The Association Between DRD2/ANKK1 TaqIA Polymorphism and Impulsivity in Patients With Opioid Dependence Disorder

Enaba, Dalia; Magd, Samir F. Abou el; Baz, Heba; Hegazy, Nesma

doi:10.1097/adt.0000000000000148

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…This has created an urgent need to understand the neurotoxic consequences of substance use to develop targeted treatments to minimize and/or reverse the damage induced by these drugs. While the mechanisms leading to substance use and addiction are multifactorial 3 and likely involve environmental 3, 4 , genetic 5, 6 , and socioeconomic factors 7, 8 , examining how different substances lead to protein changes in the brain can provide some insight into the underlying biological mechanisms of neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Alcohol, Opioid, and Combined Alcohol and Opioid Use Disorders Affect Shared and Unique Pathways: A Proteomic Analysis of Postmortem Brains

Leung

Stertz

Teixeria

et al. 2022

Preprint

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Substance misuse is a major burden for not only patients but the healthcare system. Understanding how substance misuse alters a patient's genome, proteome, and neurocircuitry is an important step toward identifying targets for treatments. In this exploratory study, we performed a proteomic analysis of postmortem brain from individuals with substance misuse disorder (n=29), including alcohol (n=11) and opioid misuse disorder (n=12), or comorbidity with both disorders (n=6), compared to controls (n=12). The results demonstrate that these substances affect both common and different biological pathways compared to controls. Alcohol misuse affects primarily protein translation, rRNA processing, and energy metabolism pathways, while opioid influences G-protein signaling, protein translation, rRNA processing, energy metabolism, and angiogenesis pathways. Alcohol and opioid misuse combined appears to have a synergistic effect on protein expression of the TCA cycle, respiratory transport, mitochondrial function, LGI-ADAM interactions, interleukin signaling, neuronal system changes, and actin polymerization. These findings offer new insights into how substance misuse leads to protein alterations and how combined substance misuse leads to different protein changes compared to single substance misuse.

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