The Association Between <i>hMLH1</i> and <i>hMSH2</i> Polymorphisms and Renal Tumors in Northeastern China

Xing, Zhaohui; Guo, Genmao; Pan, Xiaoyun; Xu, Lei; Guo, Chaopu; An, Ruihua

doi:10.1089/gtmb.2019.0011

Cited by 1 publication

(1 citation statement)

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“…The results revealed that decrease in DNMT1 and histone deacetylase activities, that probably block epigenetically mediated gene silencing, might provide an emerging clinical strategy to help prevent lung cancer. In addition, compelling evidence suggests that human MutL Homolog 1 (hMLH1) and human MutS Homolog 2 (hMSH2) are closely associated with the development and drug resistance of cancer ( Xing et al, 2019 ). Based on the previous study, Wu et al (2020) found that DNMT1 could suppress the expressions of hMLH1 and hMSH2 via promoting their promoter methylation, thus promoting cell proliferation in epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC).…”

Section: The Functional Role Of Various Types Dnmts In Cancermentioning

confidence: 99%

Emerging role of different DNA methyltransferases in the pathogenesis of cancer

et al. 2022

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DNA methylation is one of the most essential epigenetic mechanisms to regulate gene expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the genome. In mammals, DNMTs act with some elements to regulate the dynamic DNA methylation patterns of embryonic and adult cells. Conversely, the aberrant function of DNMTs is frequently the hallmark in judging cancer, including total hypomethylation and partial hypermethylation of tumor suppressor genes (TSGs), which improve the malignancy of tumors, aggravate the ailment for patients, and significantly exacerbate the difficulty of cancer therapy. Since DNA methylation is reversible, currently, DNMTs are viewed as an important epigenetic target for drug development. However, the impression of DNMTs on cancers is still controversial, and therapeutic methods targeting DNMTs remain under exploration. This review mainly summarizes the relationship between the main DNMTs and cancers as well as regulatory mechanisms and clinical applications of DNMTs in cancer and highlights several forthcoming strategies for targeting DNMTs.

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Section: The Functional Role Of Various Types Dnmts In Cancermentioning

confidence: 99%