The Association Between Hyperparathyroidism and Ischemic Stroke Subtypes

Abstract

Background: Up to date, a substantial amount of research has remarked on the potential role of parathormone (PTH) in the development of subclinical and clinical vascular diseases. However, the association between the hyperparathyroidism and cerebrovascular disease has rather been underestimated in the literature. Herein, we aimed to investigate the association between serum PTH levels and ischemic stroke.Methods: Serum PTH levels were measured in all patients with ischemic stroke who were hospitalized in the Yozgat City Hospital between January 1, 2017 and January 1, 2019. Clinical and demographic findings were retrospectively evaluated via computer-based patient record system of Yozgat City Hospital (AKGUN). Results:Overall, 158 patients with ischemic stroke with a median age of 71.5 ± 11.5 were enrolled in this study. Parathyroid hormone was found to be high in 31 of the patients (19.6%). The stroke subtype of extracranial atherosclerosis was found to be more common in the group of patients with a high level of PTH (12%/3%; P = 0.008). Remarkably, logistic regression analyses also confirmed that high PTH level was a significant variable in the determination of the stroke subtype of extracranial atherosclerosis (P = 0.024). Conclusions:We have found a high rate of hyperparathyroidism in our group of patients with ischemic stroke. Remarkably, the elevation of PTH was found to be significantly associated with the ischemic stroke subtype of extracranial atherosclerosis. Clarification of these results in the future large-scale studies may provide crucial perspectives regarding our understanding of the pathophysiology of some subtypes of ischemic stroke and potentially lead to a large public health implication in this area.

Silent neurological lesions detected by magnetic resonance imaging: Relationship to hyperparathyroidism among end‐stage renal disease young patients on haemodialysis

“…Several studies were focussing on the association between PTH and stroke and clarified a significant correlation between HPT and ischaemic stroke. However, these studies were done among nonrenal failure patients [39][40][41] Our study revealed that; SBL in conventional MRI imaging were highly positive correlated with serum calcium (cut off point ˃7.5 mg/ dL), duration of haemodialysis (cut off point ˃2 years) and PTH (cut off point ˃585 pg/mL) on ROC curve analysis and multivariate analysis. Therefore, PTH and the duration of dialysis may be considered as independent predictor factors for the presence of SNL and strongly correlated to it, which may be because of combined cerebral small A recent study by Honglan et al showed that ESRD patients who had HPT were associated with cognitive and cerebral dysfunction 42 and a study in Japan done by Tagawa et al found that haemorrhagic stroke was associated with PTH level >500 pg/mL, and ischaemic stroke was not related to PTH level.…”

Stroke and kidney transplantation

“…Onder and Arslan [30] studied 158 patients with ischemic stroke and found that 31 of the patients (19.6%) had high serum parathyroid hormone levels. In a 1972 study, Boström et al investigated the incidence of stroke in hyperparathyroid patients ( n = 170), which was found to be 7.1% [69].…”