The association between body mass index, waist circumference, waist–hip ratio and cognitive disorder in older adults

Liu, Zhizhen; Yang, Hongqing; Chen, Shiya; Cai, Jing; Zi-jie, Huang

doi:10.1093/pubmed/fdy121

Cited by 54 publications

(45 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another finding of the present study is that abdominal obesity is associated with an increased risk of cognitive impairment. Liu et al showed that central obesity (defined by WHR <0.9 for males and <0.85 for females) was significantly associated with a higher risk of cognitive impairment in 491 subjects aged 70 years and older (OR=1.980, 95% CI=1.129–3.472) 20. Luchsinger et al revealed that a higher WHR was related to a higher risk of late-onset Alzheimer’s disease (HR of the fourth quartile compared to the first=2.5, 95% CI=1.3–4.7) after adjustment for conventional risk factors 21.…”

Section: Discussionmentioning

confidence: 99%

<p>Associations between obesity and cognitive impairment in the Chinese elderly: an observational study</p>

Hou

Guan

et al. 2019

CIA

110

View full text Add to dashboard Cite

Purpose The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly. Patients and methods Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May 2017. Mini-Mental State Examination scale was used to assess the cognitive function. Body mass index (BMI) and waist–hip ratio were used to classify obesity. Student’s t -test, Mann–Whitney U -test, or chi-squared test was used to compare the data between participants with normal cognition and participants with cognitive impairment as appropriate. Univariate logistic regression models and multivariate logistic regression models were performed to explore the relationship between BMI or abdominal obesity and cognitive impairment. Results A total of 1,100 patients including 568 men and 532 women aged 60–98 years (median age 79 years) were enrolled. After adjusting for age, gender, smoking, drinking, education level, hypercholesterolemia, hypertension, and diabetes, overweight was significantly associated with a decreased risk of cognitive impairment (OR=0.458, 95% CI=0.298–0.703, P <0.001). After adjustment for age, education level, hypercholesterolemia, hypertension, and diabetes, abdominal obesity remained significantly associated with an increased risk of cognitive impairment (OR=1.532, 95% CI=1.037–2.263, P =0.032). Conclusion Overweight is associated with a decreased risk of cognitive impairment in the Chinese elderly, while abdominal obesity is associated with an increased risk of cognitive impairment independent of conventional sociodemographic, lifestyle, and health-related comorbid factors.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Associations between obesity and cognitive impairment in the Chinese elderly: an observational study</p>

Hou

Guan

et al. 2019

CIA

110

View full text Add to dashboard Cite

show abstract

“…At study entry and annually, we measured BP, BMI, waist‐hip ratio (WHR), and depressive symptoms using the modified Center for Epidemiologic Studies Depression scale (mCES‐D) . Consenting participants provided blood samples for APOE genotyping.…”

Section: Methodsmentioning

confidence: 99%

Aging, Diabetes, Obesity, and Cognitive Decline: A Population‐Based Study

Ganguli

Beer

Zmuda

et al. 2020

J American Geriatrics Society

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES: To investigate potential mechanisms underlying the well-established relationship of diabetes and obesity with cognitive decline, among older adults participating in a population-based study. DESIGN/SETTING: Ten-year population-based cohort study. PARTICIPANTS: A total of 478 individuals aged 65 years and older. MEASUREMENTS: We assayed fasting blood for markers of glycemia (glucose and hemoglobin A1c [HbA1c]), insulin resistance (IR) (insulin and homeostatic model assessment of IR), obesity (resistin, adiponectin, and glucagon-like peptide-1), and inflammation (C-reactive protein). We modeled these indices as predictors of the slope of decline in global cognition, adjusting for age, sex, education, APOE*4 genotype, depressive symptoms, waist-hip ratio (WHR), and systolic blood pressure, in multivariable regression analyses of the entire sample and stratified by sex-specific median WHR. We then conducted WHRstratified machine-learning (Classification and Regression Tree [CART]) analyses of the same variables. RESULTS: In multivariable regression analyses, in the entire sample, HbA1c was significantly associated with cognitive decline. After stratifying by median WHR, HbA1c remained associated with cognitive decline in those with higher WHR. No metabolic indices were associated with cognitive decline in those with lower WHR. Cross-validated WHR-stratified CART analyses selected no predictors in participants older than 87 to 88 years. Faster cognitive decline was associated, in lower WHR participants younger than 87 years, with adiponectin of 11 or greater; and in higher WHR participants younger than 88 years, with HbA1c of 6.2% or greater. CONCLUSIONS: Our population-based data suggest that, in individuals younger than 88 years with central obesity, even modest degrees of hyperglycemia might independently predispose to faster cognitive decline. In contrast, among those younger than 87 years without central obesity, adiponectin may be a novel independent risk factor for cognitive decline. J Am Geriatr Soc 68:991-998, 2020.

show abstract

“…Because these two parameters were associated with cognition and balance [26,27] , so BMI and abdominal circumference were used as covariates in the statistical analysis. By adjusting the covariates of BMI and abdominal circumference, the data of postural and cognitive performance in the single or dual tasks were assessed using a mixed model analysis of covariance.…”

Section: Discussionmentioning

confidence: 99%

How cognitive loads modulate the postural control of older women with low back pain ?

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The capacity of postural control is a key factor related to falling in older people, particularly in older women with low back pain (LBP). Cognitive involvement in postural control increases with age. However, most scholars have not considered different difficulty levels of cognitive loads when exploring the effects of cognition on postural control in older patients with LBP. The present study is to investigate how different levels of cognitive loads modulate postural control in older women with LBP.Methods: This was a cross-sectional study. Twenty older women with LBP were recruited into the LBP group, and 20 healthy older women without the history of LBP were recruited into the healthy control group. Balance parameters were computed to quantify postural control. All participants underwent the balance test , which required the participant to maintain stability during standing on a force platform with or without a concurrent cognitive task. The balance test included three levels of difficulties of posture tasks (eyes-open vs. eyes-closed vs. one-leg stance) and three cognitive tasks (without cognitive task vs. auditory arithmetic task vs. serial-7s arithmetic task). Results: A repeated-measure analysis of variance (3 postural tasks × 3 congnitive tasks× 2 groups) testing the effects of the different congnitive task levels on the performance in different postural conditions.Older women with LBP had worse postural control (as reflected by larger center of pressure (COP) parameters) than control group regardless of postural or cognitive difficulties. Compared with the single task, the COP parameters of participants with LBP were larger during dual tasks, even though the difficulty level of the cognitive task was low. Larger COP parameters were shown only if the difficulty level of the cognitive task was high in control group. Correlations between sway area/sway length and the number of falls were significant in dual tasks.Conclusion: Our findings shed light on how cognitive loads modulate postural control for older women with LBP. Compared with control group, cognitive loads showed more disturbing effects on postural control in older women with LBP, which was associated with falling.

show abstract

The association between body mass index, waist circumference, waist–hip ratio and cognitive disorder in older adults

Abstract: BMI obesity and WC/WHR central obesity have a combined effect on cognitive impairment and WHR has a stronger association with cognitive impairment than WC.

Cited by 54 publications

References 13 publications

<p>Associations between obesity and cognitive impairment in the Chinese elderly: an observational study</p>

<p>Associations between obesity and cognitive impairment in the Chinese elderly: an observational study</p>

Aging, Diabetes, Obesity, and Cognitive Decline: A Population‐Based Study

How cognitive loads modulate the postural control of older women with low back pain ?

Contact Info

Product

Resources

About