The association between blood pressure and lipid levels in Europe

Borghi, Claudio; Rodríguez‐Artalejo, Fernando; Backer, Guy De; Dallongeville, Jean; Medina, Jesús; Güallar, Eliseo; Perk, Joep; Banegas, José R.; Tubach, Florence; Roy, Carine; Halcox, Julian

doi:10.1097/hjh.0000000000001078

Cited by 24 publications

(17 citation statements)

References 44 publications

(56 reference statements)

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“…In hypertensive patients, SBP had statistically significant correlation with serum LDL-C and TG levels which tended to rise as the duration of hypertension advances. Plethora of studies such as a study conducted in Europe, 55 another study carried out in India, 12 in Nigeria, 27 and a study conducted in Ethiopia 24 are in trajectory with this study. Hypertension and lipid abnormalities are well known to frequently coexist and synergize to be risk factors for CVD.…”

Section: Discussionmentioning

confidence: 76%

Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

et al. 2018

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Introduction:Hypertension and dyslipidemia are the two coexisting and synergizing major risk factors for cardiovascular diseases. The cellular constituents of blood affect the volume and viscosity of blood, thus playing a key role in regulating blood pressure. Overweight and obesity are key determinants of adverse metabolic changes including an increase in blood pressure. The aim of this study was to evaluate lipid profiles and hematological parameters in hypertensive patients at Debre Markos Referral Hospital, Northwest Ethiopia.Methods:Laboratory-based cross-sectional study was conducted in 100 eligible hypertensive patients at the hospital. The required amount of blood was withdrawn from the patients by healthcare professionals for immediate automated laboratory analyses. Data were collected on socio-demographic factors, anthropometric measurements, blood pressure, lipid profiles, and hematological parameters.Result:The mean serum levels of triglyceride, total cholesterol, and low-density lipoprotein were significantly higher than their respective cut-off values in the hypertensive patients. Besides, 54%, 52%, 35%, and 11% of the hypertensive patients had abnormal low-density lipoprotein, total cholesterol, triglyceride, and high-density lipoprotein levels, respectively. Higher levels of low-density lipoprotein, hemoglobin, and red blood cell count were observed in the hypertensive patients whose blood pressure had been poorly controlled than the controlled ones (p < 0.05). Waist circumference had a significant positive association with the serum levels of total cholesterol and white blood cell count (p < 0.05).Conclusion:Hypertensive patients had a high prevalence of lipid profile abnormalities and poorly controlled blood pressure which synergize in accelerating other cardiovascular diseases. Some hematological parameters such as red blood cell count are also increased as do the severity of hypertension.

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Section: Discussionmentioning

confidence: 76%

Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

et al. 2018

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“…Based on the evidence, we evaluated BMI [ 4 ], smoking status (non-smoker, ex-smoker, current smoker) [ 4 , 10 ], renal function [ 15 ], LDL-c [ 16 ], parental HTN (yes/no) [ 4 , 5 ], and diabetes at baseline (yes/no) [ 17 ] as potential risk factors. BMI was classified into two groups (<23 and ≥23 kg/m 2 ) and reduced renal function was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m 2 [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Diet-Related Risk Factors for Incident Hypertension During an 11-Year Follow-Up: The Korean Genome Epidemiology Study

Lee

Park

2018

Nutrients

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Using long-term follow-up cohort data from the Korean Genome Epidemiology Study, we assessed the dietary risk factors for incident hypertension (HTN). In total, 6792 subjects (3300 males and 3492 females) aged 40–69 years were included in the study. Physician-diagnosed HTN self-reported by the participants was used as the outcome. Daily intake of 20 food groups was assessed while using a dish-based semi-quantitative food-frequency questionnaire. After controlling for known risk factors, the food groups that were most closely associated with HTN were identified by forward stepwise selection while using the Cox proportional hazards model. The median follow-up period was 11.5 years (interquartile range, 6.0–11.7 years) and the incidence of HTN was 20 per 1000 person-years. Older age, obesity, lower education level, high alcohol intake, and having at least one parent with HTN were associated with the risk for HTN. In addition, a high intake of salted seafood and a low intake of eggs and meat were independently associated with the incidence of HTN after controlling for the known risk factors. Those in the top quartile of salted seafood intake had a 28% greater risk for incident HTN than those in the bottom quartile. The population-attributable fraction of three dietary factors accounted for 29.0% of the incidence of HTN. A high intake of salted seafood and a low intake of eggs and meat were associated with a greater risk for HTN.

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“…Dyslipidemia are recognized as a strong predictor of cardiovascular disease and several studies have suggested a positive correlation between dyslipidemia and hypertension [ 10 , 11 ]. Leptin, an adipocytokine produced by adipose tissue, is associated with dyslipidemia [ 12 ], and recent study has demonstrated that leptin contributes to hypertension through upregulation of central renin–angiotensin system and proinflammatory cytokines [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of the hypertension-related single nucleotide polymorphism rs11191548 with high-density lipoprotein cholesterol and leptin in Chinese children

Gao

Zhao

et al. 2018

BMC Med Genet

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BackgroundThe genome-wide association study has founded hypertension-related single nucleotide polymorphism (SNP) rs11191548 near CYP17A1 encoding a key enzyme involved in steroid metabolism, but the molecular mechanisms are not understood and the associations of the SNP with hypertension-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNP and two hypertension-related traits, lipids and leptin.MethodsWe genotyped the SNP in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. A total of 3503 children participated in the study.ResultsThe SNP rs11191548 was significantly associated with high-density lipoprotein cholesterol (HDL) (P = 0.014 and 0.028, respectively) and leptin (P = 0.011 and 0.026, respectively) under an additive model after adjustment for age, gender, and systolic blood pressure (SBP) or diastolic blood pressure (DBP). There was a statistically significant association of rs11191548 with high leptin after adjustment for age, gender, and SBP or DBP. The P-values remain significant after correction for multiple testing.ConclusionsWe demonstrate for the first time that the SNP rs11191548 near CYP17A1 is associated with HDL and leptin in Chinese children. These novel findings provide important evidence that HDL and leptin maybe possibly mediate the process of CYP17A1 involved in hypertension.Electronic supplementary materialThe online version of this article (10.1186/s12881-018-0523-y) contains supplementary material, which is available to authorized users.

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The association between blood pressure and lipid levels in Europe

Cited by 24 publications

References 44 publications

Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

Diet-Related Risk Factors for Incident Hypertension During an 11-Year Follow-Up: The Korean Genome Epidemiology Study

Associations of the hypertension-related single nucleotide polymorphism rs11191548 with high-density lipoprotein cholesterol and leptin in Chinese children

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