The association between dietary patterns and depression in adolescents: A cross-sectional study

Hemmati, Amirhossein; Ghoreishy, Seyed Mojtaba; Karami, Keianoush; Imani, Hossein; Farsani, Gholamreza Mohammadi; Mousavi, Sara Ebrahimi; Asoudeh, Farzaneh; Shariati-Bafghi, Seyedeh-Elaheh; Karamati, Mohsen

doi:10.1016/j.clnesp.2021.09.743

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…Recent evidence from epidemiological, clinical, and animal studies indicates that HFD consumption is associated with a high incidence of depression and anxiety [ 6 , 7 , 35 , 36 , 37 , 38 ]. Considering the increasing healthcare burden imposed by adolescent depression/anxiety [ 39 , 40 ] and the prevalence of HFD consumption among adolescents, it is imperative to explore the relationship between HFD consumption in adolescence and emotional disorders as well as the underlying neurobiological mechanism in animal models.…”

Section: Discussionmentioning

confidence: 99%

High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation

Yao

Yang

Wang

et al. 2022

IJMS

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Adolescence is a developmental epoch characterized by massive neural circuit remodeling; thus, the brain is particularly vulnerable to environmental influences during this period. Excessive high-fat diet (HFD) consumption, which is very common among adolescents, has long been recognized as a potent risk factor for multiple mood disorders, including depression and anxiety. However, the precise mechanisms underlying the influences of HFD consumption in adolescence on emotional health are far from clear. In the present study, C57BL/6 mice were fed a control diet (CD) or HFD for about 4 weeks from postnatal day (P) 28 to P60, spanning most of the adolescence period, and then subjected to behavioral assessments and histological examinations. HFD mice exhibited elevated levels of depression and anxiety, decreased hippocampal neurogenesis, and excessive microglial activation in the ventral hippocampus. Furthermore, in HFD-fed mice, microglia showed increased DCX+ inclusions, suggesting aberrant microglial engulfment of newborn neurons in HFD-fed adolescents. To our knowledge, this is the first observation suggesting that the negative effects of HFD consumption in adolescence on emotion and neuroplasticity may be attributed at least in part to aberrant microglial engulfment of nascent neurons, extending our understanding of the mechanism underlying HFD-related affective disorders in young people.

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Section: Discussionmentioning

confidence: 99%

High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation

Yao

Yang

Wang

et al. 2022

IJMS

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“…Despite earlier mixed findings (Chocano-Bedoya et al, 2013;Gougeon et al, 2015;Okubo et al, 2011), there is growing evidence suggesting that UDP is associated with an increased risk of depression (Oddy et al, 2018;Ruusunen et al, 2014). Specifically, an UDP characterized by high consumption of sweets, fatty foods and high-fat dairy has been implicated (Hemmati et al, 2021;Li et al, 2017). This type of diet may lead to alteration in endorphin levels, and elevated risk of cardiovascular diseases and brain atrophy, as well as increased levels of oxidative stress and inflammation (Lopez-Garcia et al, 2004;Marx et al, 2020;Westover and Marangell, 2002).…”

Section: Potential Pathways Linking Street Network Metrics To the Sym...mentioning

confidence: 99%

Pathways from street network design to symptoms of depression among emerging adults in China

Cui

Wen

Yang

et al. 2023

Travel Behaviour and Society

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“…Research confirms that in children and adolescents, greater adherence to MD is associated with a better academic performance, while WD at 14 is associated with poorer cognitive outcomes at 17 years of age [ 68 ]. A Western style of eating characterized by high consumption of fries, hydrogenated fats, mayonnaise, sweets, desserts, high-fat dairy products, refined grains, red or processed meats, pickles, offal and soft drinks, and low consumption of low-fat dairy products was positively correlated with depression scores among adolescents [ 69 ]. There are several reports showing that neurochemistry and brain function may be influenced by saturated fatty acids (SFAs).…”

Section: Analysis Of Eating Behavior/patterns In the Context Of The M...mentioning

confidence: 99%

The Mediterranean Diet and the Western Diet in Adolescent Depression-Current Reports

et al. 2022

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Depression is one of the most common mental disorders in the world and a current and growing social and health problem. The growing scale of the problem not only concerns adults, but now it particularly affects children and adolescents. Prevention, early diagnosis and treatment of mood disorders in adolescence is crucial because adolescent depression is a risk factor for recurrence of depression later in life, as well as many other mental health disorders in adulthood. The purpose of this study was to analyze data on the dietary patterns and composition of the Mediterranean diet as a modifiable risk factor for depression, which would be a viable prevention strategy and a good target for early intervention and supportive treatment of depression. Research shows that the Mediterranean diet pattern can reduce the risk and symptoms of depression, while western eating styles can increase the risk and severity of depression in adolescents. The number of studies in adolescent populations continues to increase, but most longitudinal and clinical studies are still insufficient. Modification of the diet can be a helpful strategy for the prevention and treatment of depression in adolescents; therefore, the diet of young people should be considered a key and modifiable goal in the prevention of mental disorders.

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The association between dietary patterns and depression in adolescents: A cross-sectional study

Cited by 10 publications

References 27 publications

High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation

High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation

Pathways from street network design to symptoms of depression among emerging adults in China

The Mediterranean Diet and the Western Diet in Adolescent Depression-Current Reports

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