The Association between Brain-Derived Neurotrophic Factor (BDNF) Protein Level and Body Mass Index

Taha, Murtada; Al-Maqati, Thekra N; Naam, Yaser A. Al; Alharbi, Sulaiman S.; Khaneen, Rajaa; Almutairi, Hajra; AL-harbi, Mashael

doi:10.3390/medicina59010099

Cited by 8 publications

(3 citation statements)

References 41 publications

(51 reference statements)

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“…Masataka Suwa et al found a positive correlation between serum BDNF level and BMI in female diabetic patients [18] . A study found that people with different BMI levels have different serum BDNF levels, with underweight being the highest, followed by normal BMI, and the higher the degree of obesity, the lower the level of BDNF [19] . However, the results of this study showed that there was no significant difference in the degree of BDNF level increase in patients with different degrees of obesity after bariatric surgery, which may be related to the small sample size of the study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Changes in BDNF Levels Before and After Bariatric Surgery in Obese Patients

Zhang,

Xu,

Liu

et al. 2023

JCNR

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Objectives: The rate of obesity has been increasing globally, so is the number of obese patients undergoingbariatric surgery. The relationship between brain-derived neurotrophic factor (BDNF) and body weight has beenhighlighted in recent years, but there are few related studies in China. The purpose of this study was to investigate the changes of BDNF in obese patients before and after bariatric surgery and to provide evidence for obesity-related mechanisms. Methods: The BDNF levels in 44 obese patients who underwent bariatric surgery were measured by enzyme-linked immunosorbent assay (ELISA) before and 4.5 months after surgery. SPSS 27.0 was used for statistical analysis. Results: Among the 44 patients, 30 were female and 14 were male. The body mass index (BMI) decreased significantly after bariatric surgery (P < 0.001); the serum BDNF of the patients significantly increased (P < 0.001) after surgery. There was no significant difference in BDNF among patients with different degrees of obesity before and after surgery (P > 0.05). There were no significant differences in BMI and BDNF levels between different sexes before and after surgery (P > 0.05). Conclusion: The BDNF levels of obese patients increased significantly after bariatric surgery, which proved that bariatric surgery has an effect on BDNF levels.

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Section: Discussionmentioning

confidence: 99%

Analysis of Changes in BDNF Levels Before and After Bariatric Surgery in Obese Patients

Zhang,

Xu,

Liu

et al. 2023

JCNR

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“…A study of serum BDNF levels in severely obese patients from Saudi Arabia showed a significant correlation between a low BDNF expression and a high BMI. 56 A negative correlation also was found between plasma BDNF levels and IR. Similar results were obtained in experimental animals with diabetes and obesity.…”

Section: Receptorsmentioning

confidence: 92%

(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review

Todosenko,

Yurova,

Khaziakhmatova

et al. 2024

Gene Expr

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A key element in the pathogenesis of metabolic syndrome (MetS) is the reprogramming of hypothalamic cells at the genetic level (in the prenatal phase), which leads to neuroinflammation. We hypothesize that alterations in the structure of hypothalamic neurons mediated by (epi)genetic alterations are directly related to impaired expression/production of neurotrophins and neurotransmitters that control the metabolism of substances in the brain and periphery, including brain-derived neurotrophic factor (BDNF). The aim of this review is to describe the molecular genetic and epigenetic role of BDNF in the development of MetS. Articles entered into the National Library of Medicine Medline database via the PubMed interface were used to create this review. We attempted to include as much literature as possible, including reviews, animal studies, cell culture studies, and clinical trials. Studies on BDNF point to its role in metabolic processes, including glucose, insulin, and cholesterol homeostasis. Evidence-based studies show that multiple genes in close proximity to BDNF are involved in the development of MetS. Studies aimed at analyzing BDNF in metabolic diseases using different biological samples will reveal clear pathophysiological links

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“…Modern research progress has played a significant role in sustaining high levels of healthcare and general well-being. Although conventional technologies like real-time polymerase chain reaction (RT-PCR) [ 1 , 2 ], enzyme-linked immunosorbent assay (ELISA) [ 3 ], high-performance liquid chromatography (HPLC) [ 4 ], gas chromatography–mass spectrometry (GCMS) [ 5 ], and so on demonstrate high sensitivity and accuracy, the complex and costly equipment required could cause a delay in response time. This highlights the essential need in biosensor and bioassay research for the development of rapid, portable, and user-friendly assays that could accelerate the diagnostic process and alleviate treatment delay [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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This review highlights the recent advancements in the field of nanozymes and their applications in the development of point-of-care biosensors. The use of nanozymes as enzyme-mimicking components in biosensing systems has led to improved performance and miniaturization of these sensors. The unique properties of nanozymes, such as high stability, robustness, and surface tunability, make them an attractive alternative to traditional enzymes in biosensing applications. Researchers have explored a wide range of nanomaterials, including metals, metal oxides, and metal–organic frameworks, for the development of nanozyme-based biosensors. Different sensing strategies, such as colorimetric, fluorescent, electrochemical and SERS, have been implemented using nanozymes as signal-producing components. Despite the numerous advantages, there are also challenges associated with nanozyme-based biosensors, including stability and specificity, which need to be addressed for their wider applications. The future of nanozyme-based biosensors looks promising, with the potential to bring a paradigm shift in biomolecular sensing. The development of highly specific, multi-enzyme mimicking nanozymes could lead to the creation of highly sensitive and low-biofouling biosensors. Integration of nanozymes into point-of-care diagnostics promises to revolutionize healthcare by improving patient outcomes and reducing costs while enhancing the accuracy and sensitivity of diagnostic tools.

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The Association between Brain-Derived Neurotrophic Factor (BDNF) Protein Level and Body Mass Index

Cited by 8 publications

References 41 publications

Analysis of Changes in BDNF Levels Before and After Bariatric Surgery in Obese Patients

Analysis of Changes in BDNF Levels Before and After Bariatric Surgery in Obese Patients

(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

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