The association between complement factor H rs1061170 polymorphism and age‐related macular degeneration: a comprehensive meta‐analysis stratified by stage of disease and ethnicity

Abstract

Purpose: The strength of association between complement factor H (CFH) rs1061170 polymorphism and age-related macular degeneration (AMD) differs between AMD subtypes and ethnicities. The main aim was to provide a systematic review and an updated meta-analysis stratified by stage of disease and ethnicity. Methods: A literature search in the PubMed-Medline, EMBASE and Web of Science databases was conducted to identify epidemiological studies, published before September 2017, that included at least twp comparison groups (a control group with no signs of AMD and a case group of AMD patients). Genotype distribution, phenotype of the cases, ethnicity, mean age and gender ratio were collected. Odds ratios (ORs) and 95%CIs were estimated under the allelic, homozygous and heterozygous models. Sensitivity and subgroup analyses, by AMD subtype and ethnicity, were performed. Results: The meta-analysis included data of 27 418 AMD patients and 32 843 controls from 76 studies. In Caucasians, the rs1061170 showed a significant association with early AMD (OR: 1.44; 95%CI 1.27-1.63), dry AMD (OR: 2.90; 95%CI 1.89-4.47) and wet AMD (OR: 2.46; 95%CI 2.15-2.83), under an allelic model. In Asians, the rs1061170 showed a significant association with advanced AMD (OR: 2.09; 95%CI 1.67-2.60), especially wet AMD (OR: 2.24; 95%CI 1.81-2.77). Conclusion: Our work provides a more comprehensive meta-analysis of studies investigating the effect of the CFH rs1061170 polymorphism on AMD risk. These findings not only improve the assessment of disease risk associated with the polymorphism, but also constitute a scientific background to be translated into clinical practice for AMD prevention.

Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine

“…This finding was confirmed by pooled analysis in both Caucasians [ 95 ] and Asians [ 97 – 99 ]. A more recent meta-analysis stratified by stage of disease and ethnicity, including data of 27418 AMD patients and 32843 controls, stated that the polymorphism is significantly associated with AMD: in Caucasian the mutated allele confers a 1.44 risk of early AMD, a 2.90 risk of dry AMD and a 2.46 risk of wet AMD; in Asians, the mutated allele seems to be associated only with wet AMD [ 100 ].…”

Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation

“…The advanced stages may manifest as nonexudative or exudative AMD: the first is characterized by the geographic atrophy of RPE and thinning of the retina; the second is characterized by the development of choroidal neovascularization (CNV), which negatively affects central vision [ 3 , 4 ]. AMD is one of the most investigated multifactorial diseases since several sociodemographic (age and race) [ 5 ], environmental (cigarette smoking, light exposure, and nutrient intake) [ 6 , 7 , 8 , 9 , 10 ], and genetic risk factors [ 11 , 12 , 13 , 14 ] can act together, leading to a chronic condition of oxidative stress and inflammation [ 15 ].…”

Renin-Angiotensin System Inhibitor Usage and Age-Related Macular Degeneration among Hypertensive Patients: Results from the National Health and Nutrition Examination Survey, 2005–2008

“…The mechanisms of AMD are not completely established yet. Besides age [ 1 , 3 , 5 ], AMD is reported to be related to ethnicity [ 5 ], cigarette consuming [ 6 ], lower levels of antioxidants [ 7 ], less physical activity [ 8 ], systemic inflammation [ 9 ], genetic factors [ 10 , 11 ], etc. Apart from that, hypertension is also involved as a risk factor for AMD [ 5 , 12 ], multiplying the difficulties in developing efficient AMD treatment approaches for hypertensive patients.…”