The association between dietary intake of flavonoids and its subclasses and the risk of metabolic syndrome

Abstract

BackgroundThe healthiest way to prevent metabolic syndrome (MetS) is through behavioral and nutritional adjustments. We examined the relationship between total flavonoids intake, flavonoid subclasses, and clinically manifest MetS.MethodsA cross-sectional analysis was conducted among 28,719 individuals from the National Health and Nutrition Examination Survey (NHANES) and Food and Nutrient Database for Dietary Studies (FNDDS) 2007–2011 and 2017–2018. Two 24-h reviews were conducted to determine flavonoids intake and subclasses. The link between flavonoids intake and MetS was investigated using a multivariate logistic regression model.ResultsQ2 and Q3 of total flavonoids intake were associated with 20 and 19% lower risk of incident MetS after adjusting age and sex. Anthocyanidins and flavanones intake in Q2 and Q3 substantially reduced the MetS risk compared to Q1. MetS risk decreased steadily as the total intake of flavonoids increased to 237.67 mg/d. Flavanones and anthocyanidins also displayed V-shaped relationship curves (34.37 and 23.13 mg/d).ConclusionMetS was adversely linked with total flavonoids intake, flavanones, and anthocyanidins. Moreover, the most effective doses of total flavonoids, flavanones, and anthocyanidins were 237.67, 34.37, and 23.13 mg/d, respectively, potentially preventing MetS.

Association between consumption of flavonol and its subclasses and chronic kidney disease in US adults: an analysis based on National Health and Nutrition Examination Survey data from 2007–2008, 2009–2010, and 2017–2018

“…The determination of daily nutrient intake from food sources was achieved through a complex methodology ( 16 , 17 , 30 ). Briefly, this segment of data collection was organized under the auspices of the US Department of Agriculture (USDA).…”

“…To accurately match foods containing flavonol and determine their flavonol content, food codes from the Food and Nutrient Database for Dietary Studies (FNDDS) were used. Specifically, the NHANES 2007–2008 dataset used FNDDS version 4.1 food codes, whereas the NHANES 2009–2010 and 2017–2018 datasets used FNDDS version 5.0 food codes ( 16 , 17 , 30 ). In this study, the aggregate flavonol intake during Day 1 and Day 2 was use as a metric to measure the flavonol consumption of each participant.…”

“…These compounds display a diverse range of biological activities including antioxidant, anti-inflammatory, antifibrotic, and immunomodulatory, all of which appear to contribute to improved health outcomes (6)(7)(8)(9). Evidence suggests that high flavonol consumption may confer benefits to patients suffering from cardiovascular diseases (10,11), neurodegenerative disorders (12,13), diabetes (14), hyperlipidemia (15), metabolic syndrome (16,17), and those in a debilitating state (18). Preliminary research indicates that flavanol and its subclasses can protect the kidneys through various mechanisms (19)(20)(21)(22)(23).…”

Dietary anthocyanin is associated with a lower prevalence of hyperuricemia independently of metabolic syndrome among females: Results from NHANES 2007–2010 and 2017–2018

“…Previous publications from NHANES have reported associations between anthocyanin and hyperuricemia, as well as associations between anthocyanin and MetS. 23,24 However, none of these studies have examined the complex relationship between hyperuricemia and MetS. Given the limited clinical evidence and the close connection between hyperuricemia and MetS, we raised the question that whether flavonoid can independently serve as a protective factor for hyperuricemia, regardless of its association with MetS.…”

“…Because of anti‐inflammatory, antioxidant, and estrogenic properties, 20–22 anthocyanin has attracted the interest of researchers in the field of metabolic diseases. Previous publications from NHANES have reported associations between anthocyanin and hyperuricemia, as well as associations between anthocyanin and MetS 23,24 . However, none of these studies have examined the complex relationship between hyperuricemia and MetS.…”