The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly

İlhan, Muzaffer; Turgut, Seda; Turan, Saime; Çekiç, Sema Demirci; Ergen, Arzu; Dursun, G; Mezani, Brunilda; Karaman, Ozcan; Yaylım, İlhan; Apak, Mustafa; Taşan, Ertuğrul

doi:10.1507/endocrj.ej17-0300

Cited by 9 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Monocyte-derived macrophages that invaded the vascular wall are stimulated to form foam cells, which further fuels vascular wall inflammation and damage. Indeed, Boero et al reported increased levels of oxLDL in active acromegaly patients and increased oxidative stress, which was also suggested by others [113,115,117], although increased oxidative stress or a reduced oxidative capacity was not observed in all studies [118].…”

Section: Endothelial Dysfunction and Microvascular Inflammation In Acmentioning

confidence: 56%

Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of cardiovascular disease (CVD), and numerous cardiovascular risk factors remain present after remission. GH and IGF-1 have numerous effects on the immune and cardiovascular system. Since endothelial damage and systemic inflammation are strongly linked to the development of CVD, and have been suggested to be present in both controlled as uncontrolled acromegaly, they may explain the presence of both micro- and macrovascular dysfunction in these patients. In addition, these changes seem to be only partially reversible after remission, as illustrated by the often reported presence of endothelial dysfunction and microvascular damage in controlled acromegaly. Previous studies suggest that insulin resistance, oxidative stress, and endothelial dysfunction are involved in the development of CVD in acromegaly. Not surprisingly, these processes are associated with systemic inflammation and respond to GH/IGF-1 normalizing treatment.

show abstract

Section: Endothelial Dysfunction and Microvascular Inflammation In Acmentioning

confidence: 56%

Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

View full text Add to dashboard Cite

show abstract

“…Regarding the relationship between urinary TAC levels and plasma SOD levels, accumulating evidence indicates that the imbalance between oxidative stress-induced reactive oxygen species and urinary TAC levels correlates with ASD. A previous report demonstrated that SOD levels were higher in autistic children than in typically developed children, and this increase was associated with the up-regularized expression of nitrotyrosine, a marker of oxidative damage, in the immune cells of ASD subjects (60). Of reference, plasma SOD may affect urinary TAC activity (10).…”

Section: Discussionmentioning

confidence: 96%

Urinary and Plasma Antioxidants in Behavioral Symptoms of Individuals With Autism Spectrum Disorder

et al. 2021

View full text Add to dashboard Cite

The balance between antioxidant capacity and oxidative stress-induced free radicals may be crucial in the pathophysiological development factor of autism spectrum disorder (ASD). We measured the following urinary and plasma biomarker levels of oxidative stress and antioxidants. As urinary biomarkers, (1) hexanoyl-lysine (HEL), which is a new biomarker of oxidative stress, (2) the total antioxidant capacity (TAC), and (3) 8-hydroxy-2′-deoxyguanosine (8-OHdG), as a product of oxidative modifications to DNA; and the plasma levels of (4) the antioxidant protein superoxide dismutase (SOD), which is the crucial defense again oxygen reactive species, and (5) transferrin and (6) ceruloplasmin, which are biomarkers of iron and copper neurotransmission and oxidant-antioxidant systems. We examined the relationship between these urinary and plasma biomarkers and behavioral symptoms in 19 individuals with ASD (mean age, 10.8 ± 5.2 years) and 10 age-matched healthy controls (mean age, 14.2 ± 7.0 years). Behavioral symptoms were estimated using the Aberrant Behavior Checklist (ABC). Urinary TAC levels were significantly lower, whereas urinary HEL levels were significantly increased in the ASD group as compared with the control group. The five ABC subscale and total scores were significantly raised in the autism group than in the control group. The results of a linear regression analysis revealed that plasma SOD levels may be a more accurate predictor of differences in ABC scores between individuals with ASD and control individuals. The present study firstly revealed the important findings that the cooperation between the urinary antioxidant TAC and plasma SOD levels may contribute to the ABC subscale scores of stereotypy. Urinary TAC activity and antioxidant protein SOD may be associated with incomplete mineral body store and antioxidant-related transcription factor and browning reactions. Consequently, a critical imbalance between TAC urinary levels and plasma SOD levels may be an important contributor to autistic behavioral symptoms.

