The association between hyperuricemia and betel nut chewing in Taiwanese men: a cross-sectional study

Abstract

BackgroundStudies have associated betel nut chewing with cancers, metabolic syndrome, cardiovascular disorders, chronic kidney disease, and proteinuria. This study investigated whether hyperuricemia is associated with betel nut chewing in men who participated in a health check-up program.MethodsFrom hospital records, we identified a total of 11,991 men who participated in the health check-up program from 2003 to 2009. They were divided into hyperuricemic group and non-hyperuricemic group. Laboratory tests, medical history, and status of cigarette smoking, alcohol consumption, and betel nut chewing were compared between the 2 groups. We calculated odds ratio (OR) and 95% confidence interval (CI) of hyperuricemia in association with betel nut consumption and other factors.ResultsCompared with the non-hyperuricemic group, the hyperuricemic group was slightly older (59.4 vs. 58.6 years) but less prevalent with betel nut use (11.8 vs. 13.6%, p = 0.003). Multivariable logistic regression analysis showed that hyperuricemia was negatively associated with betel nut chewing (OR 0.75, 95% CI 0.66-0.84), older age (OR 0.84, 95% CI 0.77-0.93), and diabetes mellitus (OR 0.57, 95% CI 0.50-0.64). On the other hand, hyperuricemia was positively associated with body mass index (OR 1.75, 95% CI 1.62-1.90), drinking (OR 1.36, 95% CI 1.25-1.49), hypertension (OR 1.41, 95% CI 1.30-1.52), mixed hyperlipidemia (OR 1.84, 95% CI 1.33-2.54), chronic kidney disease (OR 3.28, 95% CI 2.94-3.65), and proteinuria (OR 1.22, 95% CI 1.08-1.38). Smoking, hypercholesterolemia, and hypertriglyceridemia had no significant association with hyperuricemia.ConclusionOur data suggest that betel nut chewing is negatively associated with hyperuricemia.

Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride

“…Because the β cell function declines with diabetic duration, patients with newly diagnosed drug naive T2DM would be suitable subjects of T2DM study. Hyperlipidemia, an increase of total cholesterol (TC) and/or triglycerides (TGs) in the serum, is one of the most common T2DM related comorbidities [ 6 ]. Diabetic dyslipidemia is characterized by moderately increased TG levels and reduced high density lipoprotein-cholesterol (HDL-C), which is a well-recognized causes for atherosclerotic cardiovascular diseases [ 7 , 8 ].…”

ImpairedβCell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia

“…The prevalence of T2DM and prediabetes in China was 9.7% and 15.5%, respectively, which implies that there were 92.4 million adults with diabetes and 148.2 million adults with prediabetes [ 1 ]. Hyperlipidemia, one of the most common T2DM related comorbidities, refers to the increase of total cholesterol or/and triglycerides in the serum [ 2 ]. On the one hand, insulin resistance diverts carbohydrate away from muscle glycogen storage into hepatic de novo lipogenesis, thus leading to the increase of plasma triglyceride concentration [ 3 ].…”

Associations of cigarette smoking, betel quid chewing and alcohol consumption with high-sensitivity C-reactive protein in early radiographic knee osteoarthritis: a cross-sectional study

“…As far as we know, very few studies have investigated the relationship between betel quid chewing and OA, although betel quid chewing is associated with some well-known disorders. 12 49–51 In vivo data revealed that betel quid extract could intensify the inflammatory response as well as the expression of tumour necrosis factor-α in mice models. 52 Tsai et al 29 indicated that betel quid chewing was not significantly associated with CRP concentration, which agrees with our findings.…”