The association between coffee consumption and bladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study

Sugiyama, Kemmyo; Sugawara, Yumi; Tomata, Yasutake; Nishino, Yoshikazu; Fukao, Akira; Tsuji, Ichiro

doi:10.1097/cej.0000000000000226

Cited by 26 publications

(21 citation statements)

References 39 publications

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“…It could, therefore, be suggested that the increased BC risk is due to the caffeine content of coffee. Previous epidemiological studies already confirmed this hypothesis by showing a null association between BC risk and decaffeinated coffee [71] and an increased BC risk for caffeinated coffee [72,73]. The present study also showed an increased BC risk when comparing caffeinated coffee consumers versus decaffeinated coffee consumers.…”

Section: Discussionsupporting

confidence: 88%

The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

Wesselius

Osch

et al. 2019

Cancer Causes Control

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Background Inconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case-control studies on this topic. Methods Data were collected from 13 case-control comprising of 5,911 cases and 16,172 controls. Pooled multivariate odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models. Furthermore, linear dose-response relationships were examined using fractional polynomial models. Results No association of BC risk was observed with coffee consumption among smokers. However, after adjustment for age, gender, and smoking, the risk was significantly increased for never smokers (ever vs. never coffee consumers: OR model2 1.30, 95% CI 1.06-1.59; heavy (> 4 cups/day) coffee consumers vs. never coffee consumers: OR model2 1.52, 95% CI 1.18-1.97, p trend = 0.23). In addition, dose-response analyses, in both the overall population and among never smokers, also showed a significant increased BC risk for coffee consumption of more than four cups per day. Among smokers, a significant increased BC risk was shown only after consumption of more than six cups per day. Conclusion This research suggests that positive associations between coffee consumption and BC among never smokers but not smokers.

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Section: Discussionsupporting

confidence: 88%

The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

Wesselius

Osch

et al. 2019

Cancer Causes Control

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“…However, this positive association was restricted to ever smokers, particularly current smokers, and we observed no evidence of an association among never smokers. Previous prospective cohort studies, conducted in the United States, Europe, and Asia, with smoking-adjusted analyses have provided little evidence for a positive, independent, dose-response relationship between coffee drinking and risk of bladder cancer, 17–24 and two studies observed inverse associations among adults in Japan 25 and women in the Netherlands. 26 Nevertheless, positive associations in case-control studies, 27 which are difficult to interpret due to potential recall and selection bias, as well as suggestive, but imprecise positive trends in some cohort studies 20, 22, 24, 26 have sustained speculation that coffee drinking causes bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, the few cohort studies that have conducted sensitivity analyses among never smokers have had very limited case numbers in this subgroup, and risk estimates have been imprecise and inconsistent. 20, 25, 26 …”

Section: Discussionmentioning

confidence: 99%

A Prospective Investigation of Coffee Drinking and Bladder Cancer Incidence in the United States

et al. 2017

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Background In 1991, coffee was classified as a Group 2B carcinogen, possibly carcinogenic to humans, based on limited epidemiologic evidence of a positive association with bladder cancer. In 2016, the International Agency for Research on Cancer downgraded this classification due to lack of evidence from prospective studies particularly for never smokers. Methods Baseline coffee drinking was assessed with a food frequency questionnaire in the NIH-AARP prospective cohort study. Among 469 047 US adults, who were cancer-free at baseline, 6012 bladder cancer cases (5088 men and 924 women) were identified during >6.3 million person years of follow-up. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI), with non-coffee drinkers as the reference group. Results Coffee drinking was positively associated with bladder cancer in models adjusted for age and sex (hazard ratio [HR] for ≥4 cups/day relative to coffee nondrinkers=1.91, 95% CI=1.70–2.14; P-trend<0.0001). However, the association was substantially attenuated after adjustment for cigarette smoking and other potential confounders (HR for ≥4 cups/day relative to coffee nondrinkers=1.18 95% CI=1.05–1.33; P-trend=0.0007). Associations were further attenuated after additional adjustment for lifetime smoking patterns among the majority of the cohort with this available data (P-trend=0.16). There was no evidence of an association among never smokers (P-trend=0.84). Conclusions Positive associations between coffee drinking and bladder cancer among ever smokers but not never smokers suggest that residual confounding from imperfect measurement of smoking or unmeasured risk factors may be an explanation for our positive findings.

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“…We carried out a pooled analysis of two prospective cohort studies, the Miyagi Cohort Study and the Ohsaki Cohort Study, details of which have been described previously elsewhere. [9][10][11] In brief, for the Miyagi Cohort Study, we distributed a self-administered questionnaire to all 51,921 subjects (26,642 women and 25,279 men) aged 40-64 years resident in 14 municipalities of Miyagi Prefecture, northeastern Japan, between June and August 1990. We collected eligible questionnaires from 24,769 47,605 of those subjects (response rate: 91.7%).…”

Section: Study Populationmentioning

confidence: 99%

Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

Wakamatsu

Sugawara

Zhang

et al. 2018

Intl Journal of Cancer

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It is unclear whether weight change during adulthood affects the risk of obesity-related cancers such as those of the esophagus, colorectum, pancreas, breast, endometrium, and kidney among Japanese, where obesity is less frequent and less severe. We examined the association between weight change during adulthood and the risk of obesity-related cancer among Japanese by conducting a pooled analysis of two prospective studies of residents in Miyagi Prefecture, Japan. A total of 78,743 persons (40,422 women and 38,321 men) aged 40-79 years participated in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994. Weight change since age 20 was divided into four categories (weight loss; stable weight; moderate weight gain; high weight gain). Cox proportional hazards regression analysis was used to estimate the multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for obesity-related cancer incidence. During 1,057,899 person-years of follow up, 4,467 cases of obesity-related cancer (women; 1,916 cases, men; 2,551cases) were identified. In women, compared to the stable weight, weight gain was associated with an increased risk of obesity-related cancer (moderate weight gain; HRs = 1.10, 95%CIs: 0.97-1.26, high weight gain; HRs = 1.29, 95%CIs: 1.14-1.47). The results indicate that weight gain since age 20 was associated with a significantly increased risk of obesity-related cancer among Japanese women. By contrast, in men, our study found that weight change is not associated with the incidence of obesity-related cancer.

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The association between coffee consumption and bladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study

Cited by 26 publications

References 39 publications

The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

A Prospective Investigation of Coffee Drinking and Bladder Cancer Incidence in the United States

Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

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