The association between circadian rhythm of cortisol and shift work regularity among midwives—A multicenter study in Southeast China

Huang, Xizhen; Jiang, Xiumin; Zheng, Qing‐Xiang; Chen, Xiaoqian

doi:10.3389/fpubh.2022.965872

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…We expected to find a correlation between cortisol levels and the amount of sleep disruption; however, we found none. Cortisol secretion is reported to be elevated in several cohorts of sleep-deprived shift workers [ 18 , 23 - 28 ] including firefighters [ 29 , 30 ]. We expected to find a significant positive correlation between salivary cortisol levels and perceived stress like what has been reported in Saudi dental students during periods of academic exams [ 31 ], but we found a significant negative correlation, only on day 3 at the end of the 72-hour shift.…”

Section: Discussionmentioning

confidence: 99%

A Study of Diurnal Cortisol Adaptations in Sleep-Deprived Firefighters During a 72-Hour Work Shift: A Case Series

Sundberg¹,

Millis²

2023

Cureus

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Seventy percent of US firefighters are overweight or obese. The combination of sleep deprivation and exposure to traumatic events during 72-hour work shifts, commonly employed in emergency responders, is thought to put firefighters at high risk for a variety of stress-related diseases and suicide. Previous studies suggest that the cortisol awakening response (CAR) may be increased in sleep-deprived emergency responders. This case series was designed to investigate the variations in CAR and associations with measurements of salivary cortisol and testosterone, blood glucose and triglyceride, and blood pressure during a 72-hour work shift. Measurements were made at 08:00 and 20:00 in five participants (one normal weight normotensive, three obese hypertensive, and one morbidly obese normotensive male). Data were characterized by the regression statistic R 2 computed from the relationship between diurnal measurement and concentration, with significance at R 2 ≥0.4. The predominant AM CAR adaptation response consisted of no significant 72-h change (flat response) in salivary cortisol (R 2 <0.4), found in three of the five participants (60%). The normal-weight participant’s 72-h AM CAR adaptation was characterized as incremental (R 2 =0.91), and markedly different than that of the four obese firefighters who exhibited either a flat response (R 2 <0.4, 60%) or, in one subject, a decremental response (R 2 =0.40, 20%). The predominant 72-h PM cortisol adaptation was found to be decremental (R 2 =0.78-0.97) in three of the five participants (60%), including the normal weight subject (R 2 =0.78). Diurnal salivary cortisol and testosterone exhibited normal physiological circadian variations (P=0.01, AM>PM and P=0.1, AM>PM, respectively). Blood glucose and triglyceride also showed physiological circadian variations (P=0.02 AM

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Section: Discussionmentioning

confidence: 99%

A Study of Diurnal Cortisol Adaptations in Sleep-Deprived Firefighters During a 72-Hour Work Shift: A Case Series

Sundberg¹,

Millis²

2023

Cureus

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Association between circadian syndrome and the prevalence of kidney stones in overweight adults: a cross-sectional analysis of NHANES 2007–2018

et al. 2023

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Objective To explore the association between circadian syndrome (CircS) and the prevalence of kidney stones in overweight people. Materials and methods A cross-sectional analysis was conducted based on the NHANES 2007–2018. Overweight people aged ≥ 20 years were the target population. Three multivariable logistic regression models were built to examine the association between CircS and kidney stones. Subgroup analysis based on age, gender, and race were also employed. Interaction and stratification analysis was also conducted to identify whether some factors modify the association. Result A total of 4,603 overweight participants were included in the study. The multivariable logistic regression suggested that CircS was positively associated with the prevalence of kidney stones (OR = 1.422, 95% CI 1.057 to 1.912). The subgroup analysis showed that the association was more obvious in females (OR = 1.604, 95% CI 1.023 to 2.516) or in the population aged 35 to 49 years old (OR = 2.739, 95% CI 1.428 to 5.254). Additionally, the same trend was present when people were Mexican American (OR = 3.834, 95% CI 1.790 to 8.215) or other races (OR = 4.925, 95% CI 1.776 to 13.656). The interaction and stratification analysis showed that the results above were robust. Conclusion CircS was positively associated with the prevalence of kidney stones in overweight people, especially people as females, aged 35 to 49, and Mexican Americans.

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Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk

Dobrovinskaya,

Alamilla,

Olivas-Aguirre

2024

Cancers

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Background: Recent research underscores a crucial connection between circadian rhythm disruption and cancer promotion, highlighting an urgent need for attention. Objectives: Explore the molecular mechanisms by which modern lifestyle factors—such as artificial light exposure, shift work, and dietary patterns—affect cortisol/melatonin regulation and cancer risk. Methods: Employing a narrative review approach, we synthesized findings from Scopus, Google Scholar, and PubMed to analyze lifestyle impacts on circadian health, focusing on cortisol and melatonin chronobiology as molecular markers. We included studies that documented quantitative changes in these markers due to modern lifestyle habits, excluding those lacking quantitative data or presenting inconclusive results. Subsequent sections focused solely on articles that quantified the effects of circadian disruption on adipogenesis and tumor microenvironment modifications. Results: This review shows how modern habits lead to molecular changes in cortisol and melatonin, creating adipose microenvironments that support cancer development. These disruptions facilitate immune evasion, chemotherapy resistance, and tumor growth, highlighting the critical roles of cortisol dysregulation and melatonin imbalance. Conclusions: Through the presented findings, we establish a causal link between circadian rhythm dysregulation and the promotion of certain cancer types. By elucidating this relationship, the study emphasizes the importance of addressing lifestyle factors that contribute to circadian misalignment, suggesting that targeted interventions could play a crucial role in mitigating cancer risk and improving overall health outcomes.

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The association between circadian rhythm of cortisol and shift work regularity among midwives—A multicenter study in Southeast China

Cited by 3 publications

References 23 publications

A Study of Diurnal Cortisol Adaptations in Sleep-Deprived Firefighters During a 72-Hour Work Shift: A Case Series

A Study of Diurnal Cortisol Adaptations in Sleep-Deprived Firefighters During a 72-Hour Work Shift: A Case Series

Association between circadian syndrome and the prevalence of kidney stones in overweight adults: a cross-sectional analysis of NHANES 2007–2018

Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk

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