The association between adiponectin and diabetes in the Korean population

Yoon, Soo Jin; Lee, Hong Soo; Lee, Sang−Wha; Yun, Ji Eun; Kim, Sang Yon; Cho, Eo Rin; Lee, Sun Ju; Jee, Eun Jung; Lee, Hee Yeon; Park, Jungyong; Kim, Hyun Sook; Jee, Sun Ha

doi:10.1016/j.metabol.2008.01.031

Cited by 38 publications

(32 citation statements)

References 17 publications

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“…Fasting serum insulin was determined by chemiluminescence (RIA Kit; Daiichi, Japan), and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index, calculated with the following formula: HOMA-IR fasting insulin ( U/mL) fasting plasma glucose (mmol/L)/22.5. Plasma adiponectin was measured by the enzyme linked immunosorbent assay (ELISA; Mesdia, Seoul, Korea) 22) .…”

Section: Biochemical Parametersmentioning

confidence: 99%

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Park

Kang

Yoo

et al. 2012

J Atheroscler Thromb

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Aim: Serum -glutamyltransferase (GGT) is used as a marker of hepatic dysfunction. Recently, several studies reported that GGT is significantly associated with cardiovascular mortality and atherosclerosis. Adiponectin is known to play an important role in the development of atherosclerosis, but its physiologic role has yet to be fully determined. In this study, we investigated the relationships among serum GGT, adiponectin and arterial stiffness. Methods: Of 4236 subjects recruited from 17 different medical centers in Seoul, Korea, 2846 subjects were enrolled in our study. The parameters of metabolic syndrome (MetS) were assessed in these subjects, and their plasma adiponectin levels and pulse wave velocity (PWV) were measured along with anthropometric and biochemical profiles, including GGT. Results: The subjects were stratified into 3 groups according to GGT values. PWV values gradually increased and the adiponectin level decreased with GGT tertiles. Aortic PWV showed a significant correlation with age, SBP, FPG, but there was no correlation among aortic PWV, GGT and adiponectin. Peripheral PWV demonstrated a significant correlation with age, SBP, DBP, BMI, WC, FPG and GGT, but there was no correlation between peripheral PWV and adiponectin. In multiple logistic regression analysis after adjusting for risk factors, GGT was a significant contributor to increased peripheral PWV. Conclusions: These findings indicate that serum GGT is independently associated with increased arterial stiffness, but there was no correlation between adiponectin and arterial stiffness in both males and females. J Atheroscler Thromb, 2012; 19:90-97.

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Section: Biochemical Parametersmentioning

confidence: 99%

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Park

Kang

Yoo

et al. 2012

J Atheroscler Thromb

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“…Recruitment of these volunteer subjects only took place after their informed consent had been obtained. Participating hospitals are listed in the appendix [16]. The analysis excluded subjects with missing information on waist circumference (WC), body mass index (BMI), or adiponectin levels, and those who had a history of cancer, cardiovascular disease, stroke, diabetes, or hypertension (n = 565).…”

Section: Study Subjectsmentioning

confidence: 99%

Serum Adiponectin Is Associated with Smoking Status in Healthy Korean Men

et al. 2009

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Abstract. Objective: To measure the association between smoking and serum adiponectin, taking into consideration insulin resistance and obesity. Material and Methods: The cross-sectional study was carried out in Seoul, Korea in 2006. Waist circumference (WC), body mass index (BMI), and serum adiponectin were measured in 2,500 healthy Korean men. Multiple linear regression models were used to assess the association of smoking status with serum adiponectin level. WC, BMI, and homeostasis model assessment (HOMA) were classified into two groups according to median values. Results: The mean adiponectin concentrations were 6.6 μg/ml and 7.3 μg/ml in current smokers and non-smokers. After adjusting for age, BMI, and alcohol consumption, mean log adiponectin levels decreased by 0.064 μg/ml in current smokers compared with non-smokers (P = 0.0190). Mean log adiponectin levels also decreased by 0.030 and 0.095 μg/ml in moderate and heavy smokers compared to non-smokers. The relationship between adiponectin and smoking was similar between the high and low insulin resistance, BMI, and WC groups. Conclusions: These results suggest that serum adiponectin levels are associated with smoking status. These data also support that lower serum adiponectin concentrations in smokers may not be dependent on insulin resistance status or obesity. [7] showed that plasma adiponectin concentrations were reduced among individuals with obesity, diabetes mellitus, or coronary heart disease [7,8], implying that adiponectin plays a role in these conditions.Many studies have reported on hypoadiponectinemia in smokers [9][10][11][12][13]. However, the underlying mechanisms of this relationship are not yet fully understood. Because the prevalence of insulin resistance may also be increased in smokers [14,15], it is not clear whether hypoadiponectinemia in these individuals is due to smoking, or to the coexistence of insulin resistance. However, relevant literature on the relationship between serum adiponectin and smoking status independent of insulin resistance is sparse. Thus, the purpose of this study was to measure the association between smoking and adiponectin, taking into consideration the effects of insulin resistance and obesity. We hypothesized that adiponectin in smokers is associated with smoking status regardless of insulin resistance and obesity.

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“…The study population consisted of 6,551 subjects who were recruited only after informed consent was obtained (Yoon et al, 2008). A total of 3,390 subjects (1,940 males and 1,450 females) underwent PWV measurements.…”

Section: Study Populationmentioning

confidence: 99%

Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

Sull

Koh

Cho

et al. 2017

BSL

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Measuring the pulse wave velocity (PWV) is a non-invasive method for evaluating the stiffness of the vessel wall. While previous studies investigated the association of uric acid level with arterial stiffness, most did not consider smoking status and obesity as covariates. The objective of this study was to investigate the relationship between uric acid levels and arterial stiffness, considering smoking status and obesity. We studied 3390 subjects (1940 males and 1450 females). Abnormal PWV was also defined as the highest quartile of values in the subjects. Data were analyzed using Pearson correlation, t-test, and multiple regression analysis. Approximately 41.9% of men and 3.7% of women were current smokers. Prevalence of hypertension was 11.4% in men and 7.0% in women. In women, hyperuricemia was associated with abnormal PWV (OR 1.58; 95% CI 1.03~2.43). Hyperuricemia was also associated with abnormal PWV (OR 2.37; 95% CI 1.01~5.59) in non-or light male smokers with normal blood pressure. This study suggests that uric acid is associated with arterial stiffness in women and non-smoking men.

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The association between adiponectin and diabetes in the Korean population

Cited by 38 publications

References 17 publications

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Serum Adiponectin Is Associated with Smoking Status in Healthy Korean Men

Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

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The association between adiponectin and diabetes in the Korean population

Cited by 38 publications

References 17 publications

Association between &gamma;-Glutamyltransferase, Adiponectin and Arterial Stiffness

Association between &gamma;-Glutamyltransferase, Adiponectin and Arterial Stiffness

Serum Adiponectin Is Associated with Smoking Status in Healthy Korean Men

Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

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Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness