The association between changes in echocardiography and risk of heart failure hospitalizations and death in adults with chronic kidney disease

Fitzpatrick, Jesse K.; Parikh, Rishi; Hamilton, Steven A.; Ambrosy, Andrew P.; Tan, Thida C.; Bansal, Nisha; Go, Alan S.; Appel, Lawrence J.; Chen, Jing; Lash, James P.; Nelson, Robert G.; Rahman, Mahboob; Rao, Panduranga S.; Shah, Vallabh O.; Townsend, Raymond R.; Unruh, Mark

doi:10.1038/s41598-023-35440-w

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Data from the Chronic Renal Insufficiency Cohort (CRIC) Study revealed a close interaction between cardiac structure and the risk of renal failure in a population with CKD, hypothesizing that cardiac abnormalities and renal damage are based on the same causal pathways, related to the interaction between hypertension, heart failure, and coronary artery diseases [5]. Furthermore, other prognostic evidence has been assessed among adults with CKD, revealing a causal link between adverse cardiac remodeling and increased risk of heart failure-related morbidity and mortality [6].…”

Section: Introductionmentioning

confidence: 99%

Left Ventricular Mass Index Predicts Renal Function Decline in Patients with Chronic Kidney Disease

Lacquaniti,

Ceresa,

Campo

et al. 2024

Medicina

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Background and Objectives: Several studies revealed a relation between abnormal cardiac remodeling and glomerular filtration rate (GFR) decline, but there are limited data regarding echocardiographic changes in chronic kidney disease (CKD). This study evaluated the abnormal cardiac structures characterizing patients with CKD, assessing the independent association between echocardiographic parameters and the risk of decline in renal function. Materials and Methods: In total, 160 patients with CKD were studied. All patients underwent an echocardiographic exam and 99mTc-DTPA renal scintigraphy to measure the GFR. After the baseline assessments, patients were followed prospectively for 12 months, or until the endpoint achievement, defined as a worsening in renal function (doubling of baseline serum creatinine, GFR decline ≥25%, the start of dialysis). Results: Patients with GFR values of 34.8 ± 15 mL/min, identifying stages III–IV of CKD, were associated with high levels of left ventricular mass index (LVMi) (101.9 ± 12.2 g/m2), which was related to proteinuria, systolic blood pressure, and pulmonary artery systolic pressure in a multiple regression model. During the observational period, 26% of patients reached the endpoint. Regression analysis revealed LVMi as a predictor of change in renal function after adjusting for kidney and cardiac risk factors. Multiple Cox regression indicated that an increase in LVMi was associated with a 12% increased risk of kidney disease progression (HR: 1.12; 95% CI: 1.04–1.16; p = 0.001). Conclusions: In patients with CKD, high LVMi represents an independent predictor of the progressive decline of the renal function, until the start of renal replacement therapy. Echocardiography can help identify patients at high risk for renal disease worsening in patients with CKD independently of clinical cardiac involvement.

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Section: Introductionmentioning

confidence: 99%

Left Ventricular Mass Index Predicts Renal Function Decline in Patients with Chronic Kidney Disease

Lacquaniti,

Ceresa,

Campo

et al. 2024

Medicina

View full text Add to dashboard Cite

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The Interplay of Comorbidities in Chronic Heart Failure: Challenges and Solutions

Agress,

Sheikh,

Perez Ramos

et al. 2024

CCR

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Background: Chronic heart failure (HF) is frequently associated with various comorbidities. These comorbid conditions, such as anemia, diabetes mellitus, renal insufficiency, and sleep apnea, can significantly impact the prognosis of patients with HF. Objective: This review aims to synthesize current evidence on the prevalence, impact, and management of comorbidities in patients with chronic HF. Methods: A comprehensive review was conducted, with a rigorous selection process. Out of an initial pool of 59,030 articles identified across various research modalities, 134 articles were chosen for inclusion. The selection spanned various research methods, from randomized controlled trials to observational studies. Results: Comorbidities are highly prevalent in patients with HF and contribute to increased hospitalization rates and mortality. Despite advances in therapies for HF with reduced ejection fraction, options for treating HF with preserved ejection fraction remain sparse. Existing treatment protocols often lack standardization, reflecting a limited understanding of the intricate relationships between HF and associated comorbidities. Conclusion: There is a pressing need for a multidisciplinary, tailored approach to manage HF and its intricate comorbidities. This review underscores the importance of ongoing research efforts to devise targeted treatment strategies for HF patients with various comorbid conditions.

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The association between changes in echocardiography and risk of heart failure hospitalizations and death in adults with chronic kidney disease

Cited by 2 publications

References 25 publications

Left Ventricular Mass Index Predicts Renal Function Decline in Patients with Chronic Kidney Disease

Left Ventricular Mass Index Predicts Renal Function Decline in Patients with Chronic Kidney Disease

The Interplay of Comorbidities in Chronic Heart Failure: Challenges and Solutions

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