2023
DOI: 10.3389/fnins.2023.1235822
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The association between epilepsy and COVID-19: analysis based on Mendelian randomization and FUMA

Mingyao You,
Ping Yuan,
Liangqian Li
et al.

Abstract: ObjectiveA multitude of observational studies have underscored a substantial comorbidity between COVID-19 and epilepsy. This study was aimed at establishing a conclusive causal link between these two conditions.MethodsWe employed Mendelian randomization (MR) to evaluate the causal link between COVID-19 and epilepsy, as well as its focal and generalized subtypes. The GWAS for epilepsy and its subtypes database were abstracted from both FinnGen consortium and ILAE. Additionally, we leveraged functional mapping a… Show more

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“…We further performed a FUMA analysis according to previous works to better understand the genetic mechanisms underlying the causal relationships between RA and thyroid functions 39,40 . This analysis was performed using summary‐level GWAS data from validated bidirectional causality.…”
Section: Methodsmentioning
confidence: 99%
“…We further performed a FUMA analysis according to previous works to better understand the genetic mechanisms underlying the causal relationships between RA and thyroid functions 39,40 . This analysis was performed using summary‐level GWAS data from validated bidirectional causality.…”
Section: Methodsmentioning
confidence: 99%