The Associason of Vitamin D Receptor Gene (Vdr) Polymorphisms With High Blood Pressure in Stroke Patients of Ukrainian Population

Abstract

The aim: To study the association of the polymorphisms VDR gene with high blood pressure in stroke patients in the Ukrainian population. Materials and methods: Venous blood of 170 patients with atherothrombotic ischemic stroke (AIS) and 124 healthy individuals (control group) was used for genotyping. Four polymorphisms (FokI, BsmI, ApaI, TaqI) of gene VDR were examined with PCR-RFLP methodology. Statistical analysis was performed by using SPSS-17.0 program. Results: The correlation of genotypes of polymorphic variants of FokI, BsmI, ApaI and TaqI of the VDR gene with the development of ischemic atherothrombotic stroke in individuals with normal and high blood pressure was detected. Statistical analysis of the obtained data revealed that among carriers of genotypes F/F, b/b, a/a, a/A, and T/T patients with AI have statistically significantly higher incidence of hypertension than patients in the control group. Conclusions: It was found that persons with genotypes F/F, b/b, a/a, a/A, and T/T showed a statistically significant relationship between hypertension and the development of IAS. The application of logistic regression has made it possible to establish that the risk of IAS in people with normal blood pressure and genotype F/f is 3.2 times higher than in normotensive homozygotes for the F-allele.

Vitamin D deficiency and the vitamin D receptor (VDR) gene polymorphism rs2228570 (FokI) are associated with an increased susceptibility to hypertension among the Bangladeshi population

“…On the contrary, genotype frequencies of control subjects were found to be 9.0%, 56.0% and 35.0% respectively ( Table 3 ). Interestingly, VDR gene FokI showed significant difference (p <0.01) between the hypertensive patients and healthy controls which is partly associated with several studies performed worldwide [ 31 , 36 ].…”

Vitamin D receptor gene polymorphisms and the effectiveness of assisted reproductive technology

“…Важно отметить, что для правильного функционирования биологических систем организма человека в равной степени важным является как присутствие в достаточной концентрации биологически активной молекулы (кальцитриол), так и должное функционирование рецептора (VDR). В литературе присутствуют сведения о роли полиморфизмов VDR в развитии сердечно-сосудистых [7], онкологических [8,9], ревматологических и аутоиммунных заболеваний [10,11] и других патологических состояний. Тем не менее роль полиморфизмов гена VDR в репродукции человека изучена недостаточно.…”