The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction

Górski, Bartłomiej; Nargiełło, Ewa; Opolski, Grzegorz; Ganowicz, Ewa; Górska, Renata

doi:10.17219/acem/62937

Cited by 19 publications

(18 citation statements)

References 26 publications

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“…Górski et al, [20] also showed a positive association between oral local inflammatory processes and LDL level. Thus, preventive dental care is very important in systemic health [6].…”

Section: Discussionmentioning

confidence: 91%

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Relationship Between Body Mass Index, Lipid Profile and Dental Caries

Ahmadi‐Motamayel

Abdolsamadi

Goodarzi

et al. 2018

J Islam Dent Assoc Iran

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Background and Aim: Dental caries is the most common infectious, noncommunicable, chronic disease worldwide. Obesity and overweight are major public health problems. Both dental caries and obesity have multi-factorial etiology. The aim of the present study was to determine the possible correlation between the body mass index (BMI), lipid profile and dental caries in two groups of high-school students with active caries (AC) and no caries (CF) in Hamadan, Iran. Materials and Methods: In this case-control study, 118 high-school students between 15-19 years were divided into two groups of AC and CF. All clinical examinations were carried out by a single examiner. Blood samples were obtained from the antecubital vein. Lipid profile was assessed by the enzymatic method using an auto-analyzer. Data were analyzed using Stata.11 software. Statistical comparisons were made using Student's ttest and chi-square test. Results: BMI was significantly lower in AC group than CF group (P=0.008). Males had higher BMI than females (P=0.056). CF group had significantly lower level of triglycerides (P=0.01), cholesterol (P=0.02) and low-density lipoprotein (LDL) (P=0.02) than AC group. Conclusion: Our results showed that dental caries adversely affects the systemic growth pattern, and students with dental caries had lower BMI than others. Altered lipid profile had a higher frequency in AC group. Dental caries and obesity are both multi-factorial diseases; hence, well-designed epidemiologic studies on the same age group need to be performed in the future taking into account the socioeconomic and cultural factors.

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“…Górski et al, [20] also showed a positive association between oral local inflammatory processes and LDL level. Thus, preventive dental care is very important in systemic health [6].…”

Section: Discussionmentioning

confidence: 91%

“…They concluded that preventive dentistry is very important in general health. Many studies demonstrated the effect of local oral infection and preventive dentistry on systemic lipid profile, other inflammatory mediators and systemic health [6,19,20]. Studies have shown an association between DMFT, BMI and serum lipid profile [4,13].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Body Mass Index, Lipid Profile and Dental Caries

Ahmadi‐Motamayel

Abdolsamadi

Goodarzi

et al. 2018

J Islam Dent Assoc Iran

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“…Atherosclerosis is the main pathogenesis of myocardial infarction in coronary heart disease, which is affected by many factors, such as lipid metabolism disorder. Current researches indicated that dyslipidemia is one of the risk factors causing atherosclerosis, myocardial infarction and other vascular diseases (Cheng et al, 2015 ; Górski et al, 2016 ). On the basis of statin therapy in both treatment and control groups, the included studies indicated that TXL could effectively regulate lipid metabolism.…”

Section: Resultsmentioning

confidence: 99%

Potential Effectiveness of Chinese Patent Medicine Tongxinluo Capsule for Secondary Prevention After Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chen

et al. 2018

Front. Pharmacol.

