ABSTRACT. Objective: The purpose of this study was to examine the cross-sectional and longitudinal associations among alcohol use disorder (AUD), stressful life events, and marital dissolution in a probability sample of adults. Method: The National Epidemiologic Survey on Alcohol and Related Conditions is a prospective, longitudinal study of a probability sample of 43,083 adults 18 years of age and older living in the United States. The interval between Wave 1 (W1) and Wave 2 (W2) was approximately 3 years. Cross-sectional analyses included 32,359 adults ages 18 and older who were ever married at W1, and longitudinal analyses included 17,192 adults who were currently married at W1 and who completed relevant W2 measures. Participants completed inhome surveys conducted with computer-assisted personal interviewing. Results: Rates of lifetime marital dissolution were signifi cantly higher among those with lifetime AUD (48.3%) than in those with no lifetime AUD (30.1%). The incidence of marital dissolution from W1 to W2 was 15.5% for those with a past-12-month AUD at W1, compared to 4.8% among those with no AUD. Proportional hazards regression analyses showed that past-12-month AUD, tobacco use disorder, other substance use disorder, stressful life events, older age at marriage, being married more than once, and being married to an alcoholic at W1 predicted greater hazards of marital dissolution at W2. These associations were not moderated by gender. Conclusions: AUD and stressful life events predict subsequent marital dissolution independently of other substance use disorders, mood and anxiety disorders, and personality disorders. Results were discussed within the framework of the Vulnerability-Stress-Adaptation model of marriage. (J. Stud. Alcohol Drugs, 75, 520-529, 2014) Leonard and Rothbard (1999) noted that "perhaps because of the commonsense appeal that drinking causes marital problems and divorce, few studies have systematically addressed this issue" (p. 143). Although several studies have established linkages between AUD and indicators of marital quality (e.g., Cranford et al., 2011;Whisman, 2007;Whisman et al., 2006), few longitudinal studies have tested the hypothesis that AUD leads to marital dissolution (Chilcoat and Breslau, 1996;Smith et al., 2012b). High rates of comorbidity between AUD and other psychiatric disorders make it diffi cult to determine the relative importance of AUD as a predictor of marital dissolution. In addition, research examining gender differences in the association between AUD and marital outcomes has yielded confl icting evidence. The present study addressed these limitations by (a) testing the hypothesis that AUD predicts marital dissolution using longitudinal data from a national probability sample, (b) simultaneously assessing the effects of other psychiatric disorders, and (c) examining gender as a possible moderator of these associations.Research documenting the association between alcohol involvement and marital status has a long history, going back more than 100 yea...