The association between HSD17B1 Ser312Gly polymorphism and breast cancer risk: a meta-analysis including 31,053 subjects

Yao, Lei; Cao, Lanqing; Qiu, Lixin; Liu, Yu

doi:10.1007/s10549-010-0784-4

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…In America, higher E2 levels were observed among postmenopausal lean women with the AA (or TT) genotype, whereas no overall effect of the genotype was reported on breast cancer risk ( 49 ) . Furthermore, two meta-analyses of multiethnic subjects showed no association of rs605059 with breast cancer risk ( 14 , 50 ) . To our knowledge, we are the first to explore the interaction between macronutrient intake and the HSD17B1 rs605059 polymorphism with serum sex hormone concentrations.…”

Section: Discussionmentioning

confidence: 99%

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women

et al. 2017

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Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 % CI 1·04, 1·28) and 1·15 (95 % CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 % CI 0·82, 0·99), 0·89 (95 % CI 0·81, 0·98) and 0·91 (95 % CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women

et al. 2017

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“…Potentially functional polymorphisms in the estrogen-metabolizing genes may influence their biological function, and thereby influence the susceptibility to hormone-related cancer (Abbas et al, 2010; Tsuchiya et al, 2005). A meta-analysis including 13,987 cases and 17,066 controls was carried out in 2010 to estimate the relationship between HSD17B1 Ser312Gly and risk of breast cancer, and no significant association was observed (Yao et al, 2010). With the inclusion of more investigations, our meta-analysis replicated this previously reported null association.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of HSD17B1 Ser312Gly with Cancer Risk: Evidence from 66,147 Subjects

et al. 2016

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Hydroxysteroid (17-beta)dehydrogenase 1(HSD17B1) plays a central role in sex steroid hormone metabolism. HSD17B1 polymorphic variants may contribute to cancer susceptibility. Numerous investigations have been conducted to assess the association between HSD17B1 Ser312Gly polymorphism and cancer risk in multiple ethnicities, yet these have produced inconsistent results. We therefore performed this comprehensive meta-analysis to attempt to provide a quality assessment of the association of interest. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. After a systematic literature search of several major public databases, 20 studies involving 29,460 cases and 36,687 controls were included in this meta-analysis. No significant association was found between HSD17B1 Ser312Gly polymorphism and cancer risk. However, Ser312Gly polymorphism showed a significantly decreased risk for Caucasians (there were 44,284 Caucasians for analysis, comprising 19,889 cases and 24,395 controls) in the subgroup analysis by ethnicity (dominant: OR = 0.958, 95% CI = 0.919-0.998; and allele comparing: OR = 0.973, 95% CI = 0.947-0.999). And there was the same trend towards risk in the population-based (PB) controls (homozygous: OR = 0.951, 95% CI = 0.908-0.997 and allele comparing: OR = 0.976, 95% CI = 0.954-0.999), but not among Asians or hospital-based (HB) controls. In addition, no association was observed in the stratified analysis for breast cancer studies by source of control, ethnicity and quality score. These findings suggested that the HSD17B1 Ser312Gly polymorphism might confer genetic cancer susceptibility in an ethnic-dependent manner, especially among Caucasians. Well-designed, large-scale studies are warranted to validate these findings.

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“…Polymorphism of the HSD17β1 gene (rs605059) has been reported to play an important role in the development of estrogen-dependent diseases such as uterine leiomyomas, colorectal cancer and breast cancer (23-27).…”

Section: Discussionmentioning

confidence: 99%

“…The allele frequency of the polymorphism of gene HSD17β1 varies according to the ethnic group or geographic location of the population under study (27). In the present study, the allele frequency for the control group was 44% for allele A and 56% for allele G, this being the first Brazilian study to report the frequencies of these alleles in the population.…”

Section: Discussionmentioning

confidence: 99%

Ser312Gly Polymorphism of the HSD17β1 Gene is not Associated with Endometriosis in Brazilian Patients

Santos

Oliveira

Falagan-Lotsch

et al. 2014

Journal of Endometriosis and Pelvic Pain Disorders

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Purpose The aim of this study was to determine whether a polymorphism of the HSD17β1 gene (rs605059), involved in estrogen synthesis, is associated with endometriosis in Brazilian patients. Methods A case-control study was conducted in 231 women. All patients in the case group had a histopathological diagnosis of endometriosis. Genomic DNA was genotyped by nested-PCR, followed by digestion of the PCR product with the enzyme BstUI. Results The frequencies of the genotypes detected in the case and control groups were 22.4% GG, 52.2% AG and 25.4% AA; and 31.3% GG, 49.3% AG and 19.4% AA, respectively, with no significant difference between groups. The prevalence of the G allele was 48.5% and 56% in the case and control groups, respectively. No significant difference in genotype or allele frequency was detected between the different stages of endometriosis (p>0.05). Conclusions The results suggested that the Ser312Gly polymorphism of the HSD17β1 gene is not associated with endometriosis in Brazilian patients.

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The association between HSD17B1 Ser312Gly polymorphism and breast cancer risk: a meta-analysis including 31,053 subjects

Cited by 9 publications

References 19 publications

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women

Polymorphism of HSD17B1 Ser312Gly with Cancer Risk: Evidence from 66,147 Subjects

Ser312Gly Polymorphism of the HSD17β1 Gene is not Associated with Endometriosis in Brazilian Patients

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