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Background: Chinese patent medicine Tongxinluo capsule (TXL) is commonly used for cardio-cerebrovascular diseases. Previous research had demonstrated that TXL exhibited great clinical effects on the treatment of acute myocardial infarction (AMI), however there is a lack of systematic review. The purpose of this study was to evaluate the potential effectiveness and safety of TXL for secondary prevention in patients with AMI.Method: We searched 6 databases to identify relevant randomized controlled trials (RCTs) from inceptions to December 30, 2017. Two review authors independently assessed the methodological quality and analyzed data by the RevMan 5.3 software. The publication bias was assessed through funnel plot and Begg's test. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used for evaluating the quality of evidence.Results: We included 19 RCTs in this review and performed a meta-analysis based on 16 studies. There were statistical differences of TXL treatment group in reducing primary cardiovascular events (cardiac death [RR = 0.27, 95%CI: 0.08~0.95, I2 = 0%], recurrent myocardial reinfarction [RR = 0.38, 95%CI: 0.20~0.74, I2 = 0%], arrhythmia [RR = 0.44, 95%CI: 0.30~0.66, I2 = 0%], recurrent angina pectoris [RR = 0.34, 95%CI: 0.17~0.69, I2 = 0%]). TXL could improve cardiac function (LVEF [MD = 4.10, 95%CI: 3.95~4.25, I2 = 0%]), regulate blood lipid TC [MD = −0.66, 95%CI: −0.94 ~ −0.37, I2 = 74%], TG [MD = −0.38, 95%CI: −0.62 ~ −0.14, I2 = 70%], LDL-C[−0.40, 95%CI: −0.65 ~ −0.16, I2 = 88%), decrease the level of hs-CRP (4-week: MD = −0.78, 95%CI: −0.97 ~ −0.60, I2 = 20%; Over 4-week: MD = −1.36, 95%CI: −1.55 ~ −1.17, I2 = 20%). However, TXL has little effects on revascularization [RR = 0.45, 95%CI: 0.13~1.56, I2 = 0%], recurrent heart failure (RR = 0.83, 95%CI: 0.27~2.57, I2 = 0%), and HDL-C (MD = 0.14, 95%CI: 0.00 ~0.29, I2 = 73%). Furthermore, TXL treatment group was more prone to suffer gastrointestinal discomfort.Conclusion: Chinese patent medicine TXL seemed beneficial for secondary prevention after AMI. This potential benefit needs to be further assessed through more rigorous RCTs.Systematic review registration number in the PROSPERO register: CRD42017068417.

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“…A idade e o sexo são fatores de risco não modificáveis tanto para doenças periodontais como para doenças cardiovasculares 7 . A presente pesquisa apresentou maior incidência de doenças periodontais em pacientes idosos, assim como foi observado no estudo de Almeida et al 8 , e maior predileção de doenças para o sexo masculino, resultado encontrado por Goulart et al 9 , mas diferente de Almeida et al 8 , cujo estudo indicou que a maior incidência era em mulheres.…”

Section: Discussionunclassified

“…Há na literatura diversos estudos que investigam a possível associação entre as alterações ou doenças sistêmicas e a DP [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Alguns indicam associação positiva, enquanto outros afirmam não existir associação.…”

Section: Discussionunclassified

Associação entre condições sistêmicas e gravidade da doença periodontal em pacientes atendidos na Clínica-Escola da UFCG

Rodrigues

Medeiros

Sousa

et al. 2020

Rev. odontol. UNESP

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Resumo Introdução A doença periodontal é uma doença inflamatória crônica dos tecidos de proteção e suporte dos dentes. As doenças ou alterações de ordem sistêmica, como diabetes, alterações cardiovasculares e pulmonares, distúrbios hormonais e outras, não iniciam a doença periodontal, mas podem acelerar uma doença preexistente, aumentando sua progressão e destruição tecidual. Objetivo O presente estudo teve como objetivo avaliar, por meio de prontuários clínicos, uma possível associação entre as condições sistêmicas e a gravidade da doença periodontal em pacientes atendidos na Clínica-Escola de Odontologia da Universidade Federal de Campina Grande, campus CSTR (UFCG-CSTR). Material e método Para o estudo, foram avaliados 1.035 prontuários clínicos dos pacientes que procuraram atendimento na Clínica-Escola de Odontologia da UFCG-CSTR durante os anos de 2012 a 2017. Resultado A população estudada apresentou prevalência do sexo masculino (50,9%) e diagnóstico de doença gengival (63,6%) e periodontal (35,8%). As condições sistêmicas mais prevalentes foram hipertensão (15%), diabetes (7,5%) e cardiopatias (5,8%). Além disso, 20,2% relataram ser fumantes ou ex-fumantes, enquanto o uso de medicação foi observado em 28,3% dos casos. Foi verificada associação estatisticamente significativa entre doença periodontal, sexo masculino, faixa etária mais avançada, hipertensão arterial, tabagismo ou histórico de tabagismo e diabetes. Conclusão Foi observada uma quantidade de dentes igual ou menor do que 10 com maior frequência entre os pacientes com idade igual ou superior a 60 anos, hipertensos, diabéticos, cardiopatas e fumantes ou ex-fumantes, sugerindo, desse modo, uma maior gravidade da doença periodontal nesses indivíduos.

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The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction

Cited by 19 publications

References 26 publications

Relationship Between Body Mass Index, Lipid Profile and Dental Caries

Relationship Between Body Mass Index, Lipid Profile and Dental Caries

Potential Effectiveness of Chinese Patent Medicine Tongxinluo Capsule for Secondary Prevention After Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Associação entre condições sistêmicas e gravidade da doença periodontal em pacientes atendidos na Clínica-Escola da UFCG

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