show abstract

“…H 2 O 2 can be scavenged by GPX's (glutathione peroxidases) and peroxiredoxins (thioredoxindependent peroxidases) (Chu et al, 2004;Kang et al, 2005). Studies have found that the levels of CuZnMOD and MnSOD are significantly lower in PAs compared to those of controls (Kurisaka et al, 2004;Yang et al, 2012;Ilhan et al, 2018). The abnormal activities of these antioxidant enzymes and non-enzymatic antioxidants are directly associated with carcinogenesis (Neumann et al, 2003;Chu et al, 2004;Harris et al, 2015).…”

Section: Redox Homeostasis and Nrf2 As The Heart Of Oxidative Stress Responsementioning

confidence: 99%

“…Further studies show that AIP interacts with antioxidants, chaperone and stress response-related proteins, and cytoskeletal proteins, including HSPA5, HSPA9, HSP90AA1, HSP90AB1, HSPA8, SOD1, TUBB, TUBB2A, and NME1; AIP variants show the impaired interaction of AIP with HSPA8, HSP90AB1, NME1, SOD1, TUBB, and TUBB2A; AIP-mutated PAs show the reduced expression of TUBB2A (Cuadrado et al, 2019). The levels of MnSOD and total antioxidant capability (TAC) are significantly decreased in GH-secreting PAs (Ilhan et al, 2018). The frequencies of micronuclei (MN), nucleoplasmic bridges, nuclear buds, apoptotic and necrotic cells, and plasma 8hydroxy-2′-deoxyguanosine (8-OHdG) levels in peripheral blood lymphocytes are significantly increased in PRL-secreting PAs, which indicates the increased oxidative damage in PRL-secreting PAs (Bitgen et al, 2016).…”

Section: Nrf2-mediated Oxidative Stress Response Signaling Pathways In Pasmentioning

confidence: 99%

Targeting Nrf2-Mediated Oxidative Stress Response Signaling Pathways as New Therapeutic Strategy for Pituitary Adenomas

Zhan

Zhou

2021

Front. Pharmacol.

View full text Add to dashboard Cite

Oxidative stress and oxidative damage are the common pathophysiological characteristics in pituitary adenomas (PAs), which have been confirmed with many omics studies in PA tissues and cell/animal experimental studies. Nuclear factor erythroid 2 p45-related factor 2 (Nrf2), the core of oxidative stress response, is an oxidative stress sensor. Nrf2 is synthesized and regulated by multiple factors, including Keap1, ERK1/2, ERK5, JNK1/2, p38 MAPK, PKC, PI3K/AKT, and ER stress, in the cytoplasm. Under the oxidative stress status, Nrf2 quickly translocates from cytoplasm into the nucleus and binds to antioxidant response element /electrophile responsive element to initiate the expressions of antioxidant genes, phases I and II metabolizing enzymes, phase III detoxifying genes, chaperone/stress response genes, and ubiquitination/proteasomal degradation proteins. Many Nrf2 or Keap1 inhibitors have been reported as potential anticancer agents for different cancers. However, Nrf2 inhibitors have not been studied as potential anticancer agents for PAs. We recommend the emphasis on in-depth studies of Nrf2 signaling and potential therapeutic agents targeting Nrf2 signaling pathways as new therapeutic strategies for PAs. Also, the use of Nrf2 inhibitors targeting Nrf2 signaling in combination with ERK inhibitors plus p38 activators or JNK activators targeting MAPK signaling pathways, or drugs targeting mitochondrial dysfunction pathway might produce better anti-tumor effects on PAs. This perspective article reviews the advances in oxidative stress and Nrf2-mediated oxidative stress response signaling pathways in pituitary tumorigenesis, and the potential of targeting Nrf2 signaling pathways as a new therapeutic strategy for PAs.

show abstract

The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly

Cited by 9 publications

References 41 publications

Acromegaly, inflammation and cardiovascular disease: a review

Acromegaly, inflammation and cardiovascular disease: a review

Urinary and Plasma Antioxidants in Behavioral Symptoms of Individuals With Autism Spectrum Disorder

Targeting Nrf2-Mediated Oxidative Stress Response Signaling Pathways as New Therapeutic Strategy for Pituitary Adenomas

Contact Info

Product

Resources

About