The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the <scp>WHISTLER</scp> cohort

Arabkhazaeli, Ali; Ahmadizar, Fariba; Leusink, Maarten; Arets, Hubertus G.M.; Raaijmakers, J. A. M.; Uiterwaal, Cuno S.P.M.; Ent, Cornelis K. van der; Zee, Anke‐Hilse Maitland‐van der; Vijverberg, Susanne J. H.

doi:10.1111/pai.12824

Cited by 10 publications

(11 citation statements)

References 25 publications

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“…Several studies showed the association between the GRS for allergy and the risk of allergic diseases 28 . However, no study has explored the effect of dietary pattern on AR of children according to the GRS for allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…An appropriate AR therapy might improve children's quality of life and school productivity 11. These results might provide a clue to determine whether the improvement of dietary habits may be helpful to alleviate individual AR symptoms.Several studies showed the association between the GRS for allergy and the risk of allergic diseases 28. However, no study has explored the effect of dietary pattern on AR of children according to the GRS for allergic diseases.…”

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confidence: 99%

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Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending on genetic risk in school children

Lee

Yoon

et al. 2020

Pediatric Allergy Immunology

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Background: The effect of diet on allergic rhinitis (AR), its severity in children, and whether it modifies AR depending on genetic susceptibility are unknown. We investigated the association between dietary patterns and AR in school children and the influence of diet on AR according to a genetic risk score (GRS). Methods: Totally, 435 7-year-old school children were recruited from the Panel Study on Korean Children. We used dietary patterns (vegetable, sugar, and meat) and dietary inflammatory index (DII) as dietary parameters. AR and its severity were defined by questionnaires about treatment in the previous 12 months and the Allergic Rhinitis and its Impact on Asthma (ARIA) guideline, respectively. A GRS was calculated using 6 single nucleotide polymorphisms for allergic diseases.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending on genetic risk in school children

Lee

Yoon

et al. 2020

Pediatric Allergy Immunology

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“…Second, genetic risk was classified based on the number of risk allele homozygotes, which did not fully consider the single effect of each risk allele on the disease and may weaken its role. The genetic risk score (GRS), an emerging method that integrates weak effects of each risk allele and enables valid causal estimates with large numbers of genetic variants, 25 has been widely used in genetic studies of complex diseases 26–28 . In our further research, more genes, and SNPs associated with allergy, as well as GRS, should be included.…”

Section: Discussionmentioning

confidence: 99%

Association of a four‐gene model with allergic diseases: Two‐year follow‐up of a birth cohort study

Yang

Chen

et al. 2020

Immunity Inflam & Disease

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Background Our previous study has developed a four‐gene model involving IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 associated with asthma and atopy in Chinese Han children. However, whether the gene model is associated with allergies in early life has yet to be determined. This study aimed to apply the gene model in a birth cohort to investigate its associations with the development of allergic diseases in Chinese Han toddlers. Methods Five hundred and ninety‐seven children from a birth cohort completing 2‐year follow‐up were included. Epidemiologic information and cord blood were collected. Children were genotyped for the above polymorphisms and divided into high or low genetic risk groups based on the genotypes. Subjects were followed at 6, 12, and 24 months, with information on allergic diseases collected via standard questionnaires and assessed by specialists. Results Two hundred and eighty‐four children were divided into a high‐risk group and 313 into a low‐risk group. Between the two groups, a significant difference was only found in delivery mode among all the subject characteristics (p = .025). After stratification for delivery mode, children at high risk were more likely to develop eczema (relative risk [RR] = 1.46, p = .040) over 2 years of follow‐up compared with those at low risk. No significant associations were found between genetic risk and food allergy, wheezing and allergic rhinitis (p > .05). Conclusion The gene model was significantly associated with the development of eczema in Chinese Han toddlers. Long‐term follow‐up along with functional and replication studies on the gene model are still needed in future.

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“…It integrates weak effects of multiple SNPs and dramatically enhances the predictability of complex diseases using gene polymorphisms [30]. The GRS has been widely applied in genetic studies of common complex diseases, such as diabetes, coronary heart disease, asthma, and others [31][32][33]. The results from the Wheezing Illnesses Study Leidsche Rijn (WHISTLER) cohort illustrated that an adult-derived GRS for allergy predicted the risk of developing allergies during childhood [33].…”

Section: Associations Between the Loose And Stringent Api And Differementioning

confidence: 99%

Association of a 4-Locus Gene Model Including IL13, IL4, FCER1B, and ADRB2 With the Asthma Predictive Index and Atopy in Chinese Han Children

Bai

Wang

et al. 2018

J Investig Allergol Clin Immunol

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The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort

Abstract: Background: Several genetic variants have been associated with the susceptibility to

Cited by 10 publications

References 25 publications

Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending on genetic risk in school children

Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending on genetic risk in school children

Association of a four‐gene model with allergic diseases: Two‐year follow‐up of a birth cohort study

Association of a 4-Locus Gene Model Including IL13, IL4, FCER1B, and ADRB2 With the Asthma Predictive Index and Atopy in Chinese Han Children

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