The association between dietary acid load and body composition in physical education students aged 18–25 years

Mansordehghan, Maryam; Daneshzad, Elnaz; Basirat, Vahid; Gargari, Bahram Pourghassem; Rouzitalab, Tohid

doi:10.1186/s41043-022-00340-8

Cited by 5 publications

(4 citation statements)

References 44 publications

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“…As a consequence, females are more sensitive to the effects of diet-dependent acid load (55) . Furthermore, NEAP was observed to have a significant positive association with fat mass in females but not males (56) . Notably, body fatness was indicated to be related to CRC in females (57) .…”

Section: Discussionmentioning

confidence: 96%

The association of diet-dependent acid load with colorectal cancer risk: a case–control study in Korea

Tran,

Gunathilake,

Lee

et al. 2023

Br J Nutr

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Acid‒base disequilibrium is a contributor to cancer development because it affects molecular activities such as insulin-like growth factor 1 levels and adiponectin production. However, evidence of an association of diet-induced acid‒base imbalance with colorectal cancer (CRC) is limited. We examined whether colorectal carcinogenesis is attributable to a diet with a high acid load. We recruited a total of 923 CRC cases and 1846 controls at the National Cancer Center in Korea for inclusion in a case–control study. We collected information on nutrient intake and specific clinical parameters of CRC by using a semiquantitative food frequency questionnaire and medical records, respectively. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) were used to estimate diet-dependent acid load. We used an unconditional logistic regression model to analyse the association. Dietary acid load scores had a positive association with the odds of CRC risk (odds ratio (OR)= 2.31 (95% confidence interval (CI): 1.79-2.99) and OR=2.14 (95% CI: 1.66-2.76) for PRAL and NEAP, respectively, P for trends<0.001). A stronger positive association was observed for females (OR=3.09, 95% CI: 1.93-4.94) than for males (OR=1.71, 95% CI: 1.27-2.31). Furthermore, acidogenic diets appeared to affect rectal cancer more strongly than colon cancer in females. Our study contributes to reinforcing epidemiological evidence regarding a detrimental effect of acidogenic diets on colorectal carcinogenesis. Thus, it is important to pay attention to the balance of acidogenic (e.g., poultry and red meat) and alkalinogenic foods (e.g., fruits and vegetables) in CRC prevention, especially for females.

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Section: Discussionmentioning

confidence: 96%

The association of diet-dependent acid load with colorectal cancer risk: a case–control study in Korea

Tran,

Gunathilake,

Lee

et al. 2023

Br J Nutr

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“…Another possible mechanism which may explain the inverse association between DAL and ovarian reserve markers is the potential effect of diet-induced acidosis on increased adiposity. Several previous studies demonstrated the relationship between DAL and obesity measures [ 37 , 38 ]. A 16-week randomized clinical trial on the effect of a plant-based diet with low DAL on body composition and insulin sensitivity on adults with overweight reported a greater reduction in body weight mainly due to a reduction in fat mass and visceral fat in participants on a low DAL diet compared to control group [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary acid load and risk of diminished ovarian reserve: a case-control study

Ziaei,

Ghavami,

Ghasemi-Tehrani

et al. 2024

Reprod Biol Endocrinol

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Background The epidemiologic evidence on the association between acid load potential of diet and the risk of diminished ovarian reserve (DOR) is scarce. We aim to explore the possible relationship between dietary acid load (DAL), markers of ovarian reserve and DOR risk in a case-control study. Methods 370 women (120 women with DOR and 250 women with normal ovarian reserve as controls), matched by age and BMI, were recruited. Dietary intake was obtained using a validated 80-item semi-quantitative food frequency questionnaire (FFQ). The DAL scores including the potential renal acid load (PRAL) and net endogenous acid production (NEAP) were calculated based on nutrients intake. NEAP and PRAL scores were categorized by quartiles based on the distribution of controls. Antral follicle count (AFC), serum antimullerian hormone (AMH) and anthropometric indices were measured. Logistic regression models were used to estimate multivariable odds ratio (OR) of DOR across quartiles of NEAP and PRAL scores. Results Following increase in PRAL and NEAP scores, serum AMH significantly decreased in women with DOR. Also, AFC count had a significant decrease following increase in PRAL score (P = 0.045). After adjustment for multiple confounding variables, participants in the top quartile of PRAL had increased OR for DOR (OR: 1.26; 95%CI: 1.08–1.42, P = 0.254). Conclusion Diets with high acid-forming potential may negatively affect ovarian reserve in women with DOR. Also, high DAL may increase the risk of DOR. The association between DAL and markers of ovarian reserve should be explored in prospective studies and clinical trials.

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“…In addition to BMI, several studies report a positive association between high DAL and various other anthropometric measurements. These include an increased waist-to-height ratio, larger hip and neck circumference, a higher fat mass, and lower fat-free mass [ 11 , 96 , 141 , 142 ]. Moreover, a study involving 3018 individuals aged 60 years and older from the USA identified that a high DAL is not only positively correlated with BMI but also with sagittal abdominal diameter [ 142 ].…”

Section: Dietary Acid Load In Metabolic Disordersmentioning

confidence: 99%

Dietary acid load in health and disease

Wieërs,

Beynon-Cobb,

Visser

et al. 2024

Pflugers Arch - Eur J Physiol

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Maintaining an appropriate acid–base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and magnesium, and the organic acids from foods, which are metabolized to bicarbonate and thus have an alkalinizing effect. Current Western diets are characterized by a high DAL, due to large amounts of animal protein and processed foods. A chronic low-grade metabolic acidosis can occur following a Western diet and is associated with increased morbidity and mortality. Nutritional advice focusing on DAL, rather than macronutrients, is gaining rapid attention as it provides a more holistic approach to managing health. However, current evidence for the role of DAL is mainly associative, and underlying mechanisms are poorly understood. This review focusses on the role of DAL in multiple conditions such as obesity, cardiovascular health, impaired kidney function, and cancer.

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The association between dietary acid load and body composition in physical education students aged 18–25 years

Cited by 5 publications

References 44 publications

The association of diet-dependent acid load with colorectal cancer risk: a case–control study in Korea

The association of diet-dependent acid load with colorectal cancer risk: a case–control study in Korea

Dietary acid load and risk of diminished ovarian reserve: a case-control study

Dietary acid load in health and disease

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