The assessment of Tp‐e interval and Tp‐e/QT ratio in patients with hyperthyroidism before and after thyroid surgery

Aydin, Altan; Yayla, Kadriye Gayretli̇

doi:10.1111/ijcp.14937

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…In a study by Aydin et al, the comparison of the preoperative and postoperative Tp-e levels of hyperthyroid patients revealed an improvement in the Tp-e levels after surgical treatment. It is worth noting that patients in both groups were euthyroid and received medical treatment [22]. Accordingly, Graves' disease may increase susceptibility to arrhythmia independently of thyroid hormone level as well.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Tpeak-Tend Interval as an Arrhythmogenicity Index in Graves' Disease

2023

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Introduction.Graves’ disease is the most common cause of hyperthyroidism. The mortality rate increases by 20% in hyperthyroid patients; cardiac problems are the leading cause of death and arrhythmia is the most common cardiac complication. Our study aimed to evaluate the corrected QT interval (QTc), the Tpeak-Tend interval (Tp-e), and the Tp-e/QTc ratio to predict arrhythmia risk in patients with Graves’ disease. Methods. The study included 64 patients with Graves’ disease and 57 euthyroid controls. The 12-lead electrocardiograms of the individuals under study were evaluated. The QTc interval, the Tp-e interval, and the Tp-e/QTc ratio of all participants were determined and statistically evaluated with thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) values. Results. Tp-e (p < 0.001) and QTc (p < 0.05) were significantly prolonged in the group of patients with Graves’ disease as compared to the control group. Heart rate was higher in patients with Graves’ disease as well (p < 0.05). Correlation analysis in patients with hyperthyroidism demonstrated that Tp-e (r=0.372, p=0.002), QTc (r=0.291, p=0.020), and fT3 levels were significantly and positively correlated. Similarly, Tp-e (r=0.271, p=0.030), QTc (r=0.259, p=0.039), and fT4 levels were significantly and positively correlated. Conclusions. We observed a significant prolongation of the Tp-e and QTc intervals with the increase in fT3 and fT4 levels. On the other hand, our study demonstrated that the sensitivity and specificity of Tp-e in the prediction of hyperthyroidism were 70.3% and 70.1%, respectively (AUC=0.724 (CI: 0.629-0.818)), the optimal cut-off value=83.5 ms). The Tp-e interval, which has recently been used as one of the arrhythmogenicity indices, may be an indicator of arrhythmia risk in patients with Graves’ disease.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Tpeak-Tend Interval as an Arrhythmogenicity Index in Graves' Disease

2023

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“…Ventricular repolarization markers such as Tp-e interval, Tp-e/ QT, and Tp-e/QTc ratios have been evaluated in many clinical situations [10][11][12][13][14] . The Tp-e interval may represent the transmural distribution of repolarization, and an increased Tp-e interval is associated with malignant ventricular arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

The relationship between premature ventricular complexes and index of cardiac-electrophysiological balance

Adalı

Davutoglu

Yılmaz

2023

Rev. Assoc. Med. Bras.

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OBJECTIVE: Premature ventricular complexes are common in healthy individuals' ambulatory monitoring. The index of cardiac-electrophysiological balance may predict malignant ventricular arrhythmias. This study investigated the relation between Premature ventricular complex burden and index of cardiac-electrophysiological balance in 24-h Holter monitoring. METHODS: A total of 257 patients who were admitted to a cardiology outpatient clinic without structural heart disease and underwent 24-h Holter monitoring were included in the study. Demographic features, laboratory parameters, and electrocardiographic and echocardiographic values of all patients were obtained from the hospital database. Patients were categorized into the following four groups according to their premature ventricular complex burden: ≤5% premature ventricular complexes as group 1, >6 and ≤10% premature ventricular complexes as group 2, >11 and ≤20% premature ventricular complexes as group 3, and >20% premature ventricular complexes as group 4. QRS, QT, and T peak to end interval were measured by resting electrocardiography. QT interval was corrected using Bazett's formula. T peak to end interval/QT, T peak to end interval/corrected QT interval, index of cardiac-electrophysiological balance, and corrected index of cardio-electrophysiological balance ratios were calculated. RESULTS: There was no significant difference between groups regarding cardiovascular risk factors. In group 4, beta-blocker usage was significantly higher, and the serum magnesium levels were significantly lower than in other groups. There was no difference in QT duration or index of cardiacelectrophysiological balance values; however, corrected index of cardio-electrophysiological balance was significantly lower in the highest premature ventricular complex group (5.1, 5.1, 4.8, 4.7, p=0.005). In multivariate backward logistic regression analyses, it was found that lower corrected index of cardio-electrophysiological balance, lower serum magnesium levels, lower serum creatinine levels, larger left atrium size, and higher T peak to end interval were associated with higher premature ventricular complexes. CONCLUSION: Corrected index of cardio-electrophysiological balance is a novel and noninvasive marker that can predict premature ventricular complex burden in patients with structurally normal hearts.

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Section: Dear Editormentioning

confidence: 99%

“…6 Also, Aydin et al showed that the Tp-e interval, as well as the Tp-e/QT and Tp-e/QTc ratios, was shortened in patients with hyperthyroidism after thyroid surgery; QT dispersion was also significantly different before and after thyroid surgery. 7 Is there any data about the QT dispersion in the Hepsen et al study? 1 What was the success rate for all surgical procedures?…”

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confidence: 98%

Letter: Arrhythmias in Patients with Hyperthyroidism

Yayla

Aydin³

2021

Angiology

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We read the article entitled "The Assessment of Ventricular Arrhythmia Indicators Based on Electrocardiography in Patients With Differentiated Thyroid Cancer Followed Up With Levothyroxine Suppression" by Hepsen et al. with interest. 1 Several studies described the relationship between hyperthyroidism and ventricular arrhythmias. [1][2][3][4] A study of patients with a mean age of 20 years showed that hyperthyroidism was associated with QTc prolongation. 5 Hyperthyroidism has also been related with QT dispersion. 6 Also, Aydin et al. showed that the Tp-e interval, as well as the Tp-e/QT and Tp-e/QTc ratios, was shortened in patients with hyperthyroidism after thyroid surgery; QT dispersion was also significantly different before and after thyroid surgery. 7 Is there any data about the QT dispersion in the Hepsen et al. study? 1 What was the success rate for all surgical procedures? Could this information affect the study results?

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The assessment of Tp‐e interval and Tp‐e/QT ratio in patients with hyperthyroidism before and after thyroid surgery

Cited by 5 publications

References 33 publications

Evaluation of the Tpeak-Tend Interval as an Arrhythmogenicity Index in Graves' Disease

Evaluation of the Tpeak-Tend Interval as an Arrhythmogenicity Index in Graves' Disease

The relationship between premature ventricular complexes and index of cardiac-electrophysiological balance

Letter: Arrhythmias in Patients with Hyperthyroidism

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