The association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of china

Feng, Chang-Yan; Lin, Margaret J.; Lakhaney, Divya; Sun, Haikui; Dai, Xing-bi; Zhao, Fanghui; Qiao, You‐Lin

doi:10.1007/s00404-010-1743-3

Cited by 13 publications

(12 citation statements)

References 16 publications

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“…However, whether such factors differ by region has rarely been investigated. Diet, which is a region-associated factor and includes parameters such as mineral intake, has recently been reported to be associated with the risk of CIN [10]- [11] . The intake of magnesium, calcium, and zinc is essential for maintaining the integrity of DNA and preventing oxidative DNA damage [12][13][14] ; as such, intake deficiency of these minerals can trigger cancer development.…”

Section: Ivyspringmentioning

confidence: 99%

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Wang

Yang

et al. 2021

J. Cancer

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Population-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) or cervical cancer in Chinese women are few. We performed a cross-sectional analysis of screening data obtained from 2,304 women in 2014 within an ongoing cohort study comprising 40,000 women in China. Dietary intake was assessed using a semiquantitative food frequency questionnaire. Nutrition intake was calculated using a 26-item list of food sources drawn from a validated, comprehensive database. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. The Pearson chi-square test was used for categorical variables. Multivariable logistic regression models were used to evaluate the relationship between dietary mineral intake and CIN+ risk. The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple potential confounders, low dietary calcium intake was associated with CIN2+ risk (first versus fourth quartile: odds ratio [OR]=1.52, 95% confidence interval [CI]: 1.01-2.32). Similar for magnesium (OR=1.80, 95% CI: 1.20-2.68), phosphorus (OR=1.69, 95% CI: 1.12-2.55), zinc (OR=1.55, 95% CI: 1.03-2.34), and potassium (OR=1.92, 95% CI: 1.28-2.88). Low dietary intakes of calcium and potassium were significantly associated with CIN1 risk. Increased CIN2+ risk correlated with rates of no oral contraceptives and lower levels of dietary Potassium. These results thus proposed that low dietary mineral intake was an independent risk factor, potential synergy may exist between low dietary mineral levels and oral contraceptives contribute to the development of higher-grade CIN and cervical cancer.

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Section: Ivyspringmentioning

confidence: 99%

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Wang

Yang

et al. 2021

J. Cancer

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“…In cross-sectional population-based cervical cancer screening studies in China, the comparison of the lowest and highest tertiles regarding the consumption of onion-related vegetables and legumes yielded AORs of 0.589 (95% CI, 0.387–0.897, p = 0.011) and 0.591 (95% CI, 0.392–0.892, p = 0.012), respectively, for the risk of CIN 2 among 748 HPV-positive women [ 64 ]. Hwang et al evaluated the relationship between the dietary intake of vegetables and the risk of CIN and investigated whether or not these associations were modified by the HPV viral load [ 65 ].…”

Section: Foodsmentioning

confidence: 99%

The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development

et al. 2020

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Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail.

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“…A study by Feng et al 32 Hwang et al 33 analyzed a cohort with a 3-year followup, to determine the relationship between the intake of fruits and vegetables and the development of cervical dysplasia (CIN1, CIN2, and CIN3) in HPV+ and HPV-subjects. Fruit consumption of < 109 g/day (OR = 2.93; 95% CI = 1.25-6.87; p = 0.01) and vegetable consumption of < 302 g/day (OR = 2.84; 95% CI = 1.26-6.42; p = 0.06) were found to be associated with CIN2 and CIN3 in HPV+ subjects.…”

Section: Role Of Foods and Nutrients In The Control And Elimination Omentioning

confidence: 99%

Immunonutrition in Cervical Cancer: Immune Response Modulation by Diet

Medina-Contreras¹,

Luvian-Morales²,

Valdez-Palomares³

et al. 2020

RIC

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In the development of cervical cancer (CC), the immune response plays an essential role, from the elimination of human papillomavirus (HPV) infection to the response against the tumor. For optimal function of the immune response, various factors are required, one of the most important being an adequate nutrition. The complex interaction between nutrients and microbiota maintains the immune system in homeostasis and in case of infection, it provides the ability to fight against pathogen invasion, as occurs in HPV infection. The purpose of this article is to describe the role of diet, food, and specific nutrients in the immune response from the onset of infection to progression to precancerous lesions and CC, as well as the role of diet and nutrition during oncological treatment. The immunomodulatory role of microbiota is also discussed. A detailed analysis of the evidence leads us to recommend a nutritional pattern very similar to the Mediterranean diet or the prudent diet for an optimal immune response. Moreover, pre-and probiotics favorably modulate the microbiota and induce preventive and therapeutic effects against cancer.

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The association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of china

Abstract: Dietary intake of onion vegetables, legumes, nuts, and meat is associated with reduced risk of CIN2+. These foods may provide a protective factor against CIN2+.

Cited by 13 publications

References 16 publications

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development

Immunonutrition in Cervical Cancer: Immune Response Modulation by Diet

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