The Association Between Curvature and Rupture in a Murine Model of Abdominal Aortic Aneurysm and Dissection

Lane, Brooks A.; Uline, Mark J.; Wang, X.; Shazly, Tarek; Vyavahare, Naren; Eberth, John F.

doi:10.1007/s11340-020-00661-x

Cited by 5 publications

(5 citation statements)

References 52 publications

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“…The univariate and multivariate logistic regression results indicate that the wall tension, WSS and curvature are all significant ones regarding to rupture regions. The consistency is found in Equations ( 8)- (11) with the results where WSS and tension are negatively correlated to the rupture, while curvature is positively correlated. From the perspective of mechanics (Equation 8), a unit decrease in tension results in the increase of rupture odd by 121 times (To be noticed, due to limited data, magnitudes of the odd coefficients are more representing propensity of rupture rather than quantify meanings), of which AUC is also up to 0.9750.…”

Section: Discussionsupporting

confidence: 77%

“…Conflict conclusion could be found in literature, such as both abnormally low and high wall shear stress (WSS) at aneurysm regions are found in IAs 5–8 . Some researchers have tried to utilize the geometric features of aneurysms and its parent arteries to explain the aneurysm rupture 9–11 . The peak value of first principal curvature is helpful in the prediction of abdominal aortic aneurysm (AAA) rupture in mice 10 .…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] Some researchers have tried to utilize the geometric features of aneurysms and its parent arteries to explain the aneurysm rupture. [9][10][11] The peak value of first principal curvature is helpful in the prediction of abdominal aortic aneurysm (AAA) rupture in mice. 10 The relationship between wall stress (or tension) and rupture has also been studied intensively in recent years, 12,13 and the localized degradation and weakening of the vascular wall are believed to be related to the rupture.…”

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confidence: 99%

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Association of local solid mechanical, hemodynamic and morphological characteristics with ruptured intracranial aneurysm

Zhai

Wang

et al. 2022

Numer Methods Biomed Eng

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The rupture of intracranial aneurysms (IAs) is a complicated phenomenon of which the mechanism is not fully understood. The purpose of this study is to associate local solid mechanical, hemodynamic, and morphological characteristics with rupture regions through statistical means, in an attempt to identify the parameters that are indicative of rupture propensity for IAs. Twenty patient‐specific ruptured IA models were reconstructed from digital subtraction angiography (DSA), and applied in the analysis of wall tension, wall shear stress (WSS) and curvature. The precise rupture locations were marked out through intraoperative videos. Pearson correlation analysis was employed to investigate the correlations of these three parameters with patient characteristics and global geometric features. Univariate and multivariate logistic regression analysis were further performed on wall tension, WSS and curvature with regards to rupture and nonrupture regions. Receiver operating characteristic (ROC) analysis defining area under the curve (AUC) was performed on these three parameters. The univariate model of wall tension (AUC, 0.9750), WSS (AUC, 0.9300), curvature (0.8150) and their combined multivariate model (AUC, 0.9875) all present high AUC values. The wall tension, WSS and curvature are acceptable parameters relating to rupture regions. The rupture odd is more sensitive to the wall tension and WSS than curvature. Each logistic model is capable in discriminating ruptures from nonrupture regions, while the multivariate model is the most efficient.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association of local solid mechanical, hemodynamic and morphological characteristics with ruptured intracranial aneurysm

Zhai

Wang

et al. 2022

Numer Methods Biomed Eng

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“…Despite the inherent complexity of Ang II-induced aneurysms, we used several convenient assumptions to study their mechanical and geometric properties, namely incompressibility, homogeneity, and axial symmetry. We acknowledge that additional metrics would be needed to comprehensively study aneurysmal mechanics, but these were omitted for the sake of simplicity and congruency with the biophysical, histological, and molecular aspects of this work 30 . Nevertheless, the defining feature of aortic aneurysms is the focal increase in diameter, and our PGG-treated tissues demonstrated a significant reduction in diameter compared to the aneurysmal CTRL group.…”

