2022
DOI: 10.3389/fpsyt.2021.802302
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The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19

Abstract: Objective: This study aimed to investigate the relationship between dry eye disease (DED) with anxiety and depression. Additionally, the mediating effect of sleep quality on this relationship was explored.Methods: 321 patients with DED were recruited from Tianjin Medical University Eye Hospital clinic and surveyed using demographic questionnaires, the Ocular Surface Disease Index (OSDI), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI). Regression analysis and the bootstr… Show more

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Cited by 9 publications
(10 citation statements)
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“…For these reasons, anxiety and depression may lead to a decreased pain threshold and an increased sensitivity to physical sensations (39)(40)(41)(42). Studies have indicated that somatization is present in most anxiety and depression patients, which may play a role in exacerbating DED symptoms (43,44). Increased levels of inflammatory cytokines in blood and tears of patients with anxiety and depression will lead to the activation of the brain cytokine system (45)(46)(47).…”
Section: Discussionmentioning
confidence: 99%
“…For these reasons, anxiety and depression may lead to a decreased pain threshold and an increased sensitivity to physical sensations (39)(40)(41)(42). Studies have indicated that somatization is present in most anxiety and depression patients, which may play a role in exacerbating DED symptoms (43,44). Increased levels of inflammatory cytokines in blood and tears of patients with anxiety and depression will lead to the activation of the brain cytokine system (45)(46)(47).…”
Section: Discussionmentioning
confidence: 99%
“…BUT and corneal staining are parameters of corneal epithelial cells and precorneal tear film, while strip meniscometry is that of tear production measuring tear meniscus volume [ 31 ]. Although the home environment during quarantine may protect from harm to the ocular surface, tear production may decrease due to parasympathetic nervous system decline [ 34 ], sedentary lifestyles [ 35 ], depression [ 36 , 37 ], anxiety and lack of social support [ 38 ]. Indeed, telework has negative and positive effects on ocular symptoms and signs.…”
Section: Discussionmentioning
confidence: 99%
“…Emotional exhaustion or burnout occurs due to an individual's inability to deal with problems in a social environment such as work, school, or college [14]. During this pandemic, there was a very drastic change in the lecturing environment, where students were required to be able to take lectures online.…”
Section: Risk Factors Of Cvsmentioning
confidence: 99%
“…This makes it difficult for the human eye to focus because the human eyes cannot sustain focus on the pixel characters [13]. Stress, anxiety, depression, and sleep disturbance are also associated with dry eye disease, especially during COVID-19 [14].…”
Section: Introductionmentioning
confidence: 99%