The Association Between Helicobacter Pylori and Perforated Gastroduodenal Ulcer

Abstract

Background Although the role of Helicobacter pylori (H. pylori) is well known in peptic ulcer disease (PUD) etiology, its role in perforated peptic ulcer (PPU) is not well established. This study aimed to assess the role of H. pylori infection in patients with PPU and to compare it with its prevalence in patients with PUD. Methodology This prospective analytical study was conducted for two years. The study patients were classified into two groups: group I consisted of patients (n = 48) operated for PPU and group II were patients (n = 48) with PUD diagnosed by endoscopy. The study excluded patients with any previous anti-H. pylori treatment, gastric malignancy, conservative management of sealed PPU, and those with a diameter of perforation less than the diameter of endoscopic biopsy forceps. Blood samples were taken for H. pylori serology IgG (ELISA) test. The mucosal biopsy samples from both the groups were tested with a rapid urease test and modified Giemsa stain examination to detect H. pylori.

The Prevalence, Etiology and Treatment of Gastroduodenal Ulcers and Perforation: A Systematic Review

“…Studies by Pescatore et al [7] and Tokunaga et al [8] showed the highest H. pylori prevalence among patients with GDP and ranged from 92% to 100% (n = 119 patients), compared to the other studies that showed a prevalence of infection between 20 and 84.6% (n = 1457) [9][10][11][12][13][14][15][16]. Two of the studies reported the lowest prevalence of H. pylori infection, with 12.5% among a total number of 48 patients and 13.8% among 29 patients with a perforated peptic ulcer, which could be due to the small sample size of both studies [3,17]. 2020) [3] The association between H. pylori and a perforated gastroduodenal ulcer.…”

“…Two of the studies reported the lowest prevalence of H. pylori infection, with 12.5% among a total number of 48 patients and 13.8% among 29 patients with a perforated peptic ulcer, which could be due to the small sample size of both studies [3,17]. 2020) [3] The association between H. pylori and a perforated gastroduodenal ulcer. 48 12.5% (6) Ha et al ( 2016) [11] The gastrointestinal safety of herbal medicine in patients with osteoarthritis.…”

“…Risk factors of gastroduodenal perforation (GDP) vary based on the geographical area associated with sociodemographic and environmental factors, such as overcrowding and poor hygiene in developing countries, and it mostly occurs spontaneously due to peptic ulcer disease [2]. The mean prevalence of H. pylori infection in patients with perforated peptic ulcers is roughly around 65-70%, and this might indicate that there are more factors involved in its pathology [3]. In many countries, the incidence of H. pylori infection has been decreasing in association with an improved standard of living [4].…”

A Comparative Study between Open and Laparoscopic Omental Patch Repair of Perforated Duodenal Ulcer

“…In the present study, 20% of the patients diagnosed with perforated duodenal ulcer mentioned a positive history of NSAIDS intake. Some authors reported a strong evidence of association between NSAIDS intake and duodenal ulcer disease [12,13,14] . It was elucidated that NSAIDs act by inhibiting the COX-II enzyme and thus limiting its gastro-protective effect [15] .…”

Sudden death related to the gastrointestinal system in Tunisia: A 13 year autopsy study

“…According to a recently published study [15], cigarette smoking was found to increase the risk of infection by Helicobacter pylori, a bacterium known for its major role in ulcerogenesis (70%-80% of ulcers are caused by H. pylori) [16,17]. Indeed, smoking significantly promotes the development and permanence of the ulcer by increasing acid secretion through the increase of the gastric parietal cell mass, by decreasing the secretion of bicarbonate and endogenous prostaglandins, and delaying the ulcer's healing [18][19][20][21].…”