The association between CRP / Albumin ratio and in‐stent restenosis development in patients with ST‐segment elevation myocardial infarction

Aksu, Uğur; Gülcü, Oktay; Aksakal, Emrah; Kalkan, Kamuran; Öztürk, Mustafa; Korkmaz, Ali Fuat; Uslu, Abdülkadir; Demirelli, Selami

doi:10.1002/jcla.22848

Cited by 16 publications

(17 citation statements)

References 17 publications

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“…Likewise the ratio of fibrinogen to CRP has generated equivocal results [48][49][50] since it also varies in time due to the difference in expression time courses for the two proteins. Somewhat more success has been achieved using the ratio of CRP to albumin as a long-term outcome predictor in pancreatic cancer [51], surgery in the elderly [52], sepsis [53], and stent restenosis [54], while a similar 3-level index combining CRP and Alb measurements (the Glasgow Prognostic Score [55]; GPS) has achieved more widespread use as an outcome predictor in many cancers. The greater success of the CRP/Alb ratio and GPS may be attributed to the fact that the components move in opposite directions during the APR (being positive and negative APR respectively), so that inflammation-driven change of either protein from baseline drives the ratio upwards.…”

Section: Discussionmentioning

confidence: 99%

Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots

Anderson¹,

Razavi²,

Pope³

et al. 2019

Preprint

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High-frequency longitudinal tracking of inflammation using dried blood microsamples provides a new window for personalized monitoring of infections, chronic inflammatory disease, and clinical trials of anti-inflammatory drugs. Using 1,662 dried blood spot samples collected by 16 subjects over periods of weeks to years, we studied the behavior of 12 acute phase response (APR) and related proteins in inflammation events correlated with infection, vaccination, surgery, intense exercise and Crohn's disease. Proteins were measured using SISCAPA mass spectrometry and normalized to constant plasma volume using low-variance proteins, generating high precision within-person biomarker trajectories with well-characterized personal baselines. The results shed new light on the dynamic regulation of APR proteins and offer a new approach to visualization of multidimensional inflammation trajectories.

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Section: Discussionmentioning

confidence: 99%

Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots

Anderson¹,

Razavi²,

Pope³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…[20][21][22][23] During the 1 year follow up period, CAR is an independent predictor of stent restenosis in patients with STEMI. 24 Although CAR has been investigated in these various cardiovascular clinical settings, to the best of our knowledge, the predictive value of the CAR in POAF after CABG has not been evaluated. Therefore, this study aimed to investigate the predictive significance of CAR for POAF occurrence in patients who were underwent CABG surgery.…”

Section: Introductionmentioning

confidence: 99%

“…It is more valuable in the prediction of imperfect reperfusion, restenosis, acute renal injury, and contrast‐related nephropathy development after percutaneous coronary intervention than either CRP or albumin alone 20‐23 . During the 1 year follow up period, CAR is an independent predictor of stent restenosis in patients with STEMI 24 . Although CAR has been investigated in these various cardiovascular clinical settings, to the best of our knowledge, the predictive value of the CAR in POAF after CABG has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

The C‐reactive protein/albumin ratio as a new predictor for postoperative atrial fibrillation after coronary artery bypass graft surgery

et al. 2020

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Background This study aimed to investigate the predictive significance of C‐reactive protein/albumin ratio for postoperative atrial fibrillation occurrence in patients who were underwent coronary artery bypass graft surgery. Methods Among 830 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass between January 2016 and February 2020, 137 patients with no prior arrhythmia history were included in this cross sectional study. Results One hundred and thirty‐seven (16.5%) patients developed atrial fibrillation in postoperative period. Patients who experienced postoperative atrial fibrillation were more likely to be older but displayed similar rates of diabetes mellitus, hypertension, hypercholesterolemia, cerebrovascular disease, peripheral vascular disease and chronic obstructive pulmonary disease. For prediction of postoperative atrial fibrillation development, diagnostic odds ratio (OR) and positive likelihood ratio of C‐reactive protein/albumin ratio value (OR: 1.854; confidence interval [CI]: 1.598‐2.142; P < .001) was higher than serum C‐reactive protein and albumin levels. (OR: 1.159; CI: 1.115‐1.201; P < .001; OR: 0.438; CI: 0.258‐0.865; P < .001, respectively). Which means that C‐reactive protein/albumin ratio may detect postoperative atrial fibrillation development better C‐reactive protein itself. Conclusion Based on our results, patients who developed postoperative atrial fibrillation after coronary artery bypass grafting had significantly higher preoperative C‐reactive protein/albumin ratio levels than patients who remained in normal sinus rhythm in the postoperative period. Also, higher C‐reactive protein/albumin ratio value was one of the independent predictive factors for postoperative atrial fibrillation. Therefore, we concluded that evaluating preoperative C‐reactive protein/albumin ratio value might provide early identification of patients with high risk for postoperative atrial fibrillation.

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“…The multivariate linear regression showed an independent inverse association between CRP and albumin levels, suggesting that hypoalbuminemia in AB is associated with the acute inflammatory response. The association of low serum albumin levels with high concentrations of inflammatory markers such as CRP, or IL-6 has been previously demonstrated in adults [25][26][27] . Of note, among the inflammatory mediators that have been described to play an essential role in the Respiratory Syncytial Virus pathology are cytokines 6,28 .…”

Section: Discussionmentioning

confidence: 78%

Association of serum albumin levels with inflammation and clinical outcomes in children with acute bronchiolitis.

Rodríguez-González¹,

Rodríguez-Campoy²,

Estalella-Mendoza³

et al. 2020

Preprint

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Objective: To evaluate if hypoalbuminemia on admission predict disease severity in children with acute bronchiolitis (AB). Working hypothesis: Hypoalbuminemia is associated with worse outcome in infants with AB. Study design: Single-centre prospective cohort study. Patient-subject selection : Infants aged <12 month-old with AB. Methodology: Serum albumin levels were determined within the first 24 hours upon inclusion. The primary outcome was the need of pediatric intensive care unit (PICU) admission. Results: We enrolled 90 cases of AB. Serum albumin was independently associated with C-Reactive protein levels (CRP) (r s =-0,28; p=0.002). Fourteen (15.5%) cases required PICU admission. They presented lower serum albumin levels (3.7 (0.11) vs 4 (0.5) g/dl; p=0.034) regarding those patients without severe illness. In the multivariate logistic regression analysis, hypoalbuminemia was independently associated with a higher risk of severe illness (adjusted Odds Ratio 4.1 (1.2-85); p=0.032). The area under the ROC curve for serum albumin to predict adverse outcome was 0.70 (95% Confidence interval of 0.59-0.79). A cutoff point of 3.5 g/dl presented a sensitivity of 0.71, specificity of 0.68, positive predictive value of 0.29, and negative predictive value of 0.92. Conclusion:Low serum albumin levels at admission are significantly associated with higher PICU admission rates in infants with AB. The inflammatory response could play a key role in the occurrence of hypoalbuminemia in AB.

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The association between CRP / Albumin ratio and in‐stent restenosis development in patients with ST‐segment elevation myocardial infarction

Cited by 16 publications

References 17 publications

Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots

Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots

The C‐reactive protein/albumin ratio as a new predictor for postoperative atrial fibrillation after coronary artery bypass graft surgery

Association of serum albumin levels with inflammation and clinical outcomes in children with acute bronchiolitis.

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