The Association between Genetic Variation in Wnt Transcription Factor<i>TCF7L2</i>(<i>TCF4</i>) and Alopecia Areata

Rajabi, Fateme; Amoli, Mahsa M.; Robati, Reza M.; Almasi‐Nasrabadi, Mina; Jabalameli, Navid; Moravvej, Hamideh

doi:10.1080/08820139.2019.1597109

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…On the other hand, some inflammatory markers which have role in metabolic syndrome are IL‐4, IL‐6, IL‐7, IL‐8, IL‐9, IL‐10, G‐CSF, and TNF‐α that are also main mediators in AA 16 . AA and metabolic syndrome may have some similarities in genetic basis 18 …”

Section: Discussionmentioning

confidence: 99%

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Metabolic syndrome in patients with Alopecia Areata: A case‐control study

Abdollahimajd

Niknezhad

Bahreini

et al. 2021

Dermatologic Therapy

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The aim of this study was to evaluate metabolic syndrome prevalence in patients with Alopecia Areata compared to controls. Sixty eligible patients with Alopecia Areata and 60 healthy subjects frequency matched for age and sex attending to our referral dermatology clinics from 2015 to 2017 were enrolled. Prevalence of metabolic syndrome and its components were compared between the two groups. Metabolic syndrome was only seen in seven patients (11.67%) and four controls (6.67%) without a significant difference (P = .34). The clinical presentations of AA included patch type (38.33%), ophiasis (6.67%), alopecia totalis (16.67%), and alopecia universalis (38.33%). Presence of metabolic syndrome was significantly associated with abdominal circumference (OR: 1.10, 95% CI for OR: 1.02to 1.19). Although there was no significant association between Alopecia Areata and metabolic syndrome, some components of metabolic syndrome were more prevalent in these patients. It may be concluded Alopecia Areata patients are at a higher risk of developing metabolic syndrome in the future. Further studies with larger sample sizes are needed.

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Section: Discussionmentioning

confidence: 99%

“…16 AA and metabolic syndrome may have some similarities in genetic basis. 18 Insulin resistance (IR) plays an important role in the pathophysiology of metabolic syndrome. 16 Increased IR has been found in AA.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in patients with Alopecia Areata: A case‐control study

Abdollahimajd

Niknezhad

Bahreini

et al. 2021

Dermatologic Therapy

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“…The importance of WNT10A and the Wnt/β-catenin signaling pathway in hair biology is highlighted by the association between polymorphisms and multiple forms of hair loss. In additional to ectodermal dysplasia WNT10A polymorphisms are associated with the development of androgenetic alopecia and polymorphisms in other genes involved in the Wnt/β-catenin signaling pathway have been directly linked to alopecia areata [19,20]. Further, differential expression of Wnt/β-catenin associated genes has been observed in alopecia areata patients [21].…”

Section: Case Discussionmentioning

confidence: 99%

“…Further, differential expression of Wnt/β-catenin associated genes has been observed in alopecia areata patients [21]. Although autoimmune disease, such as alopecia areata, is primarily mediated by autoimmune dysregulation, alterations in the Wnt/β-catenin signaling have been proposed to contribute to alopecia areata by increasing the proportion of quiescent hair follicles and thus decreasing the threshold for clinically apparent hair loss [20].…”

Section: Case Discussionmentioning

confidence: 99%

Alopecia areata in a patient with WNT10A heterozygous ectodermal dysplasia

Liu¹,

Vandiver²,

Harter³

et al. 2021

DOJ

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“…Similar to the results of previously reported studies, hair loss and the postponement of eye opening in offspring exposed to parental uveitis during gestation were observed on days 14-39 after birth in the present study. The upregulated genes, such as homeobox protein aristaless-like 4 related to hair follicle development (20), follistatin l5 (21), and Wnt transcription factor 4 related to hair follicle differentiation (22,23) in the DEGs may provide the evidence for hair loss in F1 offspring gestated with parental uveitis. In addition, the functions of different gene expression profiles in the eye were also enriched in regard to the muscle system processes related to muscle contraction, muscle structure development, skeletal muscle contraction, and muscle filament sliding.…”

Section: Discussionmentioning

confidence: 99%

Parental Uveitis Influences Offspring With an Increased Susceptibility to the Experimental Autoimmune Uveitis

Yin

Zeng

et al. 2020

Front. Immunol.

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Purpose: Previous studies have shown that parental abnormal physiological conditions such as inflammation, stress, and obesity can be transferred to offspring. The purpose of this study was to investigate the impact of parental uveitis on the development and susceptibility to experimental autoimmune uveitis (EAU) in offspring. Methods: Parental male and female B10RIII mice were immunized with interphotoreceptor retinoid binding protein (IRBP) 161-180 in complete Freund's adjuvant and were immediately allowed to mate. Gross examination of the offspring gestated with EAU was performed to determine the influence of parental uveitis on offspring development after birth. Gene expression profiles were analyzed in the affected eyes of offspring under EAU to identify differentially expressed genes (DEGs). Adult offspring were given 5, 25, and 50 µg IRBP 161−180 to compare their susceptibility to EAU. Immunized mice were clinically and pathologically evaluated for the development of EAU. Ag-specific T-cell proliferation and IL-17 production from spleens and lymph nodes were evaluated on day 14 or 35 after immunization. Results: Hair loss, delay of eye opening, and swollen spleens in the offspring from parents with uveitis were observed from day 14 to 39 after birth. DEGs were involved in the immune system process, muscle system process, and cell development. The altered antigen processing and presentation, cell adhesion molecules, and phagosome in the eyes of the offspring from uveitis-affected parents were enriched. Offspring gestated with EAU showed a susceptibility to EAU and an earlier onset and higher severity of EAU compared to the control group mice. IRBP-specific lymphocyte proliferation and IL-17 production were observed in the EAU offspring with exposure to parental uveitis. Conclusions: The results suggest that mouse parents with uveitis can increase their offspring's susceptibility to EAU, probably through altering cell adhesion molecules and antigen processing and presentation related to the T-cell proliferation and Th17 response.

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The Association between Genetic Variation in Wnt Transcription FactorTCF7L2(TCF4) and Alopecia Areata

Cited by 11 publications

References 38 publications

Metabolic syndrome in patients with Alopecia Areata: A case‐control study

Metabolic syndrome in patients with Alopecia Areata: A case‐control study

Alopecia areata in a patient with WNT10A heterozygous ectodermal dysplasia

Parental Uveitis Influences Offspring With an Increased Susceptibility to the Experimental Autoimmune Uveitis

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