The associated burden of mental health conditions in alopecia areata: a population‐based study in
            <scp>UK</scp>
            primary care*

Macbeth, A. E.; Holmes, Susan; Harries, Matthew; Chiu, Wing Sin; Tziotzios, Christos; Lusignan, Simon de; Messenger, A.G.; Thompson, Andrew R.

doi:10.1111/bjd.21055

Cited by 42 publications

(52 citation statements)

References 28 publications

(59 reference statements)

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“…Eight papers studied the prevalence of anxiety disorders in adults with AA ( n = 86,014). These studies reported point prevalence rates of 3.24% ( 64 ), 4% ( 17 ), 8.4% ( 71 ), and 13.70% ( 58 ). Several papers also reported that people with AA have a higher chance of being diagnosed with an anxiety disorder in comparison to healthy controls ( 13 , 15 , 17 , 64 ).…”

Section: Resultsmentioning

confidence: 99%

“…These studies reported point prevalence rates of 3.24% ( 64 ), 4% ( 17 ), 8.4% ( 71 ), and 13.70% ( 58 ). Several papers also reported that people with AA have a higher chance of being diagnosed with an anxiety disorder in comparison to healthy controls ( 13 , 15 , 17 , 64 ). Prevalence rates of specific anxiety disorders in people with AA range from 7.4% for specific phobias and 22.2–39% for generalized anxiety disorders ( 57 , 66 ).…”

Section: Resultsmentioning

confidence: 99%

“…The largest and most recent study found a point prevalence of 9.5% ( 71 ). Furthermore, adults with AA have a higher chance of being diagnosed with a depressive disorder than healthy controls ( 13 , 15 , 17 , 64 ). One study did not find any difference in the number of diagnoses ( 58 ).…”

Section: Resultsmentioning

confidence: 99%

“…Several papers also reported that people with AA have Forest plot for symptoms of anxiety in adults with alopecia compared to healthy controls. a higher chance of being diagnosed with an anxiety disorder in comparison to healthy controls (13,15,17,64). Prevalence rates of specific anxiety disorders in people with AA range from 7.4% for specific phobias and 22.2-39% for generalized anxiety disorders (57, 66).…”

Section: Adultsmentioning

confidence: 99%

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Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Dalen

Muller

Kasperkovitz-Oosterloo³

et al. 2022

Front. Med.

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IntroductionAlopecia areata (AA) is a non-scarring hair loss condition, subclassified into AA, alopecia universalis, and alopecia totalis. There are indications that people with AA experience adverse psychosocial outcomes, but previous studies have not included a thorough meta-analysis and did not compare people with AA to people with other dermatological diagnoses. Therefore, the aim of this systematic review and meta-analysis was to update and expand previous systematic reviews, as well as describing and quantifying levels of anxiety, depression, and quality of life (QoL) in children and adults with AA.MethodsA search was conducted, yielding 1,249 unique records of which 93 were included.ResultsReview results showed that people with AA have higher chances of being diagnosed with anxiety and/or depression and experience impaired QoL. Their psychosocial outcomes are often similar to other people with a dermatological condition. Meta-analytic results showed significantly more symptoms of anxiety and depression in adults with AA compared to healthy controls. Results also showed a moderate impact on QoL. These results further highlight that AA, despite causing little physical impairments, can have a significant amount on patients’ well-being.DiscussionFuture studies should examine the influence of disease severity, disease duration, remission and relapse, and medication use to shed light on at-risk groups in need of referral to psychological care.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022323174].

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Adultsmentioning

confidence: 99%

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Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Dalen

Muller

Kasperkovitz-Oosterloo³

et al. 2022

Front. Med.

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“…In this issue of the BJD , Macbeth and her seven coauthors provide a timely article regarding mental health conditions associated with alopecia areata (AA) 1 . In the past, this area has been neglected by many dermatologists and others when considering the treatment of AA, a problem we discussed nearly 20 years ago 2 .…”

mentioning

confidence: 99%

Identity and psychological distress in alopecia areata

Hunt

2022

Br J Dermatol

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The Alopecia Areata Severity and Morbidity Index (ASAMI) Study

Moussa,

Bennett,

Wall

et al. 2024

JAMA Dermatol

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ImportanceCurrent measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact.ObjectiveTo explore factors associated with AA severity beyond scalp hair loss, and to support the development of the Alopecia Areata Severity and Morbidity Index (ASAMI).Evidence ReviewA total of 74 hair and scalp disorder specialists from multiple continents were invited to participate in an eDelphi project consisting of 3 survey rounds. The first 2 sessions took place via a text-based web application following the Delphi study design. The final round took place virtually among participants via video conferencing software on April 30, 2022.FindingsOf all invited experts, 64 completed the first survey round (global representation: Africa [4.7%], Asia [9.4%], Australia [14.1%], Europe [43.8%], North America [23.4%], and South America [4.7%]; health care setting: public [20.3%], private [28.1%], and both [51.6%]). A total of 58 specialists completed the second round, and 42 participated in the final video conference meeting. Overall, consensus was achieved in 96 of 107 questions. Several factors, independent of the Severity of Alopecia Tool score, were identified as potentially worsening AA severity outcomes. These factors included a disease duration of 12 months or more, 3 or more relapses, inadequate response to topical or systemic treatments, rapid disease progression, difficulty in cosmetically concealing hair loss, facial hair involvement (eyebrows, eyelashes, and/or beard), nail involvement, impaired quality of life, and a history of anxiety, depression, or suicidal ideation due to or exacerbated by AA. Consensus was reached that the Alopecia Areata Investigator Global Assessment scale adequately classified the severity of scalp hair loss.Conclusions and RelevanceThis eDelphi survey study, with consensus among global experts, identified various determinants of AA severity, encompassing not only scalp hair loss but also other outcomes. These findings are expected to facilitate the development of a multicomponent severity tool that endeavors to competently measure various disease impact. The findings are also anticipated to aid in identifying candidates for current and emerging systemic treatments. Future research must incorporate the perspectives of patients and the public to assign weight to the domains recognized in this project as associated with AA severity.

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The associated burden of mental health conditions in alopecia areata: a population‐based study in UK primary care*

Cited by 42 publications

References 28 publications

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Identity and psychological distress in alopecia areata

The Alopecia Areata Severity and Morbidity Index (ASAMI) Study

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