The association between apelin polymorphisms and hypertension in China: A meta-analysis

Abstract

Introduction:Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.Materials and methods:Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model.Results:The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82–1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89–1.14). For males, the pooled odds ratio of the frequency of G allele was 0.69 (95% confidence interval: 0.46–1.03). As for rs56204867, the overall pooled odds ratio of the frequency of G allele was 1.09 (95% confidence interval: 0.86–1.37). In females, the pooled odds ratio of the frequencies of the G allele was 1.05 (95% confidence interval: 0.86–1.29). In male participants, the frequency of G allele did not show significant correlation with hypertension (pooled odds ratio=1.21 95% confidence interval: 0.81–1.79).Conclusion:This meta-analysis revealed that there was no correlation between apelin polymorphisms, rs3761581 and rs56204867, and the prevalence of hypertension.

The APLNR gene polymorphism rs7119375 is associated with an increased risk of development of essential hypertension in the Chinese population

“…Our results suggest an important clinical implication of rs7119375 because it is located in the promoter region of the APLNR gene [ 23 ] and may regulate gene expression. [ 7 ] Although the included studies in our meta-analysis did not measure circulating apelin levels or expressing APLNR levels, a meta-analysis showed that circulating apelin levels were significantly lower in patients with CAD. [ 26 ] The APLNR gene localizes in chromosome 11q12.1 [ 27 ] and encodes for the G protein-coupled receptor for which apelin is an endogenous ligand.…”

“…Recently, a meta-analysis has found no significant correlations between SNPs in the apelin gene and the risk of development of essential HT in the Chinese population. [ 7 ] To the best of our knowledge, however, the associations between SNPs in the APLNR gene and the risk of development of essential HT have not been investigated. Therefore, we conducted this meta-analysis to determine the association between SNPs in the APLNR gene and the risk of development of essential HT.…”