The association between congenital cytomegalovirus infection and cerebral palsy: A systematic review and meta‐analysis

Ong, Leong Tung; Fan, Si Wei David

doi:10.1111/jpc.16244

Cited by 4 publications

(3 citation statements)

References 37 publications

(136 reference statements)

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“…Although, mortality due to cCMV is generally low [ 56 ]. The impact of cCMV as a leading non-genetic cause of SNHL [ 57 , 58 ] and an important cause of neurodevelopmental delay in children worldwide has been demonstrated to be substantial [ 59 – 61 ]. This facts were barely appreciated when looking at published survey data over the past 10–15 years.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus seronegativity rate in pregnant women and primary cytomegalovirus infection during pregnancy in rural Germany

Greye¹,

Wex²,

Taneva³

et al. 2023

BMC Pregnancy Childbirth

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Background Congenital cytomegalovirus (CMV) infection is the most common congenital infection worldwide and one of the leading causes of congenital hearing loss in newborns. The aim of this study was to determine the seroprevalence rate for cytomegalovirus in pregnant women and the rate of CMV serological testing utilised during pregnancy in a rural region in Germany. Methods Retrospective data on the prevalence of CMV IgG and IgM antibodies were obtained from 3,800 women, identified in the study group of 19,511 pregnant women from outpatient settings whose samples were collected between 1 and 2014 and 30 April 2018. In addition, the serological CMV status in regards to various billing methods was further analyzed. Results Serological CMV tests were performed in 3,800 (19.5%) out of 19,511 pregnant women. 2,081 (54.8%) of these women were CMV seronegative. Among those, seroconversion rate of 0.37–1.42% was identified. A proportion of 2,710 (14.7%) of all 18,460 women with statutory health insurance made use of the CMV testing as an individual health service. Conclusions The low uptake of CMV serological testing in the study population covered indicates low risk awareness among pregnant women and their healthcare professionals. Presented seronegativity rates and routine seroconversion rate, demonstrate importance to improve intervention strategy to prevent feto-maternal CMV transmission.

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus seronegativity rate in pregnant women and primary cytomegalovirus infection during pregnancy in rural Germany

Greye¹,

Wex²,

Taneva³

et al. 2023

BMC Pregnancy Childbirth

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“…Conversely, among patients with cerebral palsy, 10.9 percent had congenital HCMV. Moreover, congenital HCMV was associated with a worse form of cerebral palsy than that found in cerebral palsy patients without congenital HCMV [23,24]. Similarly, there is evidence that preterm children with early postnatal HCMV infection may differ from preterm children without infection on neuroimaging measures of structural and functional brain connectivity [25,26] and that preterm children who became infected with HCMV in the early postnatal period demonstrate cognitive impairment when evaluated as adolescents [27].…”

Section: Congenital Perinatal and Early-life Hcmv Infection And Child...mentioning

confidence: 97%

Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health

Gale,

Farrer,

Erbstoesser

et al. 2024

Pathogens

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A common infection, human cytomegalovirus (HCMV) has been associated with a variety of human diseases, including cardiovascular disease and possibly certain cancers. HCMV has also been associated with cognitive, psychiatric, and neurological conditions. Children with congenital or early-life HCMV are at risk for microcephaly, cerebral palsy, and sensorineural hearing loss, although in many cases sensorineural loss may resolve. In addition, HCMV can be associated with neurodevelopmental impairment, which may improve with time. In young, middle-aged, and older adults, HCMV has been adversely associated with cognitive function in some but not in all studies. Research has linked HCMV to Alzheimer’s and vascular dementia, but again not all findings consistently support these associations. In addition, HCMV has been associated with depressive disorder, bipolar disorder, anxiety, and autism-spectrum disorder, although the available findings are likewise inconsistent. Given associations between HCMV and a variety of neurocognitive and neuropsychiatric disorders, additional research investigating reasons for the considerable inconsistencies in the currently available findings is needed. Additional meta-analyses and more longitudinal studies are needed as well. Research into the effects of antiviral medication on cognitive and neurological outcomes and continued efforts in vaccine development have potential to lower the neurocognitive, neuropsychiatric, and neurological burden of HCMV infection.

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“…Some children in whom CP could be potentially prevented and most children with CP who live to adulthood need special support for the management of CP, and this is best when carried out by a multidisciplinary team. Improvement in emergency obstetric and postnatal care may reduce this burden [12][13][14][15][16][17][18][19] The most frequent clinical change in individuals with neurological impairment is epilepsy, affecting up to 90% of patients with CP, and up to a third of patients with CP experience seizures. The occurrence of neonatal seizures and genetic family history are useful markers for determining the cause of epilepsy in patients with CP.…”

Section: Introductionmentioning

confidence: 99%

Risk factor analysis of children and young people with cerebral palsy

Mascarin,

Costa,

Fregatto

et al. 2024

Preprint

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Currently, many individuals are affected by neurological disorders of various etiologies. In this study, we aimed to identify whether risk factors are associated with neurodevelopmental disorders in children and young people with cerebral palsy. We analyzed 258 medical records of people of both sexes with several neurological diagnoses. The analyzed data referred to demographic data, clinical data, and factors raised in neonatal anamnesis and neurodevelopmental disorders. The largest proportion of the sample is male, under 10 years of age, and is feeding orally. The risk factors were that the largest proportion underwent prenatal examination; had a cesarean section; and had low birth weight, hypoxia, and need for a neonatal intensive care unit. In relation to the neurodevelopmental disorder outcomes of interest, the largest proportion of the sample presented dysphagia, epilepsy, and gross motor function ≥ 4. We found that risk factors were not associated with neurodevelopmental disorders. However, the presence of hypoxia increases epilepsy risk.

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The association between congenital cytomegalovirus infection and cerebral palsy: A systematic review and meta‐analysis

Cited by 4 publications

References 37 publications

Cytomegalovirus seronegativity rate in pregnant women and primary cytomegalovirus infection during pregnancy in rural Germany

Cytomegalovirus seronegativity rate in pregnant women and primary cytomegalovirus infection during pregnancy in rural Germany

Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health

Risk factor analysis of children and young people with cerebral palsy

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