The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third National Health and Nutrition Examination Survey

Wang, Shudan; Pillinger, Michael H.; Krasnokutsky, Svetlana; Barbour, Kamil E.

doi:10.1016/j.joca.2019.05.013

Cited by 21 publications

(15 citation statements)

References 34 publications

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“…A positive dose–response relationship between TC levels and the risk of KOA in clinical patients was demonstrated in a Chinese cohort [ 29 ]. In contrast, in other studies of the association between metabolic syndrome and OA, hyperlipidemia was not a risk factor for OA after adjusting for BMI and other factors [ 30 ]. We know that in the past, OA is generally considered to be a degenerative disease.…”

Section: Resultscontrasting

confidence: 57%

Osteoarthritis or arthritis? Toward understanding of primary Sjögren’s syndrome patients with arthralgia

Gao

et al. 2023

J Orthop Surg Res

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Objective To identify primary Sjögren’s syndrome (pSS) patients with arthralgia at risk for osteoarthritis (OA) or arthritis. Methods This study included 368 pSS patients admitted to a mono-centric from March 2010 to December 2020. Patients were divided into groups according to whether complicated with OA or arthritis. Data were analyzed to determine the differences in demographical characteristics, symptoms, and laboratory examination. Results The involvement of the OA joints was predominately knee and spine sites (including cervical and lumbar spine degeneration). When diagnosing arthritis, it was mainly peripheral symmetric polyarthritis, the most affected sites were the interphalangeal and metacarpophalangeal joints. There were significant differences in age, disease duration, uric acid (UA), and total cholesterol (TC) between pSS-OA and pSS-nOA patients (P < 0.050). Logistic regression analysis showed that age (OR = 1.965; P = 0.009) and joint pain (OR = 3.382; P < 0.001) were dangerous factors associated with OA. Interestingly, although the level of UA, TC, and triglycerides (TG) was shown to be positive with OA, there was no statistical significance after the OR was computed in the four-cell table. In pSS-arthritis, EULAR Sjögren's syndrome disease activity index (ESSDAI) (P = 0.011), the frequency of joint pain (P < 0.001), and muscular involvement (P = 0.037) were higher than non-arthritis group. In pSS patients only presenting with joint pain, arthritis patients had higher ESSDAI and system involvements, but lower UA and TG levels compared with OA group (P < 0.050). Conclusion In pSS patients with arthralgia, OA accounted for the majority. pSS patients with advanced age and more pronounced metabolic characteristics, such as elevated blood lipids and uric acid, was a key factor in groups at risk for OA. However, arthritis patients had higher rates of dry mouth and eye, higher disease activity, antibodies positive, and more organs damage. In the future, it may be necessary to be more cautious in the diagnosis of joint manifestations in pSS patients in order to make the appropriate treatments.

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Section: Resultscontrasting

confidence: 57%

Osteoarthritis or arthritis? Toward understanding of primary Sjögren’s syndrome patients with arthralgia

Gao

et al. 2023

J Orthop Surg Res

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“…[ 3 ] As for HU, four studies suggested a positive association with OA. [ 2 , 28 – 30 ] In contrast, only one studies reported that there was no association between gout and radiographic OA. [ 31 ]…”

Section: Discussionmentioning

confidence: 99%

Association between hyperuricemia, gout, urate lowering therapy, and osteoarthritis

et al. 2020

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“…The old age of the study population also limits conclusions with regard to the applicability of these results to other age categories, it may be limited to elderly females only, possible reasons being age-related changes in hand tissues and fluctuations in hydration status. The cut-off of SUA <372 μmol/L calculated in the current study may also vary between populations, depending on a number of other factors including obesity [14].…”

Section: Discussionmentioning

confidence: 99%

“…In rheumatology, hyperuricemia and symptomatic gout appear to be a part of a spectrum, with crystal deposition and synovitis in joints sometimes evident even in the absence of clinical gout [11–13]. A recent NHANES study also indicates that hyperuricemia is associated with symptomatic knee osteoarthritis, most apparent in non-obese patients [14].…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study

et al. 2019

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Background The debate whether "asymptomatic hyperuricemia" should be treated is still ongoing. The objective of this cross-sectional study was to analyze whether hyperuricema in the elderly is associated with joint pain. Methods and findings Participants in the population-based AGES-Reykjavik Study (males 2195, females 2975, mean age 76(6)) answered standardized questions about joint pain. In addition they recorded intermittent hand joint pain by marking a diagram of the hand. In males, no association was found between hyperuricemia and pain. Females however, showed a positive association between hyperuricemia and joint pain at many sites. After adjustment for age, BMI and hand osteoarthritis however, only intermittent hand joint pain (OR 1.30(1.07–1.58), p = 0.008) and intermittent pain in ≥10 hand joints (OR 1.75(1.32–2.31), p<0.001) remained significant. The best model for describing the relationship between serum uric acid levels (SUA) and intermittent hand joint pain in ≥10 joints was non-linear with a cut-off at 372 μmol/L. The attributable surplus number of symptomatic females with SUA ≥372 μmol/L was approximately 2.0% of the study population for those reporting pain in ≥10 hand joints. Next after having severe hand osteoarthritis, SUA ≥372 was an independent predictive factor of intermittent pain in ≥10 hand joints. Intermittent hand joint pain was also an independent risk factor for worse general health description. Conclusion Results from this population based study indicate that hyperuricemia in elderly females may be a rather frequent cause of intermittent hand joint pain, often in many joints. The most likely explanation relates to low-grade urate crystal induced inflammation. Our data do not allow for assessment of the severity of symptoms or whether they merit specific treatment, but intermittent hand joint pain was an independent predictor of worse general health. These findings may be an important contribution to the debate on whether hyperuricemia should be treated.

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The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third National Health and Nutrition Examination Survey

Cited by 21 publications

References 34 publications

Osteoarthritis or arthritis? Toward understanding of primary Sjögren’s syndrome patients with arthralgia

Osteoarthritis or arthritis? Toward understanding of primary Sjögren’s syndrome patients with arthralgia

Association between hyperuricemia, gout, urate lowering therapy, and osteoarthritis

Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study

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