The Assessment of the Usefulness of Platelet-Rich Fibrin in the Healing Process Bone Resorption

Abstract

The main subject of this research was the use of PRF in dental surgery aimed at preventing changes in alveolar height and width after tooth extraction. Due to the large growth factor content, it seems to be particularly useful in bone loss management starting from the simplest loss occurring after tooth extraction through loss resulting from tooth resection ending with loss caused by large bone cysts. The study was performed on 50 patients. The extraction of two maxillary or mandibular homonymous teeth was carried out in each patient, where PRF was placed in one alveolus while the other alveolus was left empty. Then, the alveoli were surgically managed with a split flap technique. On the extraction day, after 10 days, and after 6 months, the alveolar process was measured, soft tissues healing was assessed, and imaging examinations were analyzed. It was proved that the healing of soft tissues in the PRF group was better. In the PRF group after 6 months from surgery, the newly formed bone had higher grayscale values in volumetric tomography (CBCT). Moreover, the reduced atrophy of the alveolar process at the site of the extracted tooth was proved in this study.

Imaging Evaluation of Platelet-Rich Fibrin in Post-Exodontic Bone Regeneration: A Systematic Review

“…This review analyzed 17 parallel RCTs. Thirteen studies compared PRF treatment alone with physiological healing or blood clotting without additional treatment [1][2][3]5,13,14,17,19,20,22,[26][27][28][29][30]. One study included three groups and compared the use of PRF and PRF with mucosal flap with spontaneous healing [21].…”

“…Patients were mainly studied with or without requiring dental exodontia (including the third molar) and/or implants were required for some but not all of the patients included in the studies [1,3,5,10,13,14,17,[19][20][21][22][26][27][28][29][30]. Additionally, some studies focused only on uniradicular teeth or premolars [2,10,21,26] (Table 3).…”

“…Most studies did not report or specify the treated socket and/or ridge morphology. All studies reported the presence of 50% buccal and/or lingual bone walls [1,3,5,10,13,14,17,[19][20][21][22][26][27][28][29][30]. Most studies reported traumatic exodontia [1][2][3]5,10,13,17,[19][20][21][22][26][27][28][29][30]…”

“…All studies reported the presence of 50% buccal and/or lingual bone walls [1,3,5,10,13,14,17,[19][20][21][22][26][27][28][29][30]. Most studies reported traumatic exodontia [1][2][3]5,10,13,17,[19][20][21][22][26][27][28][29][30]…”

Advanced Biomaterials, Coatings, and Techniques: Applications in Medicine and Dentistry

“…It promotes tissue regeneration and reduces healing time by increasing the local concentration of growth factors, and has been frequently used in combination with bone graft materials in maxillofacial and orthopaedic surgery and sports-related injuries [17][18][19][20][21][22][23]. It has excellent handling characteristics, and can be firmly sutured in an anatomically desired location during open surgery [24][25][26].…”