The Association between HLA Antigens and Inflammatory Bowel Disease in Iraqi Patients

Ad’hiah, Ali H.; Jasim, Hamsa Ahmed; Fadhil, Ayad M. A.

doi:10.22401/jnus.9.1.10

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“…Two clinical forms of the disease exist-ulcerative colitis and Crohn's disease-which have a number of different clinical and pathological features.HLA-A9, B41 and DR8 showed an association with this disease [28]. There is a strong association between IBD and HLA-G [29].…”

Section: Inflammatory Bowel Disease(ibd)mentioning

confidence: 99%

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Relationship between HLA Typing and Different Diseases in IRAQ

Mahdi¹

2013

Clon Transgen

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Human leukocyte antigen system is the major histocompatibility complex in humans, which includes several hundreds of genes located in a highly polymorphic region of chromosome 6 that encode for proteins critical for the immune system. HLA Class I antigens (A, B and C) transport and present peptides produced by degradation of proteins inside the cell like viral antigens, to CD8+ T cells, in addition to that the HLA Class I, carry also foreign or not-self antigens. Under normal conditions, these T -cell CD 8+ cells recognize but do not destroy those cells with the right "self"Ag, unless they also carry a non-self antigen. Under pathological conditions, like in certain autoimmune diseases T cells can destroy cells carrying self-antigens, causing autoimmune diseases. The role of HLA Class II antigens (DRB1, DRB3,4,5, DQA1/DQB1, DPB1) is to present the peptides from processed proteins that are produced outside the cell, derived from bacteria and protozoa, to helper T-cells CD4+ to stimulate their multiplication. These helper T cells then stimulate B-cells to produce antibodies against the foreign antigens. HLA and disease associations have been widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance or protective and of evolutionary maintenance of genetic diversity. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, and other diseases with unknown etiology in Iraq and attempt to summarize some remarkable HLA alleles related with specific diseases.

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Section: Inflammatory Bowel Disease(ibd)mentioning

confidence: 99%

“…The expression of non-classic HLA Class I (HLA-G) is under epigenetic control, i.e. when the DNA is methylated the expression of HLA-G is suppressed [28]. There is evidence that HLA-G produce by many types of cancer cells.…”

Section: Inflammatory Bowel Disease(ibd)mentioning

confidence: 99%

Relationship between HLA Typing and Different Diseases in IRAQ

Mahdi¹

2013

Clon Transgen

View full text Add to dashboard Cite

show abstract

The Association between HLA Antigens and Inflammatory Bowel Disease in Iraqi Patients

Cited by 1 publication

References 0 publications

Relationship between HLA Typing and Different Diseases in IRAQ

Relationship between HLA Typing and Different Diseases in IRAQ

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