The association between carcinoma of the pancreas and diabetes mellitus

Karmody, A. J.; Kyle, James

doi:10.1002/bjs.1800560512

Cited by 65 publications

(24 citation statements)

References 11 publications

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“…Our data provide objective support for the clinical impression that diabetics with pancreatic cancer tend to have diabetes of higher severity, and provide another clinical clue that may aid in the identification of diabetic individuals with pancreatic cancer (34,39).…”

Section: Discussionsupporting

confidence: 55%

Diabetes Mellitus and Pancreatic Cancer in a Population-Based Case-Control Study in the San Francisco Bay Area, California

Wang

Gupta²,

Holly³

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

104

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Background: Diabetes has been postulated to be both a risk factor and a consequence of pancreatic cancer, but the degree of risk and associated clinical factors remain unclear. Methods: We conducted a population-based case-control study of pancreatic cancer in the San Francisco Bay Area between 1995 and 1999. Rapid case ascertainment through the Surveillance, Epidemiology and End Results registry for cases and random selection from the general population for controls were employed to identify study participants with no proxy interviews. Results: Five hundred thirty-two cases and 1,701 controls were interviewed. Participants with pancreatic cancer were more likely to report a history of diabetes (13%) than were controls [9%; odds ratio (OR), 1.5; 95% confidence interval (95% CI), 1.1-2.1]. Compared with diabetics in the control

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Section: Discussionsupporting

confidence: 55%

Diabetes Mellitus and Pancreatic Cancer in a Population-Based Case-Control Study in the San Francisco Bay Area, California

Wang

Gupta²,

Holly³

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

104

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“…3,4 In the series by Homma and Tsuchiya, 4 mass screening of 10,162 patients age Ͼ 40 years yielded only 4 patients (0.04%) with pancreatic carcinoma using serum CA19-9 and elastase-1 in combination with ultrasonography, whereas 85 of 4506 outpatients (1.9%) with gastrointestinal complaints or jaundice had pancreatic carcinoma. Many reports emphasized the correlation between pancreatic carcinoma and diabetes mellitus, [5][6][7][8] but pancreatic carcinoma is not frequent, even in patients with diabetes. Kessler 5 documented 78 deaths (0.4%) from pancreatic carcinoma among 21,447 diabetic patients, a rate that was only approximately twice as much as the statistically standardized incidence rate in nondiabetic population.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] Karmody and Kyle 7 and Gullo et al 8 reported the association between recent-onset diabetes and the development of pancreatic carcinoma. However, no criteria have been established to efficiently identify high-risk groups among diabetic patients.…”

mentioning

confidence: 99%

A prospective pancreatographic study of the prevalence of pancreatic carcinoma in patients with diabetes mellitus

Ogawa

Tanaka

Inoue

et al. 2002

Cancer

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BACKGROUNDThe correlation between diabetes mellitus and pancreatic carcinoma is well documented, but no criteria have been established for the efficient selection of a high‐risk group among patients with diabetes mellitus.METHODSEighty‐seven patients were selected prospectively from outpatients with diabetes and underwent endoscopic retrograde pancreatography (ERP) according to the authors' original criteria, including the onset of diabetes after age 55 years, deterioration of diabetes or loss of body weight despite strict medical control, elevation of serum amylase and/or CA19‐9 levels, and pancreatobiliary abnormalities on routine ultrasonography. The patients were divided into two groups according to the time from the onset of diabetes to ERP: Patients in Group A had recent‐onset diabetes (within 3 years), and Group B patients had diabetes for > 3 years.RESULTSA total of 86 patients (excluding 1 patient with unsuccessful ERP who had undergone previous Billroth‐2 gastrectomy) were enrolled. There were 33 males and 53 females, age 40–90 years, with a mean age of 65.1 years. ERP demonstrated pancreatic carcinoma, although it was advanced disease in all patients, at an extremely high rate of 7.0% (6 of 86 patients) with no serious complications. The prevalence of pancreatic carcinoma in Group A (13.9%; 5of 36 patients) was significantly greater compared with Group B (2.0%; 1 of 50 patients; P = 0.0442). ERP with an indwelling balloon catheter and subsequent pancreatic juice sampling was performed in 49 patients, yielding positive cytology in 1 patient with pancreatic tail carcinoma, whereas measurements of carcinoembryonic antigen and CA19‐9 levels in pancreatic juice were of no use in the diagnosis of pancreatic carcinoma.CONCLUSIONSSelective ERP in patients with diabetes who were at high risk did not lead to the early diagnosis of pancreatic carcinoma, although this study showed that the 3‐year period after the onset of diabetes was critical. A more aggressive diagnostic approach within this period in diabetic patients with the authors' criteria may contribute to the earlier diagnosis of pancreatic carcinoma. Cancer 2002;94:2344–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10493

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“…Nearly 80% patients of pancreatic cancer (PC) have impaired glucose metabolism, either frank diabetes or impaired glucose tolerance (IGT )1, 2 and the majority of diabetes associated with PC is diagnosed either concomitantly or during the two years before the diagnosis of PC 3 Karmody and Kyle reported that PC was diagnosed within one year from the onset of the diabetes in 40 out of 51 patients (78.4%) 4 According to Gullo et al 5 , diabetes in patients with PC is frequently (56.1%) of the recent onset type and is presumably caused by the tumor. In this study, in 43.9% of the patients, the diagnosis of diabetes preceeded the diagnosis of PC by three years and in 37.2% it was five or more years.…”

Section: Introductionmentioning

confidence: 99%

“…In recent studies, however, when the latency period between the onset of diabetes and PC was considered, the issue became muddled. In some studies, when the patients with short latency periods were excluded from the sample size, the relative risk of diabetes for PC was markedly diminished [3][4][5] . In another population-based case control study, a significant positive trend in risk for PC was detected (p=0.016) in patients with diabetes diagnosed ten or more years prior to cancer detection 10 .The meta-analysis of more than 20 epidemiologic studies indicated the relative risk of PC for diabetics diagnosed at least five years prior to the diagnosis of cancer as 2.0 11 .…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes and Pancreatic Cancer – A Possible Reason

Pour¹

2011

Medical Complications of Type 2 Diabetes

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The association between carcinoma of the pancreas and diabetes mellitus

Cited by 65 publications

References 11 publications

Diabetes Mellitus and Pancreatic Cancer in a Population-Based Case-Control Study in the San Francisco Bay Area, California

Diabetes Mellitus and Pancreatic Cancer in a Population-Based Case-Control Study in the San Francisco Bay Area, California

A prospective pancreatographic study of the prevalence of pancreatic carcinoma in patients with diabetes mellitus

Type 2 Diabetes and Pancreatic Cancer – A Possible Reason

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