Section: Discussionmentioning

confidence: 99%

Systemic delivery of targeted nanotherapeutic reverses angiotensin II-induced abdominal aortic aneurysms in mice

Wang

Parasaram

Dhital

et al. 2021

Sci Rep

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Abdominal aortic aneurysm (AAA) disease causes dilation of the aorta, leading to aortic rupture and death if not treated early. It is the 14th leading cause of death in the U.S. and 10th leading cause of death in men over age 55, affecting thousands of patients. Despite the prevalence of AAA, no safe and efficient pharmacotherapies exist for patients. The deterioration of the elastic lamina in the aneurysmal wall is a consistent feature of AAAs, making it an ideal target for delivering drugs to the AAA site. In this research, we conjugated nanoparticles with an elastin antibody that only targets degraded elastin while sparing healthy elastin. After induction of aneurysm by 4-week infusion of angiotensin II (Ang II), two biweekly intravenous injections of pentagalloyl glucose (PGG)-loaded nanoparticles conjugated with elastin antibody delivered the drug to the aneurysm site. We show that targeted delivery of PGG could reverse the aortic dilation, ameliorate the inflammation, restore the elastic lamina, and improve the mechanical properties of the aorta at the AAA site. Therefore, simple iv therapy of PGG loaded nanoparticles can be an effective treatment option for early to middle stage aneurysms to reverse disease progression and return the aorta to normal homeostasis.

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“…In addition, a large number of studies used curvature as an independent indicator in their analyses [ 16 – 18 ]. Recent mouse AAA model studies have shown that mean and Gaussian curvatures are the key geometric parameters for determining rupture, respectively [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Combined Curvature and Wall Shear Stress Analysis of Abdominal Aortic Aneurysm: An Analysis of Rupture Risk Factors

Teng

Zhou

Zhao

et al. 2022

Cardiovasc Intervent Radiol

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Purpose To discuss the risk factors for abdominal aortic aneurysm rupture based on geometric and hemodynamic parameters. Methods We retrospectively reviewed the clinical data of those who were diagnosed with an abdominal aortic aneurysm by computed tomography angiography at our hospital between October 2019 and December 2020. Thirty-five patients were included in the ruptured group (13 patients) and the unruptured group (22 patients). We analyzed the differences and correlations of anatomical factors and hemodynamic parameters between the two groups using computational fluid dynamics based on computed tomography angiography. Results There were significant differences in the maximum diameter [(79.847 ± 10.067) mm vs. (52.320 ± 14.682) mm, P < 0.001], curvature [(0.139 ± 0.050) vs. 0.080 (0.123 − 0.068), P = 0.021], and wall shear stress at the site of maximal blood flow impact [0.549(0.839 − 0.492) Pa vs. (1.378 ± 0.255) Pa, P < 0.001] between the ruptured and unruptured groups, respectively. And in the ruptured group, wall shear stress at the rupture site was significantly different from that at the site of maximal blood flow impact [0.025 (0.049 − 0.018) Pa vs. 0.549 (0.839 − 0.492) Pa, P = 0.001]. Then, the maximum diameter and curvature were associated with rupture (maximum diameter: OR: 1.095, P = 0.003; curvature: OR: 1.142E + 10, P = 0.012). Most importantly, curvature is negatively correlated with wall shear stress (r = − 0.366, P = 0.033). Conclusions Both curvature and wall shear stress can evaluate the rupture risk of aneurysm. Also, curvature can be used as the geometric substitution of wall shear stress.

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The Association Between Curvature and Rupture in a Murine Model of Abdominal Aortic Aneurysm and Dissection

Cited by 5 publications

References 52 publications

Association of local solid mechanical, hemodynamic and morphological characteristics with ruptured intracranial aneurysm

Association of local solid mechanical, hemodynamic and morphological characteristics with ruptured intracranial aneurysm

Systemic delivery of targeted nanotherapeutic reverses angiotensin II-induced abdominal aortic aneurysms in mice

Combined Curvature and Wall Shear Stress Analysis of Abdominal Aortic Aneurysm: An Analysis of Rupture Risk Factors

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