The association between abnormal serum magnesium levels and prognosis of elderly patients with community-acquired pneumonia

Wang, Si-Qiong; Lu, Dong-xi; Zhang, Jiandong; Wang, Zhiwei; Li, Xiaowei; Ma, Chunming

doi:10.1684/mrh.2022.0493

Cited by 3 publications

(2 citation statements)

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“…35 Hypomagnesemia on admission is also associated with an increased rate of in-hospital mortality among adult patients with community-acquired pneumonia. 36,37 In addition, a recent study showed that hypomagnesemia was a poor prognostic marker of COVID-19. 38 In line with previous findings, our study showed that hypomagnesemia was associated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients

Yang

Lian

Chen

2023

Lupus

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Objective To assess the association of serum magnesium with infection in new-onset systemic lupus erythematosus (SLE) patients. Methods We conducted a single-center retrospective cohort study of new-onset SLE patients from 2012 to 2021. The hospitalized SLE patients were divided into infection and noninfection groups. Logistic regression analysis was conducted to examine the association of hypomagnesemia with infection. Results A total of 476 new-onset SLE patients were included, with 299 cases in the infection group and 177 cases in the noninfection group. The patients were mostly females (81.7%). The average age at diagnosis was 43.7 years. The median duration was 1.0 month. The prevalence of hypomagnesemia (<0.70), normomagnesemia (0.70–1.10), and hypermagnesemia (>1.10) in new-onset SLE patients was 14.3%, 83.4%, and 2.3%, respectively. The prevalence of hypomagnesemia was 18.4% in the infection group and 7.3% in the noninfection group ( p = .001). The baseline value of serum magnesium was 0.819 mmol/L, with values of 0.799 mmol/L in the infection group and 0.854 mmol/L in the noninfection group ( p = .000). The following clinical variables were significantly different between the two groups ( p < .05): age, duration, hospitalization stay, fever, serositis, and SLE Disease Activity Index 2000 (SLEDAI 2K). The laboratory parameters, including hemoglobin, white blood cell count, albumin level, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin, and complement C3 were also significantly different between the two groups ( p < .05). The mortality was 4.4% (21/476), with 20 cases occurring in the infection group. Logistic regression analysis showed that hypomagnesemia was associated with an increased risk of infection ( p = .001) and poor prognosis ( p = .015). Conclusion Hypermagnesemia was rare in new-onset SLE patients. Hypomagnesemia was common and was associated with an increased risk of infection in new-onset SLE patients.

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Section: Discussionmentioning

confidence: 99%

The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients

Yang

Lian

Chen

2023

Lupus

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“…In these individuals, hypomagnesemia at admission was associated with increased short-term mortality ( 71 ). In elderly patients with community-acquired pneumonia, abnormal serum magnesium levels corresponded significantly to in-hospital mortality and 30-day mortality ( 68 , 72 ). However, interventional studies are lacking to confirm the effects of magnesium treatment on pneumonia outcomes.…”

Section: Magnesium and Diseases Causing Cardiac Arrestmentioning

confidence: 99%

The role of magnesium in cardiac arrest

Liu,

Li,

Wang

et al. 2024

Front. Nutr.

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Cardiac arrest is a leading cause of death globally. Only 25.8% of in-hospital and 33.5% of out-of-hospital individuals who achieve spontaneous circulation following cardiac arrest survive to leave the hospital. Respiratory failure and acute coronary syndrome are the two most common etiologies of cardiac arrest. Effort has been made to improve the outcomes of individuals resuscitated from cardiac arrest. Magnesium is an ion that is critical to the function of all cells and organs. It is often overlooked in everyday clinical practice. At present, there have only been a small number of reviews discussing the role of magnesium in cardiac arrest. In this review, for the first time, we provide a comprehensive overview of magnesium research in cardiac arrest focusing on the effects of magnesium on the occurrence and prognosis of cardiac arrest, as well as in the two main diseases causing cardiac arrest, respiratory failure and acute coronary syndrome. The current findings support the view that magnesium disorder is associated with increased risk of cardiac arrest as well as respiratory failure and acute coronary syndrome.

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Causal effect of serum magnesium on the risk of 9 respiratory diseases: a Mendelian randomization study

Zhang,

Li,

Huang

et al. 2023

Preprint

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Objective: Although the association between serum magnesium and respiratory diseases has been explored, the causal effects of serum magnesium on respiratory diseases are largely unknown. Here we performed a Mendelian randomization(MR) analysis to investigate the association between serum magnesium concentrations and risk of 9 respiratory diseases. Methods: Mendelian randomization was conducted using single-nucleotide polymorphisms(SNPs) associated with serum magnesium as instrumental variables.To select SNPs, we used publicly available summary-level data from Genome-wide association studies (GWASs). We used inverse-variance weighted (IVW), weighted median, MR-Egger regression approaches in this analysis.The IVW method was used in the primary analysis to obtain the causal estimates. Results: Genetically predicted serum magnesium was inversely associated with the risk of asthma.The odds ratios in genetically predicted serum magnesium concentrations was 0.229 (95% confidence interval [CI] 0.065-0.806; p=0.022),which was further confirmed by multiple sensitivity analyses. Other diseases such as pulmonary embolism, lobar pneumonia, COVID-19, lung adenocarcinoma, lung squamous cell carcinoma, bronchiectasis, tuberculosis and interstitial lung disease did not yield statistically significant results. Conclusions: High genetically predicted serum magnesium was causally associated with a decreased risk of asthma and suggested that serum magnesium concentrations may be crucial to prevent the onset of asthma.

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The association between abnormal serum magnesium levels and prognosis of elderly patients with community-acquired pneumonia

Cited by 3 publications

References 0 publications

The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients

The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients

The role of magnesium in cardiac arrest

Causal effect of serum magnesium on the risk of 9 respiratory diseases: a Mendelian randomization study

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