The association between diabetes and depression: a very disabling condition

Fiore, Vittorio; Marci, Massimo; Poggi, Antonella; Giagulli, Vito Angelo; Licchelli, Brunella; Iacoviello, Massimo; Guastamacchia, Edoardo; Pergola, Giovanni De; Triggiani, Vincenzo

doi:10.1007/s12020-014-0323-x

Cited by 59 publications

(31 citation statements)

References 111 publications

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“…About 20–30% of elderly patients with diabetes suffer from clinical depression, and around 10% of them have major depression [ 22 ]. Even though the relationship between depression and diabetes is incompletely understood, it is clear that depression has an adverse impact on the course of diabetes, and diabetes complications may result in both the risk of depression and worsening the course of depression.…”

Section: Discussionmentioning

confidence: 99%

Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus

Wang

Yang

Nolan

et al. 2018

Cardiovasc Diabetol

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BackgroundDepression is a prevalent, independent predictor of mortality in patients with heart failure (HF). Depression is also common in type 2 diabetes mellitus (T2DM), which is itself an important risk factor for HF. However, association of depression with incident HF in T2DM is undefined. The aim of the present study was to evaluate the predictive value of depression in predicting incident HF in a community-based cohort of asymptomatic patients with T2DM.MethodsWe prospectively recruited 274 asymptomatic T2DM patients ≥ 65 years (age 71 ± 4 year, 56% men) with preserved EF and no ischemic heart disease from a community-based population. The Patient Health Questionnaire 9 (PHQ-9) was used to detect depression, and LV dysfunction was sought with a comprehensive echocardiogram, including LV hypertrophy (LVH) and subclinical diastolic function (E/e′). Over a median follow-up of 1.5 years (range 0.5–3), 20 patients were lost to follow-up and 254 individuals were followed for outcomes.ResultsAt baseline, depression was present in 9.5%, LVH was identified in 26% and reduced E/e′ in 11%. Over a median follow-up of 1.5 years, 37 of 245 patients developed new-onset HF and 3 died, giving an event rate of 107/1000 person-years. In a competing-risks regression analysis, depression (adjusted HR 2.54, 95% CI 1.18–5.46; p = 0.017) was associated with incident HF and had incremental predictive power to clinical, biochemical and echocardiographic variables.ConclusionDepression is prevalent in asymptomatic elderly patients with T2DM, and depression independently and incrementally predicts incident HF.

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Section: Discussionmentioning

confidence: 99%

Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus

Wang

Yang

Nolan

et al. 2018

Cardiovasc Diabetol

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“…People with unipolar or bipolar affective disorders are more prone to develop diabetes mellitus and vascular disease. On the other hand, adiposity and diabetes are associated with an increased risk for depressive mood changes, possibly associated with chronic low-grade inflammation [24,25]. In this context, sICAM-1 elevation might be a common pathogenetic factor for mood disorders and mood changes during metabolic disorders, diabetes, chronic low-grade inflammation as well as vascular complications, and would also support the hypothesis of a subclinical increased permeability of the BBB [26].…”

Section: Discussionmentioning

confidence: 99%

Soluble Intracellular Adhesion Molecule-1 in Patients with Unipolar or Bipolar Affective Disorders: Results from a Pilot Trial

et al. 2016

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Background: Immunological and vascular markers may play a role in the pathophysiology of mood disorders and mood changes. Aim: To test whether the cell adhesion molecule soluble intracellular adhesion molecule-1 (sICAM-1) may serve as a biomarker for patients with unipolar or bipolar affective disorders when compared to a healthy control group, and whether sICAM-1 blood levels change during different mood states. Methods: sICAM-1 serum concentrations were compared between 20 healthy controls and 48 patients with affective disorders (unipolar, bipolar II and bipolar I disorder) during different mood states (euthymic mood state, depression or mania). Results: When compared to healthy controls, patients with affective disorders had significantly higher sICAM-1 levels during the euthymic state (p = 0.015). Differences became more pronounced during depression (p = 0.013). When unipolar and bipolar patients were analyzed separately, unipolar patients significantly differed from controls during the euthymic and depressive mood state, while bipolar II patients showed a trend towards higher sICAM-1 levels during depression. Patients with bipolar I disorders had significantly higher sICAM-1 levels during manic states when compared to controls (p = 0.007). Conclusions: sICAM-1 elevation in unipolar and bipolar patients, independent of mood changes, might support the hypothesis of chronic immune activation and endothelial dysfunction in patients with affective disorders.

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“…The prevalence of depression in patients with diabetes has been widely reported (Katon, 2008). Rates of depression are significantly enhanced in diabetic patients: near 20-30% of diabetes patients suffered from clinically relevant depressive disorders (Fiore et al, 2015), and the risk of depression remains elevated over time in some type 2 diabetes patients (Whitworth et al, 2017). The metabolic dysfunction of obesity contributes to the development of depression (Carmo-Silva and Cavadas, 2017), and the interaction between depressive symptoms and metabolic dysfunction may be a risk factor for type 2 diabetes (Schmitz et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

et al. 2020

Front. Pharmacol.

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The comorbidity of diabetes and depression has a negative impact on both lifestyle and quality of life. Astaxanthin (AST) has been demonstrated to improve glucose metabolism and has antidepressant-like effects, but it is not clear whether AST has potential for preventing depression in diabetes. The aim of this study is to observe the preventive and therapeutic effects of AST on glucose metabolism or depressive-like behaviors in a diabetic rat model produced by feeding with a high-fat diet for 10 weeks followed by injection of 25 mg/kg streptozotocin (STZ). Preventive treatment with AST at doses of 7.5, 15, and 25 mg/kg/day was given by intragastric gavage 4 weeks before STZ injection. Preventive plus therapeutic treatment also involved therapeutic AST treatments for 6 more weeks after STZ injection, whereas therapeutic-only treatment involved only the 6-week post-STZ treatment. Depressive-like behaviors were evaluated at the end of the treatment by using open field, locomotor activity, elevated plus maze, and forced swimming tests. Preventive and therapeutic treatment with AST both reduced the level of fasting glucose, improved glucose tolerance, and decreased total TCh and TG in diabetic rats. Preventive or preventative plus therapeutic treatment with AST decreased the immobility time and increased the time spent in the open arms of an elevated plus maze and locomotor activity in diabetic rats. However, therapeutic treatment with AST alone failed to affect the depressive-like behaviors. Preventive or preventative plus therapeutic treatment with AST at doses of 15 or 25 mg/kg significantly increased the expression of pERK, pAKT, pCREB, and BDNF in the prefrontal cortex (PFC) in diabetic rats. In contrast, therapeutic treatment with 25 mg/kg AST alone increased the expression of pERK in the PFC. This study indicates that AST may be used as a preventive or therapeutic approach for comorbidity of diabetes and depression.

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The association between diabetes and depression: a very disabling condition

Cited by 59 publications

References 111 publications

Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus

Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus

Soluble Intracellular Adhesion Molecule-1 in Patients with Unipolar or Bipolar Affective Disorders: Results from a Pilot Trial

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

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