The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

Nyabera, Akwe; Lakhdar, Sofia; Li, Matthew; Trandafirescu, Theo; Tall, Sakina Ouedraogo

doi:10.7759/cureus.11183

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…In all the groups greater percentage comprised of the overweight and obese category. Few studies highlight age as an important factor for Covid related complication and exhibit BMI as a less important factor 15 , and this finding was also consistent with our data as greater proportion of patients in our study requiring advanced management were of higher age group. The number of patients in our study, with severe symptoms, however was high for the overweight and obese group and greater proportion of these patients required active management in the form of oxygen therapy, injectables, as well as oral medication, so BMI was an important predictor of diseases severity.…”

Section: Resultssupporting

confidence: 92%

Impact of BMI on Covid-19 Clinical Features and its Management: A Cross Sectional Study

Anwar¹,

Masud²,

Rafique³

et al. 2021

PJMHS

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The whole world is suffering from COVID-19 pandemic. This disease has halted life and has a negative impact on physical and mental health of all individuals. Objectives: To identify impact of BMI on Covid-19 clinical features and its management in terms of relationship among patients at government hospitals, Pakistan. Study Design: Cross-sectional study. Methodology: This study enrolled 206 patients having both genders and was carried at Life Diabetes Centre, Gujrat and CMH Kharian Medical College (CKMC), over a period of 3 months, Kharian-Pakistan following ethical review committee’s (ERC) approval. Statistical analysis: Data was analyzed by SPSS software, version 17. Parameters like age, gender and treatment taken were presented as frequency. Chi square was applied to see the correlation with p-value <0.05 as significant. Results: Total 206 patients were randomly selected, 89 male and 117 females. Among 206, patients (n=133) showed symptoms while rest of the patients (73) remained asymptomatic. There was no association of BMI with COVID-19 symptoms having P-value greater than 0.05. There was an association of BMI with gender as P-value (0.000*). There was an association of BMI with age having P-value (0.000*). Conclusion: From present study, we concluded that there was a correlation between BMI and individuals with higher BMI as they developed more serious symptoms and required active management strategies in comparison to individuals who were either underweight or normal weight. Key Words: Covid-19, BMI, Treatment and Gender.

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Section: Resultssupporting

confidence: 92%

Impact of BMI on Covid-19 Clinical Features and its Management: A Cross Sectional Study

Anwar¹,

Masud²,

Rafique³

et al. 2021

PJMHS

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show abstract

“…Likewise, although we noticed that BMI and obesity prevalence tended to be higher in non-survivors than survivors, we found no significant effects on the COVID-19 case fatality rate. Concurring with our findings, several studies have reported that BMI or obesity are not necessarily independent predictors of in-hospital mortality in COVID-19 [ 41 , 42 , 43 ]. We can explain these controversial findings since, at the time of hospitalization, all patients enrolled in this study had developed the most severe form of COVID-19, including respiratory distress and pneumonia.…”

Section: Discussionsupporting

confidence: 88%

The Combined Use of Cytokine Serum Values with Laboratory Parameters Improves Mortality Prediction of COVID-19 Patients: The Interleukin-15-to-Albumin Ratio

et al. 2021

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Laboratory parameters display limited accuracy in predicting mortality in coronavirus disease 2019 (COVID-19) patients, as with serum albumin. Emerging evidence suggests that cytokine serum values may enhance the predictive capacity of albumin, especially interleukin (IL)-15. We thus investigated whether the use of the IL-15-to-albumin ratio enables improving mortality prediction at hospital admission in a large group of COVID-19 patients. In this prospective cross-sectional study, we enrolled and followed up three hundred and seventy-eight patients with a COVID-19 diagnosis until hospital discharge or death. Two hundred and fifty-five patients survived, whereas one hundred and twenty-three died. Student’s T-test revealed that non-survivors had a significant two-fold increase in the IL-15-to-albumin ratio compared to survivors (167.3 ± 63.8 versus 74.2 ± 28.5), a difference that was more evident than that found for IL-15 or albumin separately. Likewise, mortality prediction considerably improved when using the IL-15-to-albumin ratio with a cut-off point > 105.4, exhibiting an area under the receiver operating characteristic curve of 0.841 (95% Confidence Interval, 0.725–0.922, p < 0.001). As we outlined here, this is the first study showing that combining IL-15 serum values with albumin improves mortality prediction in COVID-19 patients.

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“…However, in our study, BMI was not found to be a risk factor for in-hospital mortality. A similar finding showing lack of association between BMI and COVID-19 mortality was obtained in other US studies [31]. Our multivariate logistic regression showed that only mechanical ventilation was significantly associated with mortality.…”

Section: Cell Countssupporting

confidence: 92%

Effects of Race on the Outcome of COVID-19 in Hospitalized Patients

Abate¹,

Kapoor²,

Charbek³

et al. 2021

J Infect Dis Epidemiol

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Background and aims:Recent reports indicate that African Americans have higher mortality rates from SARS-CoV-2 coronavirus disease 19 (COVID-19) compared to Caucasians, with more marked differences in the Midwest region of the US. This study was performed to study differences in COVID-19 related mortality and hospital length of stay (LOS) between African Americans and Caucasians in Midwest setting, and identify factors associated with mortality and LOS.Methods: Data were collected from the electronic health records (EHR) of patients admitted to hospitals in Midwest region of the US. EHR of 471 COVID-19 patients were reviewed.Results: Approximately 63% were African Americans and 34% Caucasians. One hundred sixteen variables were tested. There was no significant difference in hospital mortality between African Americans and Caucasians (OR 1, 95% CI 0.48-1.94). Older age, Chronic kidney disease, mental status change, mechanical ventilation, vasopressor support, high neutrophil count, elevated AST and ALT, high lung involvement severity score and elevated CRP were associated with mortality in a univariate analysis (P < 0.05). Multivariable modelling indicated that mechanical ventilation was the only factor that predicted mortality (OR 6, 95% CI: 2.94-12.48). The LOS did not differ in African Americans and Caucasians. The use of oxygen via high flow nasal cannula (Survival Estimate 1.6, 95% CI: 1.20-2.26), low estimated glomerular filtration rate (Survival Estimate 1.4, 95% CI: 1.05-1.82) and mechanical ventilation (Survival Estimate 3.5, 95% CI: 2.72-4.37) were predictors of LOS. Conclusion:This study performed in Midwest setting in the US showed that race did not affect in-hospital mortality and LOS. Our analysis demonstrated new predictors of LOS.

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The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

Cited by 12 publications

References 22 publications

Impact of BMI on Covid-19 Clinical Features and its Management: A Cross Sectional Study

Impact of BMI on Covid-19 Clinical Features and its Management: A Cross Sectional Study

The Combined Use of Cytokine Serum Values with Laboratory Parameters Improves Mortality Prediction of COVID-19 Patients: The Interleukin-15-to-Albumin Ratio

Effects of Race on the Outcome of COVID-19 in Hospitalized Patients

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