The association between body lead levels and childhood rickets

Zhang, Yongfang; Xu, Jiang-Wei; Yao, Yang; Huang, Xueqin; Yu, Xinqiao

doi:10.1097/md.0000000000014680

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…In the past several decades, besides low serum levels of Ca and P that have been proposed as a screening test in patients who have clinical symptoms suggestive of osteomalacia (271), elevated concentrations of several other elements have been observed in different biological samples of osteomalacia patients, such as Al, Fe, Cd, and Sr in bone or serum and Pb in blood or hair (childhood rickets) (272)(273)(274)(275). In contrast, Fe deficiency was reported in autosomal dominant hypophosphatemic rickets, a rare form of rickets caused by mutations in the fibroblast growth factor 23 (FGF23) gene, implying that monitoring the Fe status is helpful for diagnosis, prognosis, and treatment of this genetic disease (276).…”

Section: Osteoporosis and Osteomalaciamentioning

confidence: 99%

Micronutrients and Metabolic Diseases

An,

Yang,

et al. 2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Osteoporosis and Osteomalaciamentioning

confidence: 99%

Micronutrients and Metabolic Diseases

An,

Yang,

et al. 2024

Frontiers Research Topics

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“…In the past several decades, besides low serum levels of Ca and P that have been proposed as a screening test in patients who have clinical symptoms suggestive of osteomalacia ( 271 ), elevated concentrations of several other elements have been observed in different biological samples of osteomalacia patients, such as Al, Fe, Cd, and Sr in bone or serum and Pb in blood or hair (childhood rickets) ( 272 – 275 ). In contrast, Fe deficiency was reported in autosomal dominant hypophosphatemic rickets, a rare form of rickets caused by mutations in the fibroblast growth factor 23 (FGF23) gene, implying that monitoring the Fe status is helpful for diagnosis, prognosis, and treatment of this genetic disease ( 276 ).…”

Section: Recent Progress In Ionomics Of Metabolic Diseasesmentioning

confidence: 99%

Recent advances in the application of ionomics in metabolic diseases

et al. 2023

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Trace elements and minerals play a significant role in human health and diseases. In recent years, ionomics has been rapidly and widely applied to explore the distribution, regulation, and crosstalk of different elements in various physiological and pathological processes. On the basis of multi-elemental analytical techniques and bioinformatics methods, it is possible to elucidate the relationship between the metabolism and homeostasis of diverse elements and common diseases. The current review aims to provide an overview of recent advances in the application of ionomics in metabolic disease research. We mainly focuses on the studies about ionomic or multi-elemental profiling of different biological samples for several major types of metabolic diseases, such as diabetes mellitus, obesity, and metabolic syndrome, which reveal distinct and dynamic patterns of ion contents and their potential benefits in the detection and prognosis of these illnesses. Accumulation of copper, selenium, and environmental toxic metals as well as deficiency of zinc and magnesium appear to be the most significant risk factors for the majority of metabolic diseases, suggesting that imbalance of these elements may be involved in the pathogenesis of these diseases. Moreover, each type of metabolic diseases has shown a relatively unique distribution of ions in biofluids and hair/nails from patients, which might serve as potential indicators for the respective disease. Overall, ionomics not only improves our understanding of the association between elemental dyshomeostasis and the development of metabolic disease but also assists in the identification of new potential diagnostic and prognostic markers in translational medicine.

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“…The association between rickets in children and lead exposure has long been recognised (Caffey 1938), and has also been identified in children from across the Roman Empire (Moore et al 2021), but the relationship is complex. Both calcium and lead are divalent cations with similar metabolic characteristics, but as lead is a larger more active ion it is preferentially metabolised over calcium and 1, 25-dihydroxy-vitamin D, leading to vitamin D deficiency (Nwobi et al 2019;Zhang et al 2019). Lead absorbed in the gut through contaminated food can be as high as 45% in fasting conditions, and up to 53% in malnourished children (Gidlow, 2015).…”

Section: Lead Exposurementioning

confidence: 99%

Youth Mobility, Migration, and Health Before and After the Black Death

Lewis

Montgomery²

2022

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Migration is driven by the young but despite this, few isotope studies focus on adolescent migrants or the intricatenature of their movement. Using a multi-analytical approach, the authors explore this mobility and the impact of urban living on the diet and health of adolescents from the pre-and post-Black Death periods of Northern England. Isotope analysis (carbon, nitrogen, oxygen, and strontium) and lead concentrations were measured in 63 adolescents (10–25 years) from three sites in medieval York and from the nearby small town of Barton-upon-Humber. York was an important center in medieval England, acting as a magnet for adolescents seeking a new life and independence; Barton was seen as less attractive and harder to reach. In the pre-Black Death sample, 33% of adolescents (n=8/24; including five males and two females) were identified as possible migrants by their oxygen and strontium values. Following the Black Death only 5% (n=2/39) of adolescents, both from Barton, appeared to be migrants from elsewhere in Britain, indicating the pattern changed from individuals traveling long distances to more local, isotopically “invisible” movement. The non-locals appear to have been well integrated, sharing the same diet as the locals, but there was some evidence for different burial practices. Working in medieval York posed significant health risks for all of the young inhabitants, with lead concentrations at pathological levels, and possibly linked to anemia and vitamin D deficiency. This research highlights the importance of combining historical, archaeological, paleopathological, and chemical data to understand complex life histories of adolescents in the past. La migración es impulsada por los jóvenes. No obstante, pocos estudios de isótopos se centran en los adolescentes migrantes o en la naturaleza de sus movimientos. Utilizando un enfoque multi-analítico, las autoras exploran esta movilidad y el impacto de la vida urbana en la dieta y la salud de los adolescentes de los períodos anterior y posterior a la peste negra en el norte de Inglaterra. El análisis de isótopos (carbono, nitrógeno, oxígeno, y estroncio) y las concentraciones de plomo se midieron en 63 adolescentes (10–25 años) de tres sitios en la York medieval, y de la pequeña ciudad cercana de Barton-upon-Humber. York era un centro importante en la Inglaterra medieval, actuando como un imán para los adolescentes que buscaban una nueva vida e independencia. Barton era visto como menos atractivo y más difícil de alcanzar. En la muestra previa a la peste negra, el 33% de los adolescentes (n=8/24) fueron identificados como posibles migrantes por sus valores de oxígeno y estroncio (cinco masculinos y dos femeninos). Después de la peste negra, solo el 5% (n = 2/39) de los adolescentes, ambos de Barton, parecían ser migrantes de otras partes de Gran Bretaña, lo que indica que el patrón cambió de individuos que viajaban largas distancias a un movimiento isotópicamente “invisible” más local. Los no locales parecen haber estado bien integrados, compartiendo la misma dieta con la población local, pero hubo evidencia de diferentes prácticas de entierro. Trabajar en York medieval planteaba riesgos significativos para la salud de todos los habitantes jóvenes, con concentraciones patológicas de plomo posiblemente relacionadas con anemia y deficiencia de vitamina D. Esta investigación destaca la importancia de combinar datos históricos, arqueológicos, paleopatológicos, y químicos para comprender las complejas historias de vida de los adolescentes en el pasado.

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The association between body lead levels and childhood rickets

Abstract: Supplemental Digital Content is available in the text

Cited by 5 publications

References 21 publications

Micronutrients and Metabolic Diseases

Micronutrients and Metabolic Diseases

Recent advances in the application of ionomics in metabolic diseases

Youth Mobility, Migration, and Health Before and After the Black Death

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