Chinese Children: An Obesity-Stratified Cross-Sectional Study

Yan¹,

Bao²,

Liu³

2021

IJGM

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Background Although obesity has been related to attention-deficit/hyperactivity disorder (ADHD), few studies have examined the relationship between blood lipid levels and ADHD in children. We aimed to evaluate whether increased blood lipid levels are associated with the prevalence of ADHD in children. Methods A total of 1179 children were studied in the cross-sectional analysis. Multivariate logistic regression and linear regression analyses were performed to evaluate the association of blood lipid levels with the prevalence of ADHD in children. Results In 1179 children, the average age was 10.4 years, and the percentage of boys was 50.3%. 97 (8.2%) of the children were diagnosed with ADHD. The logistic regression analysis demonstrated that elevated levels of total cholesterol (OR=2.001, 95% CI 1.247–3.541, P -trend=0.024), triglycerides (OR=1.776, 95% CI 1.448–2.187, P -trend=0.003) and LDL (low density lipoprotein; OR=2.016, 95% CI 1.335–3.966, P -trend<0.001) and reduced levels of HDL (high density lipoprotein; OR=0.577, 95% CI 0.298–0.948, P -trend=0.023) were associated with the prevalence of ADHD after adjustments were made for age, sex, body mass index (BMI), residence type, maternal smoking during pregnancy, breastfeeding and breastfeeding length, maternal and paternal educational levels, and marital status of parents in Model 3. The stratified analysis using “obese” as a covariate showed that elevated levels of total cholesterol, triglycerides and LDL and reduced levels of HDL were independently associated with an increased risk of ADHD in obese children. Conclusion Increased blood lipid levels were associated with ADHD in obese children.

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Section: Discussionmentioning

confidence: 74%

Section: Methodsmentioning

confidence: 99%

The Relationship Between Blood Lipid and Attention-Deficit/Hyperactivity Disorder (ADHD) in an Obese Population of Chinese Children: An Obesity-Stratified Cross-Sectional Study

Yan¹,

Bao²,

Liu³

2021

IJGM

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“…What’s more, studies have shown that people with ADHD have a diet high in lipids, and that high total serum cholesterol and low-density lipoprotein are likely to contribute to the development of ADHD. Cholesterol circulating in the blood does not cross the blood–brain barrier and is not utilized by the central nervous system, and elucidating both the etiology and dietary control could help develop more effective treatments ( Ugur et al, 2018 ). Lipids may not only be used to diagnose mental disorders, but may also be a cause of mental disorders ( Grela et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021

Zhao

Meng²,

Cao³

et al. 2023

Front. Microbiol.

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BackgroundAn increasing number of studies have focused on the role of gut microbiota in the treatment of ADHD, but its related molecular mechanisms are not yet clear, and there is still room for development of studies targeting this area. This study analyzes publications from 2012 to 2021 in a comprehensive and multi-faceted visualization, with the aim of grasping the existing research profile and guiding scholars to make more in-depth studies.MethodsThe 1,677 articles and 298 review articles on gut microbiota in ADHD were retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, Microsoft Excel 2019, Scimago Graphica, Bibliometrix and Pajek metrics software were used for visualization and analysis of the included literature.ResultsOn August 3, 2022, a total of 1975 English-language articles on gut microbiota in ADHD were retrieved from Web of Science Core Collection (WoSCC) from January 2012 to December 2021, with a steady upward trend in the number of articles published in this field over the decade. The top three countries in terms of the number of articles published are the United States, China, and Spain. Meanwhile, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS CSIC, UNIV OF CALIFORNIA SYSTEM, and UDICE FRENCH RESEARCH UNIV have made significant contributions in this field. In the analysis of the published journals, PLoS One was not only the first in terms of number of articles published but also the most cited. Wang J was the most prolific author and CAPORASO JG ranked first in terms of co-cited authors. In addition, “Diet rapidly and reproducibly alters the human gut microbiome,” published by David LA et al., has the highest citation frequency in this field. The most frequently occurring keyword was “gut microbiota.”ConclusionThe results of this paper clarify the current status of research on gut microbiota in ADHD. Based on the research on the mechanism of gut microbiota in other diseases, there is reason to believe that the exploration of gut microbiota in ADHD must be increasingly mature. And the study speculates that future research may focus on “nutrition supplements,” “lipid metabolism,” and “gut brain axis.” It is imperative to promote a closer international cooperation among scholars in this field.

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“…3 ). As an opposite report, serum total Chl and LDL levels were increased in children with ADHD, but there were no correlations of clinical evaluation [ 95 ]. In Fragile X syndrome, decreases in total Chl, LDL, and HDL were reported [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction

et al. 2020

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Background Abnormalities of lipid metabolism contributing to the autism spectrum disorder (ASD) pathogenesis have been suggested, but the mechanisms are not fully understood. We aimed to characterize the lipid metabolism in ASD and to explore a biomarker for clinical evaluation. Methods An age-matched case-control study was designed. Lipidomics was conducted using the plasma samples from 30 children with ASD compared to 30 typical developmental control (TD) children. Large-scale lipoprotein analyses were also conducted using the serum samples from 152 children with ASD compared to 122 TD children. Data comparing ASD to TD subjects were evaluated using univariate (Mann-Whitney test) and multivariate analyses (conditional logistic regression analysis) for main analyses using cofounders (diagnosis, sex, age, height, weight, and BMI), Spearman rank correlation coefficient, and discriminant analyses. Findings Forty-eight significant metabolites involved in lipid biosynthesis and metabolism, oxidative stress, and synaptic function were identified in the plasma of ASD children by lipidomics. Among these, increased fatty acids (FAs), such as omega-3 (n-3) and omega-6 (n-6), showed correlations with clinical social interaction score and ASD diagnosis. Specific reductions of very-low-density lipoprotein (VLDL) and apoprotein B (APOB) in serum of ASD children also were found by large-scale lipoprotein analysis. VLDL-specific reduction in ASD was correlated with APOB, indicating VLDL-specific dyslipidaemia associated with APOB in ASD children. Interpretation Our results demonstrated that the increases in FAs correlated positively with social interaction are due to VLDL-specific degradation, providing novel insights into the lipid metabolism underlying ASD pathophysiology. Funding This study was supported mainly by MEXT, Japan.

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The assessment of serum lipid profiles of children with attention deficit hyperactivity disorder

Cited by 13 publications

References 43 publications

The Relationship Between Blood Lipid and Attention-Deficit/Hyperactivity Disorder (ADHD) in an Obese Population of Chinese Children: An Obesity-Stratified Cross-Sectional Study

The Relationship Between Blood Lipid and Attention-Deficit/Hyperactivity Disorder (ADHD) in an Obese Population of Chinese Children: An Obesity-Stratified Cross-Sectional Study

A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021

VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction

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