The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys

Abstract

Objective To investigate the associations of dietary inflammation index (DII) with bone density and osteoporosis in different femoral areas. Methods The study population was selected from the National Health and Nutrition Examination Survey (NHANES) with the exclusion criteria of age 18, pregnancy, or missing information on DII, femoral bone marrow density (BMD), estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio (UACR), or had diseases which may influence systemic inflammation. DII was calculated based on the questionnaire interview of dietary recall within 24 h. Subjects’ baseline characteristics were collected. The associations between DII and different femoral areas were analyzed. Results After applying exclusion criteria, 10,312 participants were included in the study. Significant differences among DII tertiles were found in BMD or T scores ( p < .001) of the femoral neck, the trochanter, the intertrochanter, and the total femur. High DII was associated with low BMDs and T scores in all the femoral areas (all p < .01). Compared to low DII (tertile1, DII < 0.380 as reference), in the femoral neck, the intertrochanter, and the total femur, increased DII is independently associated with increased the possibility of the presence of osteoporosis (OR, 95% CI: 1.88, 1.11–3.20; 2.10, 1.05–4.20; 1.94, 1.02–3.69, respectively). However, this positive association was only observed in the trochanteric area of the non-Hispanic White population after full adjustment (OR, 95% CI: 3.22 (1.18, 8.79)). No significant difference in the association of DII and the presence of osteoporosis were found in subjects with or without impaired kidney function (eGFR < 60 ml/min/1.73 m 2 ). Conclusion High DII is independently related to declined femoral BMD of femoral areas.

Association between different composite dietary antioxidant indexes and constipation in American male adults: a cross-sectional study

“…The CDAI serves as a tool to quantify the potential antioxidant capacity of one’s daily diet ( 21 ). Existing literature suggests that CDAI is negatively correlated with osteoporosis ( 22 ), hypertension ( 23 ), depression ( 20 ), and cardiovascular disease mortality ( 24 ). Furthermore, it is also associated with specific inflammatory biomarkers such as IL-1β and TNFα ( 25 ), which are known to be elevated in constipated populations ( 26 ).…”

Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics

“…The Canadian Multicenter Osteoporosis Study showed that an increased intake of protein and nutrient-dense foods, such as fruits, vegetables, and whole grains, was associated with a lower fracture risk [68]. Similar trends were seen in different diets among different cultures.…”

The association between bone density of lumbar spines and different daily protein intake in different renal function

“…CKD patients with HPI do not benefit from developing higher femoral BMD, and those with LDI do not develop lower femoral BMD. However, in a previously published study [ 55 ], it was found that a high dietary inflammation index is independently associated with decreased bone mineral density (BMD) in the femoral regions. In the present study, we found similar results regarding lumbar BMD in the NHANES cohort.…”