The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample

Tsujita, Yasuyuki; Nakamura, Yasuyuki; Qishan, Zhang; Tamaki, Shinji; Nozaki, Akihiko; Amamoto, Kenji; Kadowaki, Takashi; Kita, Yoshikuni; Okamura, Tomonori; Horie, Minoru; Ueshima, Hirotsugu

doi:10.1016/j.atherosclerosis.2006.03.028

Cited by 30 publications

(27 citation statements)

References 28 publications

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“…It is currently believed that CHD is caused by multiple genetic factors combined with environmental factors (Tsujita et al, 2007;Kimura, 2009), and that lipid metabolism disorder can lead to the occurrence of CHD (Kolovou et al, 2011). The present study demonstrated that the plasma levels of TC, LDL-C, and lipoprotein(a) were significantly higher in the ACS and stable CHD groups compared to the control group.…”

Section: Discussionsupporting

confidence: 53%

“…Dyslipidemia is a recognized important risk factor for CHD. Previous studies (Hsieh et al, 2007;Tsujita et al, 2007;Kimura, 2009;Estévez-González et al, 2010) have demonstrated that the cholesterol ester transfer protein (CETP) plays a vital role in lipid metabolism. Expression of the CETP gene determines its function, thereby affecting lipid metabolism and CHD occurrence and development.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

Zhang

Xie

et al. 2014

Genet. Mol. Res.

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ABSTRACT. This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (ACS) group, and a stable coronary heart disease (CHD) group. Blood biochemical indices were determined using the enzyme method, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to study the TaqIB polymorphism of the CETP gene. The ACS and stable CHD groups were treated with atorvastatin, and blood lipid levels were reexamined after three months. Plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a) were all significantly higher in the ACS 2141 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 2140-2148 (2014) Coronary atherosclerotic heart disease and stable CHD groups compared to the control group (P < 0.05 or P < 0.01). After three months of treatment with atorvastatin, plasma levels of TC, LDL-C, triglycerides (TG) (only in patients with genotype B2B2), and lipoprotein(a) (only in patients with genotype B1B2) were all significantly decreased (P < 0.05 or P < 0.01). After treatment, the plasma level of TG was lower in patients with genotype B2B2 compared to patients with genotypes B1B1 or B1B2 (B1 carriers) (P < 0.01). Therefore, the CETP TaqIB polymorphism is associated with the lipid-lowering effect of atorvastatin in patients with CHD.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

Zhang

Xie

et al. 2014

Genet. Mol. Res.

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“…A classic example is the study of Fumeron et al ( 17 ) in French males in which a gene-alcohol interaction was described where the effect of B2 on HDL-C concentrations was absent in subjects drinking <25 g/d of alcohol but increased at higher levels. Following this observation, many studies have been published with inconsistent results ( 9,(18)(19)(20)(21)(22)38 ). In a prior study ( 20 ), we found no signifi cant TaqIBalcohol interaction in determining HDL-C in a healthy Mediterranean population.…”

Section: Discussionsupporting

confidence: 49%

“…Regarding prior studies that have analyzed gene-environmental interactions, a lack of consistency is observed. Some studies have reported that alcohol consumption statistically interacts with the TaqIB SNP and modifi es its effects on HDL-C concentrations (17)(18)(19), whereas others have not supported this interaction (20)(21)(22). Likewise, although there is one observational study ( 23 ) in which a statistically signifi cant interaction between the TaqIB-SNP and fat intake was found, those results have not been replicated ( 24 ).…”

Section: Demographic Clinical Anthropometric and Dietary Measurementsmentioning

confidence: 99%

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population

Corella

Carrasco

Fitó

et al. 2010

Journal of Lipid Research

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We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the ؊ 4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D´= 0.88; P < 0.001). They were independently associated with higher HDL-C ( P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically signifi cant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were

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“…Two previous meta-analyses have documented that CETP genetic variants related to moderate inhibition of CETP activity were associated with favorable blood lipid levels and decreased cardiovascular risk ( 10,11 ). Several observational studies reported that CETP variants might interact with dietary factors, especially dietary fat intake, on HDL cholesterol levels (12)(13)(14)(15), although the fi ndings were not consistently replicated ( 11,(16)(17)(18)(19)(20). In addition, two small short-term diet intervention studies did not demonstrate the interaction between CETP genotype and dietary fat intake ( 21,22 ).…”

Section: Discussionmentioning

confidence: 99%

CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials

Durst

Schwarzfuchs³

et al. 2015

Journal of Lipid Research

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Unfavorable blood lipid levels, such as elevated levels of total cholesterol, LDL cholesterol, and triglycerides, and reduced levels of HDL cholesterol, have been associated with increased risk of CVDs ( 1-3 ). Lipid levels are determined by genetic and environmental factors, as well as their interactions ( 4, 5 ). There has been great interest in investigating cholesteryl ester transfer protein (CETP), a plasma glycoprotein that facilitates the transfer of cholesteryl ester and triglycerides between HDL and other lipoproteins ( 6 ), in relation to blood lipids. CETP defi ciency due to CETP gene mutation causes increased HDL cholesterol levels ( 7,8 ). In patients with low Abstract Little is known about whether cholesteryl ester transfer protein ( CETP ) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)], and replicated the fi ndings in 171 overweight/obese adults from an independent 2 year weight-loss trial [Dietary Intervention Randomized Controlled Trial (DIRECT)]. In the POUNDS LOST, participants with the CETP rs3764261 CC genotype on the high-fat diet had larger increases in HDL cholesterol ( P = 0.001) and decreases in triglycerides ( P = 0.007) than those on the low-fat diet at 6 months, while no signifi cant difference between these two diets was observed among participants carrying other genotypes. The gene-diet interactions on changes in HDL-cholesterol and tri glyc erides were replicated in the DIRECT (pooled P for interaction ≤ 0.01). Similar results on trajectory of changes in HDL cholesterol and triglycerides over the 2 year intervention were observed in both trials. Our study provides replicable evidence that individuals with the CETP rs3764261 CC genotype might derive greater effects on raising HDL cholesterol and lowering triglycerides by choosing a low-carbohydrate/high-fat weight-loss diet instead of a low-fat diet. -Qi, Q

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The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample

Cited by 30 publications

References 28 publications

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population

CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials

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