The association between chronic obstructive pulmonary disease and dementia: a population‐based retrospective cohort study

Liao, Wei; Lin, Cheng‐Chieh; Chang, Shih Ni; Tu, Chih‐Yen; Kao, Chia Hung

doi:10.1111/ene.12573

Cited by 48 publications

(69 citation statements)

References 35 publications

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“…48.5 % of COPD patients were reported to have cognitive impairment (Incalzi et al 1993). Recently, prospective studies confirm that COPD increases the risk of mild cognitive impairment (MCI) and dementia (Liao et al 2015;Singh et al 2013Singh et al , 2014. However, the molecular mechanism for the association of COPD and its risk of dementia is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Cognitive impairment, more prevalent among COPD patients (Antonelli-Incalzi et al 2007), has been viewed as one of the important extrapulmonary manifestation in patients with COPD (Ortapamuk and Naldoken 2006). Recently, a nationwide retrospective cohort study demonstrated that COPD is associated with increased risk of dementia (Liao et al 2015). However, the molecular event underlying is still not completely understood.…”

Section: Introductionmentioning

confidence: 99%

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Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

Cao

Shen

et al. 2015

Neurotox Res

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Chronic obstructive pulmonary disease (COPD) is associated with cognitive decline, but the molecular link between COPD and dementia or Alzheimer's disease (AD) remains unclear. This study was aimed to investigate whether serum Aβ levels are correlated with COPD. 77 cognitively normal COPD patients and 45 age- and gender-matched normal controls were admitted to the study. Serum Aβ40 and Aβ42 levels were measured using ELISA kits. Serum C-reactive protein (CRP), interleukin 6 (IL-6), and procalcitonin (PCT) measurements were done using standard laboratory methods. Pulmonary function tests were performed to assess the pulmonary function and determine the degree of lung damage. Significantly increased levels of serum Aβ40, Aβ42, and total Aβ levels were found in patients with COPD in comparison with normal controls. In COPD patients, serum Aβ levels were higher in subjects with serum CRP, IL-6, and PCT upper the limit of normal. Moreover, serum Aβ levels were dramatically higher in COPD patients with worse pulmonary function. Our study suggests that cognitively normal COPD patients may undergo AD-related pathological changes, and COPD might facilitate AD-type pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

Cao

Shen

et al. 2015

Neurotox Res

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“…The risk of depression was elevated fourfold among those with a COPD-related hospitalization [5]. COPD may also increase risk for dementia [6]. And depending on the extent of patient dependency, caregivers of persons with COPD have elevated rates of health-related problems [7].…”

Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 99%

Psychiatric and Medical Comorbidity in the Primary Care Geriatric Patient—An Update

Kennedy

Castro

Chang

et al. 2016

Curr Psychiatry Rep

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The mental health needs of older primary care patients are now widely recognized if not widely addressed. The range of behavioral health approaches including co-locating psychiatrists and integrating mental health professionals as care managers into primary care sites is extensive and growing. Nonetheless the primary care provider remains the first line of defense against mental disorders, most commonly depression and anxiety that accompany and exacerbate common physical conditions. The excess, potentially avoidable disability that results from comorbidity makes it imperative that early recognition and evidence based intervention occur. Multi-morbidity and polypharmacy make intervention a challenge. Psychotherapy can help overcome comorbidity depression however the most accessible intervention would be an antidepressant FDA approved for both anxiety and depressive disorders. For all these reasons, a focus on physical conditions most commonly associated with mental disorders can foster early recognition before the older patient's care becomes overwhelmingly complicated.

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“…Cognitive decline is common in severe congestive heart failure [26] and heart disease overall [27]. Chronic obstructive pulmonary disease (COPD) is also associated with dementia, especially in patients with frequent exacerbations [28]. Chronic kidney disease is independently associated with all-cause dementia in patients with vascular risk factors [29].…”

Section: Introductionmentioning

confidence: 99%

Are we Providing the Best Possible Care for Dementia Patients?

Borisovskaya

Chen

Borson

2015

Neurodegener. Dis. Manag.

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Healthcare for patients with dementia is often reactive, poorly organized and fragmented. We discuss opportunities for improvements in the care of individuals living with dementia at home that can be implemented by physicians in their practices today. In particular, we argue that systematic identification and diagnosis of cognitive impairment and dementia in their early stages, coupled with a coherent, evidence-informed management framework, would benefit patients with dementia substantially and ease the burden of their caregivers. We emphasize that dementia influences all aspects of patient care, and each medical decision must be passed through the filter of knowledge that patients with dementia have special needs that can be identified and addressed.

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The association between chronic obstructive pulmonary disease and dementia: a population‐based retrospective cohort study

Abstract: This study shows that COPD is associated with a subsequent higher risk of dementia after adjusting for comorbidities. Specifically, the association between COPD and dementia is greater in patients with more frequent acute exacerbation events of COPD.

Cited by 48 publications

References 35 publications

Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

Psychiatric and Medical Comorbidity in the Primary Care Geriatric Patient—An Update

Are we Providing the Best Possible Care for Dementia Patients?

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